排序方式: 共有3条查询结果,搜索用时 15 毫秒
1
1.
2.
Effects of body condition score (BCS) on steroid‐ and eicosanoid‐metabolizing enzyme activity in various mare tissues during winter anoestrus
下载免费PDF全文
![点击此处可从《Reproduction in domestic animals》网站下载免费的PDF全文](/ch/ext_images/free.gif)
MPT Owen EN Ferjak CA Cavinder KJ McCarty KC Yankey CG Hart DD Burnett TTN Dinh CO Lemley 《Reproduction in domestic animals》2018,53(2):296-303
The objective of this study was to determine the activity of steroid‐ and eicosanoid‐metabolizing enzymes in horses with varying BCSs. The BCSs of twenty non‐pregnant, anoestrous mares were determined prior to euthanasia, and tissue samples were collected from the liver, kidney, adrenal gland, ovary and endometrium. Cytochrome P450 1A (CYP1A), 2C (CYP2C), 3A (CYP3A) and uridine 5′‐diphospho‐glucuronosyltransferase (UGT) activities were determined using luminogenic substrates. The MIXED procedure of SAS was used to test the effect of BCS on enzyme activity and differences between tissues. Activity of CYP1A in adrenals was increased (p ≤ .05) in BCS 5 versus BCSs 4 and 6. Activity of CYP1A in the liver was increased (p = .05) in BCS 4 versus BCSs 5 and 6. Activity of CYP1A was 100‐fold greater (p < .0001) in the liver than in the adrenal, ovary and kidney. Activity of CYP2C was 100‐fold greater (p < .0001) in the liver than in the adrenal, ovary and endometrium. Activity of CYP3A was only detectable in the liver. Activity of UGT in the kidney was decreased (p = .02) in BCS 4 versus BCSs 5 and 6. Activity of UGT was threefold greater (p < .0001) in the liver than in the kidney, whereas activity of UGT was ninefold greater (p < .0001) in the kidney than in the ovary and endometrium. In general, BCS did not alter the activity of steroid‐ and eicosanoid‐metabolizing enzymes in horses. However, tissue differences in these enzymes indicated abundant hepatic metabolism in horses, which is similar to other livestock species. 相似文献
3.
Objective— To describe a surgical technique for total knee replacement (TKR) in dogs with severe osteoarthritis (OA) and report 1-year outcome.
Study Design— Prospective clinical case study.
Animals— Dogs (n=6) with severe stifle OA.
Methods— Preoperative and postoperative evaluations were compared after 6 dogs had TKR. Data gathered included radiographs, goniometric measures of passive range of motion, ground reaction forces, and girth measurements of the thigh before surgery and at 6 weeks, 3 months, 6 months, and 1 year.
Results— Stifle extension and excursion angles were significantly improved by 3 months after TKR. Mean peak vertical force and impulse were significantly improved by 6 months.
Conclusions— TKR is a viable treatment option for dogs with severe stifle OA.
Clinical Relevance— With continued refinement of surgical technique, instrumentation, and implants, TKR could become a reliable treatment for dogs with disabling, painful nonseptic stifle OA. 相似文献
Study Design— Prospective clinical case study.
Animals— Dogs (n=6) with severe stifle OA.
Methods— Preoperative and postoperative evaluations were compared after 6 dogs had TKR. Data gathered included radiographs, goniometric measures of passive range of motion, ground reaction forces, and girth measurements of the thigh before surgery and at 6 weeks, 3 months, 6 months, and 1 year.
Results— Stifle extension and excursion angles were significantly improved by 3 months after TKR. Mean peak vertical force and impulse were significantly improved by 6 months.
Conclusions— TKR is a viable treatment option for dogs with severe stifle OA.
Clinical Relevance— With continued refinement of surgical technique, instrumentation, and implants, TKR could become a reliable treatment for dogs with disabling, painful nonseptic stifle OA. 相似文献
1