排序方式: 共有49条查询结果,搜索用时 15 毫秒
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Highly conserved protective epitopes on influenza B viruses 总被引:1,自引:0,他引:1
C Dreyfus NS Laursen T Kwaks D Zuijdgeest R Khayat DC Ekiert JH Lee Z Metlagel MV Bujny M Jongeneelen R van der Vlugt M Lamrani HJ Korse E Geelen Ö Sahin M Sieuwerts JP Brakenhoff R Vogels OT Li LL Poon M Peiris W Koudstaal AB Ward IA Wilson J Goudsmit RH Friesen 《Science (New York, N.Y.)》2012,337(6100):1343-1348
Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses. 相似文献
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Martijn Beukers Federico Vilaplana Grosso George Voorhout 《Veterinary radiology & ultrasound》2013,54(6):610-617
Though identification of lymph nodes is essential in staging cancer patients, little has been reported about the CT features of canine abdominal lymph nodes. The purpose of this retrospective study was to describe the visibility, location, and characteristics of abdominal lymph nodes in abdominal CT studies of dogs considered unlikely to have lymphadenopathy. The relationship between the number of identified lymph nodes and intraabdominal fat ranking, body weight, and slice thickness was also investigated. A total of 19 dogs were included. At least two jejunal lymph nodes and both left and right medial iliac lymph nodes were identified in all dogs. Colic lymph nodes were not identified in any of the dogs. Visualization of all other lymph nodes varied. There were significantly more lymph nodes visible in dogs with more intraabdominal fat (P < 0.0001). No correlation between the number of identified lymph nodes and body weight (P = 0.64) or slice thickness (P = 0.76) was found. Though most of all identified lymph nodes had an elongated shape, a rounded shape was most common in splenic, pancreaticoduodenal, renal, ileocolic and caudal mesenteric lymph nodes. Most lymph nodes had a homogeneous structure before and following the intravenous administration of contrast medium. Some lymph nodes had a slightly irregular structure or were relatively more hyper attenuating in the periphery than centrally before and/or after contrast administration. Mean attenuation before contrast was 37 Hounsfield Units (HU) (range 20–52 HU), and 109 HU after contrast (range 36–223 HU). Findings indicated that the CT visibility, characteristics of different abdominal lymph nodes may be variable in dogs. 相似文献
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Terhem Razak Bin Staats Martijn van Kan Jan A. L. 《European journal of plant pathology / European Foundation for Plant Pathology》2015,142(3):615-624
European Journal of Plant Pathology - Botrytis elliptica is a necrotrophic pathogen that specifically infects Lilium species. Previous records show that B. elliptica collected in the field can... 相似文献
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Oliveira Bruna R. F. Smit Martijn P. J. van Paassen Leon A. Grotenhuis Tim C. Rijnaarts Huub H. M. 《Journal of Soils and Sediments》2017,17(1):286-298
Journal of Soils and Sediments - In delta areas, dense networks of canals have been developed through time and have to be periodically dredged. Lowering the groundwater level in delta areas deepens... 相似文献
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Oliveira Bruna R. F. van Laarhoven Krisjan Smit Martijn P. J. Rijnaarts Huub H. M. Grotenhuis Tim 《Journal of Soils and Sediments》2017,17(2):567-577
Journal of Soils and Sediments - In low lying areas with dense networks of canals for land drainage, sediments accumulate in the waterways and have to be periodically dredged. These adjacent areas... 相似文献
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