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Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA 总被引:1,自引:0,他引:1
Maeda M Lu S Shaulsky G Miyazaki Y Kuwayama H Tanaka Y Kuspa A Loomis WF 《Science (New York, N.Y.)》2004,304(5672):875-878
Self-regulating systems often use robust oscillatory circuits. One such system controls the chemotactic signaling mechanism of Dictyostelium, where pulses of adenosine 3',5'-monophosphate (cAMP) are generated with a periodicity of 7 minutes. We have observed spontaneous oscillations in activation of the mitogen-activated protein (MAP) kinase ERK2 that occur in phase with peaks of cAMP, and we show that ERK2 modulates cAMP levels through the phosphodiesterase RegA. Computer modeling and simulations of the underlying circuit faithfully account for the ability of the cells to spontaneously generate periodic pulses during specific stages of development. Similar oscillatory processes may occur in cells of many different species. 相似文献
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Yuichiro Hiraoka Noritsugu Kuramoto Mineko Ohira Masanori Okamura Toru Taniguchi Yoshitake Fujisawa 《Journal of Forest Research》2011,16(6):509-517
Rhus succedanea L. is cultivated in Japan for the wax that can be extracted from its fruits. We determined genetic data for specific traits
associated with wax production (fruit number per cluster, FN, fruit weight, FW, number of clusters per area, CN, and wax content,
WC) in five traditional cultivars and 13 newer clones. Data were collected over 4 years and alternate bearing was observed:
2001 and 2003 were years with high yields; in 2002 and 2004 yields were poor. The restricted maximum likelihood method was
used to calculate (co)variance components for analysis. Broad sense heritability was estimated and ranged from low (FN and
CN) to high (FW and WC) for the traits examined. There were positive genetic correlations between FW and WC and negative ones
between FN and FW throughout the 4 years. Genetic correlations between CN and the other traits were positive in good crop
years and negative in bad crop years. For each assessed clone, the four traits in the 4 years were evaluated using best linear
unbiased predictors (BLUP) of the clonal breeding values. The BLUP scores for both FW and WC exhibited positive correlations
between pairs of years, whereas there were positive BLUP correlations for CN when the high yield and low yield years were
examined separately. The traditional cultivars and the newer clones were also characterized. Some of the clones were better
than the traditional cultivars with regard to wax yield and reliability of production. The trait characteristics and the future
breeding are discussed. 相似文献
3.
Gyo-Moon CHU Motoharu KOMORI Akira NAKAYAMA Mineko ASANAGI Hideo YANO Tohru MATSUI 《Animal Science Journal》2008,79(4):466-471
We investigated the efficacy of genetically modified yeast (GMY) phytase on phosphorus (P) bioavailability in growing pigs fed a corn–soybean meal based diet. Crossbred barrows were fed a P-adequate, a low-P or a P-deficient diet containing 0.37, 0.27 and 0.14% non-phytate-P, respectively. The P-deficient diet was supplemented with wild-type yeast (WTY), Aspergillus (ASP) or GMY phytase at 750 PU per kilogram of food. Dietary ASP and GMY phytases increased plasma inorganic P (Pi ) concentration and the apparent absorption of P, and decreased the concentration of a bone resorption marker, plasma type-I collagen C-terminal telopeptide (ICTP). Wild-type yeast phytase also increased the apparent absorption of P, but the changes in plasma Pi and ICTP concentrations were not significant. Although the dietary Pi -equivalencies based on plasma Pi and ICTP concentrations did not differ between WTY and ASP phytases, the equivalency of ASP phytase based on apparent absorption of P was higher than that of WTY phytase. The equivalency of GMY phytase calculated from each parameter was higher than that of WTY phytase, and did not differ from that of ASP phytase. These results suggest that efficacy of GMY phytase on P bioavailability was higher than WTY phytase, and as effective as ASP phytase in growing pigs. 相似文献
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Nitrogen is an essential element for living organisms because it is a crucial constituent of biomolecules. Inadequate supply of usable nitrogen reduces plant growth and crop yield. The primary nitrogen sources for plants are nitrate and ammonium in soils, and plants have multiple layers of sensing and adaptive mechanisms that respond to the availability of these nutrients. The adaptive responses are called ‘nitrogen responses,’ which include morphological and physiological responses enabling plants to efficiently take up nitrogen and adapt to spatiotemporal fluctuations in nitrogen abundance in the field. In this review, we summarize the strategies that plants use to respond to changes in the nitrogen nutrient status in the soil and discuss different effects produced by nitrate and ammonium, emphasizing the important role of nitrate for plant growth. Recent studies revealed the molecular mechanism mediating the primary response to nitrate provision and the molecular mechanisms that coordinate the nitrogen response with responses to another macronutrient, phosphorus. We thus discuss these molecular mechanisms as well. 相似文献
5.
Effects of oral exposure of bisphenol A on mRNA expression of nuclear receptors in murine placentae assessed by DNA microarray 总被引:1,自引:0,他引:1
Imanishi S Manabe N Nishizawa H Morita M Sugimoto M Iwahori M Miyamoto H 《The Journal of reproduction and development》2003,49(4):329-336
Bisphenol A (BPA), a candidate endocrine disruptor (ED), is considered to bind to estrogen receptors and to regulate expressions of estrogen responsive genes. It has also shown evidence of affecting the reproductive, immunological and nervous systems of mammalian embryos. However, the effects of BPA on placentae, a central organ of feto-maternal interlocution, are still unclear. To reveal the mechanisms of BPA effects on placentae in mammals, we compared the mRNA expression of 20 nuclear receptors between placentae of vehicle controls and those of orally BPA exposed pregnant mice by a DNA microarray technique. In murine placentae, mRNAs of 11 nuclear receptors were not detected. However, greater than 1.5 fold changes in mRNA expression of nine nuclear receptors between vehicle control and BPA treated mice were noted. Moreover, remarkable changes in mRNA expression of six non-nuclear receptor proteins were induced by BPA exposure. There were various differences in the effects of BPA on the expression of these mRNAs between the placentae with male embryos and those with female embryos. Such embryo-sex dependent differences are interesting and important pointers to understanding of the endocrine disrupting effect of BPA. The present data indicate that BPA affects the expression of nuclear receptor mRNAs in placentae and may disrupt the physiological functions of placentae. 相似文献
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