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Ito H Nara H Inoue-Murayama M Shimada MK Koshimura A Ueda Y Kitagawa H Takeuchi Y Mori Y Murayama Y Morita M Iwasaki T Ota K Tanabe Y Ito S 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2004,66(7):815-820
Various canine breeds are remarkably different from each other not only in their sizes and shapes but also in behavioral traits, suggesting that some of them are under genetic control. Although dopaminergic neurotransmission system is considered to affect animal behavior, little is known about related genes in canine. Relations between specific alleles in polymorphic regions of the dopamine receptor D4 gene (DRD4) and personality or psychiatric disorders have been reported in humans, and we first found polymorphism in exon III region of the gene in 4 canine breeds. In this study we surveyed allele frequency distribution in 23 breeds including a total of 1,535 unrelated individuals. In exon III, 8 alleles including a novel allele were identified. A group of breeds in which the alleles 447b, 498 and 549 were frequent tended toward high scores in aggression-related behavioral traits than that with frequent alleles 435 and 447a. Moreover, a polymorphism based on 24 bp insertion/deletion was found in exon I region for the first time in dogs. This information may be of use for candidate gene studies of behavioral variation in dogs. 相似文献
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Hidetoshi NARA Miho INOUE-MURAYAMA Akiko KOSHIMURA Akinori SUGIYAMA Yuichi MURAYAMA Masami MAEJIMA Yuko UEDA Hideyuki ITO Ettore RANDI Heui-Soo KIM Ji-Hong HA Hitoshi KITAGAWA Yukari TAKEUCHI Yuji MORI Toshiroh IWASAKI Mitsuo MORITA Katuaki ÔTA Shin'ichi ITO 《Animal Science Journal》2005,76(1):81-86
Various dog breeds are remarkably different from each other not only in their sizes and shapes but also in behavioral traits, suggesting that some of these characteristics are under genetic control. However, little is known about genes related to behavioral traits in canine species. In humans, it has been reported that the dopamine receptor D4 gene (DRD4) includes polymorphism at several regions that relate to personality or psychiatric disorders. In an earlier study by the authors of the present study, the polymorphisms in canine DRD4 exon III and exon I regions were reported. In the present study, a novel polymorphism in canine DRD4 intron II was found based on a 17 base pair insertion/deletion, and the two alleles detected were named P (shorter allele) and Q (longer allele). The allelic distribution in 28 breeds of dog, including a total of 1114 unrelated individuals, were then investigated. Both P and Q alleles were detected in most of the breeds investigated; however, the frequencies of P and Q differed greatly between breeds. With respect to classification based on breed origin, P and Q alleles were frequent in Occidental and Oriental breeds, respectively. Furthermore, two subspecies of wolves, the ancestors of dogs, were analyzed for the comparison of allele frequencies with dogs, and the P allele was predominant in both European and Chinese wolves. 相似文献
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