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Comparative nucleotide sequence analysis of the phosphoprotein gene of peste des petits ruminants vaccine virus of Indian origin 总被引:2,自引:0,他引:2
Muthuchelvan D Sanyal A Sarkar J Sreenivasa BP Bandyopadhyay SK 《Research in veterinary science》2006,81(1):158-164
The nucleotide sequences of the phosphoprotein (P) gene of peste des petits ruminants (PPRV) vaccine virus (PPRV Sungri/96) belongs to Asian lineage have been determined and the deduced amino acid sequences were compared with another vaccine strain PPRV/Nigeria75/1 and with those of the other morbilliviruses. The 1652 nucleotides of the P gene encode a phosphoprotein of 509 amino acid residues (from nucleotide numbers 60 to 1587), which is 91% identical to that of PPRV/Nigeria75/1. The C protein consists of 177 amino acid residues and is 91% identical with that of PPRV/Nigeria75/1. The conserved mRNA editing site (5'TTAAAAGGGCACAG) was present at positions 742-756 in the P gene, which is conserved in all other morbilliviruses. The CTT trinucleotide sequence is present at the N/P and P/M intergenic region, which is totally conserved in morbilliviruses. This will be the third sequence for the P gene of PPRV since that of the vaccine strain and a wild-type Turkish isolate has been published already. 相似文献
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Analysis of the matrix protein gene sequence of the Asian lineage of peste-des-petits ruminants vaccine virus 总被引:4,自引:0,他引:4
Muthuchelvan D Sanyal A Sreenivasa BP Saravanan P Dhar P Singh RP Singh RK Bandyopadhyay SK 《Veterinary microbiology》2006,113(1-2):83-87
The M gene nucleotide sequence of an Indian peste-des-petits ruminants (PPRV) vaccine virus ("PPRV Sungri/96") belonging to Asian lineage was determined. The gene is 1476 nucleotides long with a single open reading frame (ORF). The nucleotide and predicted amino acid sequence was compared with the homologous region of the African Lineage Vaccine virus "PPRV/Nigeria/75/1". The nucleotide sequence of the "PPRV Sungri/96" was 86% identical to that of "PPRV/Nigeria/75/1", while a homology of 93% and 95% could be observed in the ORF and amino acids level, respectively. The M gene encodes a protein of 335 amino acids, with a predicted molecular weight (MW) of 37.8 kDa. The ORF is flanked by a 3' untranslated region of 436 nucleotides and a high level of sequence divergence (approximately 30%) could be observed in this region between the vaccine viruses of Asian and African lineages. A high degree of conservation of several amino acids of this protein observed previously was also confirmed in this study. 相似文献
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Sequence Analysis of the Nucleoprotein Gene of Asian Lineage Peste des Petits Ruminants Vaccine Virus 总被引:3,自引:0,他引:3
Muthuchelvan D Sanyal A Balamurugan V Dhar P Bandyopadhyay SK 《Veterinary research communications》2006,30(8):957-963
The complete nucleotide sequence of the nucleocapsid (N) protein of the peste-des-petits ruminants vaccine virus (PPRV Sungri/96)
belonging to the Asian lineage was determined. The gene was 1692 nucleotides in length and encoded a polypeptide of 525 amino
acids. The PPRV Sungri/96 N gene has a nucleotide homology of 92% for PPRV Nigeria 75/1 to 55.5% for canine distemper virus.
At amino acid level the homology was 94.1% with PPRV Nigeria 75/1, while with other morbilliviruses, PPRV Sungri/96 had only
71.4–64.9% amino acid identity. The phosphorylation prediction reveals eight conserved sites across morbilliviruses, whereas
in the C-terminal portion of the protein the sites are not conserved. Phylogenetic analysis of different N proteins of morbilliviruses
revealed five well-defined clusters as observed previously. To the best of our knowledge this is the first report describing
the nucleocapsid gene sequence of PPRV Indian isolate.
Muthuchelvan, D., Sanyal, A., Balamurugan,V., Dhar, P. and Bandyopadhyay, S.K., 2006. Sequence analysis of the nucleoprotein
gene of Asian lineage peste des petits ruminants vaccine virus.Veterinary Research Communications, 30(8), 957–963 相似文献
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De Ankan Das Tapan Kumar Chand Karam Debnath Bikas Chandra Dey Saikat Hemadri Divakar Barman Nagendra Nath Chaudhary Jitendra Kumar Muthuchelvan Dhanavelu Saxena Arpit Tewari Neha Chauhan Ankita Lohumi Ankita Biswas Sanchay Kumar 《Tropical animal health and production》2019,51(1):261-265
Tropical Animal Health and Production - Bluetongue (BT) is a notifiable multiple species transboundary viral disease of domestic and wild ruminants. Though the disease is enzootic in India, little... 相似文献
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