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I. Hajek F. Kettner V. Simerdova C. Rusbridge P. Wang B. A. Minassian V. Palus 《The Journal of small animal practice》2016,57(11):650-652
Lafora disease is a fatal genetic disorder characterised by neurotoxic deposits of malformed insoluble glycogen. In humans it is caused by mutation in the EPM2A or NHLRC1 genes. There is a known mutation in miniature wirehaired dachshunds which has not been documented in other dog breeds, including beagles, in which the disease is relatively commonly reported. This case report describes the causative defect in two affected beagles, namely the same massive expansion as in miniature wirehaired dachshunds of a 12‐nucleotide repeat sequence that is unique to the canine NHLRC1 gene. This is the first mutation described in beagles with Lafora disease, and so far the only Lafora disease genetic variant in dogs. 相似文献
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跃进农场根据多年的育苗经验 ,通过正确使用辛硫磷 ,在防治地下害虫方面取得了较为显著的效果。1 苗圃主要地下害虫种类及虫源金龟子 (螬 )、蝼蛄、小地老虎号称苗圃三大地下害虫 ,这些地下害虫的主要来源渠道为 :(1)老圃地的残枝败叶产生虫卵 ,久而久之泛滥成灾 ,加之防范措施不利 ,土壤老化滋生杂多的虫卵 ,使其产生虫源 ;(2 )未能及时翻耙 ,或翻耙深度不够 ,使地下虫卵长年繁殖 ,产生大量的幼虫 ;(3)圃地草荒严重 ,各类虫害频频发生 ,使潜藏在杂草内的虫卵和病菌繁衍生息 ;(4 )在改土施肥过程中使用的生土和未腐熟的肥料中带有虫卵 ,产… 相似文献
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Kettner F Côté E Kirberger RM 《Journal of the American Animal Hospital Association》2005,41(6):406-412
An 11-month-old, female Scottish terrier was presented with a history of a heart murmur. The electrocardiogram showed signs of left ventricular enlargement, and radiography confirmed generalized cardiomegaly. Echocardiography revealed four equally sized aortic valve cusps. A ventricular septal defect, with systolic left-to-right shunting, and aortic regurgitation into both ventricles were also present. The dog was free of clinical signs 1 year after diagnosis. 相似文献
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以草麻黄幼苗的幼茎和下胚轴为外植体,采用不同激素组合及浓度配比的MS培养基进行愈伤组织的诱导。结果表明:草麻黄幼茎愈伤组织诱导的最佳培养基为MS+1.1mg/L 2,4-D+0.2 mg/L KT。在MS+2 mg/L 6-BA +0.2 mg/L IAA的培养基上,下胚轴的诱导率高于幼茎。愈伤组织继代增殖的最佳培养基为MS+0.5mg/L 2,4-D +0.2 mg/L 6-BA,在其上继续生长,形成淡绿色、致密的愈伤组织,愈伤组织细胞主要为二倍体,也有少量的亚二倍体细胞和其它倍性细胞产生。 相似文献
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Neuronal population coding of movement direction 总被引:41,自引:0,他引:41
Although individual neurons in the arm area of the primate motor cortex are only broadly tuned to a particular direction in three-dimensional space, the animal can very precisely control the movement of its arm. The direction of movement was found to be uniquely predicted by the action of a population of motor cortical neurons. When individual cells were represented as vectors that make weighted contributions along the axis of their preferred direction (according to changes in their activity during the movement under consideration) the resulting vector sum of all cell vectors (population vector) was in a direction congruent with the direction of movement. This population vector can be monitored during various tasks, and similar measures in other neuronal populations could be of heuristic value where there is a neural representation of variables with vectorial attributes. 相似文献
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Leisewitz AL Blaylock RS Kettner F Goodhead A Goddard A Schoeman JP 《Journal of the South African Veterinary Association》2004,75(1):7-13
Cases of snakebite envenomation are frequently presented to veterinary practitioners in southern Africa. Despite this, no published guidelines exist on how this medical emergency should be managed. Southern African snake venoms can be classified into 3 main types based on the main mechanism of venom action and clinical presentation. A polyvalent antivenom is manufactured in South Africa and contains antibodies against the most important southern African snake venoms. The cytotoxic venoms are represented mainly by the puff-adder (Bitis arietans), Mozambique spitting cobra (Naja mossabica), black-necked spitting cobra (Naja nigricollis) (in the Western Cape and Namibia) and the stiletto snake (Atractaspis bibronii). These venoms may cause dramatic local swelling, high morbidity and low mortality and infrequently require the use of antivenom for survival (the only cytotoxic venoms used to prepare the antivenom are the puff-adder and Mozambique spitting cobra). The neurotoxic venoms (represented chiefly by the non-spitting cobras and mambas) cause high mortality due to rapid onset of paresis and require antivenom and mechanical ventilatory support which is life-saving. The boomslang (Dispholidus typus) and the vine snake (coagulopathic venom) rarely bite humans but dogs may be bitten more frequently. These venoms cause a consumption coagulopathy and successful treatment of boomslang bites requires the use of snake species-specific monovalent antivenom. There is no antivenom available for treating vine snake (Thelotornis capensis), berg adder (Bitis atropos), night adder (Causus spp.), stiletto snake and other lesser adder bites. There are some important differences between the way snakebites are managed in humans and dogs. 相似文献