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Hiromi KEINO Atsushi FUNAHASHI Hiroomi KEINO Chihiro MIWA Masanori HOSOKAWA Yoshihiro HAYASHI Kenji KAWAKITA 《Journal of Equine Science》2009,20(4):79-88
In this study, we applied a novel psycho-educational horseback riding (PEHR) program to
the treatment of four Japanese children with pervasive developmental disorders (PDD) in
order to facilitate the acquisition of verbal and nonverbal communication skills. The
behavioral changes in each child were evaluated using a psychological and behavioral
scale. The scale for evaluating the effect of Human-Equips-Interaction on Mental activity
(HEIM scale) was designed to assess the behavioral improvement of children based on the
following 10 items: Human relationships, Imitation, Emotional expression, Sudden physical
movement, Fixative behavior, Adaptation to change, Visual response, Fear or nervousness,
and Verbal and nonverbal communication. After taking part in the PEHR program for several
months, all subjects showed remarkably improved HEIM scores and marked improvements were
observed in eye contact with others (instructors, side walkers, and leaders) in the riding
area. A statistical difference was found in items 1, 2, 3, 6, 7, 8, and 9. However, no
statistical difference was found in items 4, 5, and 10. As the program progressed, the
children showed enhanced verbal and nonverbal communication skills, and became more
expressive in their emotional and empathetic interaction with their parents. These
observations suggest that the normal functioning of pleasurable emotions and empathy may
facilitate further improvements in joint attention, imitation and empathy, and may result
in successful verbal expression by PDD children. Therefore, horseback riding can play a
very important role in the psycho-educational support required for the communication
ability of PDD children. 相似文献
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Mizuho TASHIRO Yuki HOSOKAWA Hiromi AMAO Atsushi TOHEI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2020,82(12):1757
Hypothermia during anesthetic events is a common adverse effect of anesthesia in laboratory animals. In particular, small rodents such as mice is susceptible to hypothermia during anesthetic events. Therefore, the animals will need additional thermal support by external heating devices during and after anesthesia. In general, the time of recovery from anesthesia is typically longer in case of injectable anesthesia rather than inhalant anesthesia. However, the durations of thermal support have been almost limited to 1 hr from administration of anesthesia in general. Our study objectives are two-fold: 1) to compare the levels of hypothermia induced by injectable anesthesia with medetomidine-midazolam-butorphanol (MMB) and inhalant anesthesia with isoflurane (ISO); 2) to find the adequate durations of thermal support for preventing hypothermia induced by their anesthesia in mice. Adult male ICR mice were anesthetized during 40 min without and with the thermal support for 1 (both anesthetic groups), 2, 3, and 5 hr (in MMB group). Without thermal support, the decrease of body temperature in MMB group were more severe than that in ISO group. The durations of thermal support completely prevented hypothermia at 5 hr-support in MMB group and that at 1 hr-support in ISO group. However, the other short durations did not prevent hypothermia at 1, 2 and 3 hr-support in MMB group. These results suggest that the mice should be received thermal support over 5 hr after injection of MMB anesthesia to prevent hypothermia. 相似文献
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Yasuhiro UNO Masakiyo HOSOKAWA Teruko IMAI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(6):721-724
Arylacetamide deacetylase (AADAC), a microsomal serine esterase, hydrolyzes drugs, such
as flutamide, phenacetin and rifampicin. Because AADAC has not been fully investigated at
molecular levels in cynomolgus macaques, the non-human primate species widely used in drug
metabolism studies, cynomolgus AADAC cDNA was isolated and characterized. The deduced
amino acid sequence, highly homologous (92%) to human AADAC, was more closely clustered
with human AADAC than the dog, rat or mouse ortholog in a phylogenetic tree.
AADAC was flanked by AADACL2 and
SUCNR1 in the cynomolgus and human genomes. Moreover, relatively
abundant expression of AADAC mRNA was found in liver and jejunum, the drug-metabolizing
organs, in cynomolgus macaques, similar to humans. The results suggest molecular
similarities of AADAC between cynomolgus macaques and humans. 相似文献
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Shinji SASAZAKI Daisuke HOSOKAWA Rie ISHIHARA Hiroki AIHARA Kenji OYAMA Hideyuki MANNEN 《Animal Science Journal》2011,82(1):67-72
In the meat industry, correct labeling of beef origins or breed is required to assure quality and safety. This paper describes the development of discrimination markers between Japanese domestic and imported beef from the United States (US) and Australia (AUS) based on a bovine 50K single nucleotide polymorphism (SNP) array using a total of 110 samples: Japanese Black (n = 50), Japanese Holstein (n = 50) and US cattle (n = 10). Genotyping information revealed 1081 SNPs as candidate markers that were polymorphic only in US cattle. The genotyping results by PCR – restriction length polymorphism in Japanese Black (n = 300) and Holstein cattle (n = 146) revealed that 11 SNPs had alleles specific to US cattle. Their allelic frequencies in US cattle (n = 108) ranged from 0.097 to 0.250 with an average of 0.178 and the combined identification probability of US cattle was 0.987. In addition, we also verified the applicability of these US‐specific markers to AUS cattle. Their allelic frequencies in AUS cattle (n = 280) ranged from 0.063 to 0.224 with an average of 0.137 and the combined identification probability of AUS cattle was 0.963. In conclusion, a set of these markers could be useful for discriminating between Japanese domestic and imported beef and would contribute to identify origins and prevent falsified labeling of beef. 相似文献
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Natsuki AKASHI Yusuke MURAHATA Masahumi HOSOKAWA Yoshiaki HIKASA Yoshiharu OKAMOTO Tomohiro IMAGAWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(2):285
We evaluated changes in cardiovascular and renal functions as well as arginine vasopressin (AVP) secretion, with remifentanil and dexmedetomidine administration alone or in combination in sevoflurane-anesthetized dogs. Six healthy adult Beagle dogs received one of the following four treatments in a randomized crossover study: saline (C), remifentanil alone at successively increasing doses (R; 0.15, 0.60, and 2.40 µg/kg/min), dexmedetomidine alone (D; 0.5 µg/kg intravenously for initial 10 min followed by a constant rate infusion at 0.5 µg/kg/hr), and a combination of remifentanil and dexmedetomidine at the above-mentioned doses (RD). Sevoflurane doses were adjusted to 1.5 times of minimum alveolar concentration (MAC) equivalent according to MAC-sparing effects with remifentanil and dexmedetomidine as previously reported. Cardiovascular measurements, renal function data, and plasma AVP concentrations were determined before and every 60 min until 180 min after drug administration as per each treatment. In the R, D and RD, heart rate significantly decreased and mean arterial pressure significantly increased from baseline or with C. Cardiac index significantly decreased and systemic vascular resistance index increased with D and RD. Oxygen extraction ratio, renal blood flow, and glomerular filtration rate were not affected. The plasma AVP concentrations significantly decreased in D and RD, but increased in R. Only in D, the natriuresis was elicited. The combination of remifentanil and dexmedetomidine in sevoflurane-anesthetized dogs was acceptable in terms of the hemodynamics, oxygenation, and renal function. Remifentanil may interfere with dexmedetomidine-induced diuresis and inhibition of AVP secretion. 相似文献
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Daisuke HOSOKAWA Atsushi ISHII Keita YAMAJI Shinji SASAZAKI Kenji OYAMA Hideyuki MANNEN 《Animal Science Journal》2012,83(1):7-13
Differences between average allelic frequencies of genes that relate to traits suggest that it would be evidence of artificial selections. Sliding window approach is a useful method to identify genomic regions that have been differently selected between two breeds. The objective of this study was to identify the divergently selected regions between Japanese Black (JB) and Japanese Holstein (JH) cattle based on genotypic information obtained through a high‐density single nucleotide polymorphism (SNP) panel. After genotyping of 54 001 SNP markers on 100 animals (50 JB and 50 JH), 40 635 SNPs were suitable for the analysis. For each of these SNPs, the absolute difference between allelic frequencies of JB and JH was calculated. In the current study, 10 consecutive SNPs were defined as components of a window. For each window, the average difference in allelic frequency was calculated. This was termed sliding window average difference (SWAD). Among 40 055 windows, we focused on 39 windows with the largest SWAD. This was equivalent to 0.1% of all windows and the SWAD was more than 0.435. Some of these windows overlapped and were distributed in 11 regions. These regions were in good agreement with reported quantitative trait locus, therefore would be selection signatures and good candidates that harbor the causative mutations. 相似文献
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