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A 26-year-old, wild caught, male Malayan tapir at the Miami Metrozoo with bilateral corneal papillomas was serially immobilized and given subconjunctival injections of fluorouracil. Over the course of 17 weeks five bilateral injections of 25 mg fluorouracil were given. This treatment caused regression of the corneal lesions as evidenced by decreased lesion diameter, decreased corneal vascularity, increased corneal clarity, and improved visual function. No adverse drug effects were observed. 相似文献
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K F Karpinski 《Journal of the Association of Official Analytical Chemists》1989,72(6):931-935
The acceptability of a new analytical method is generally assessed in terms of repeatability and reproducibility estimates derived from a collaborative study. Procedures are presented for calculating confidence intervals and operating characteristic curves for acceptance criteria based on the repeatability and reproducibility estimates. Comparisons of the reliability of estimates are provided for various numbers of collaborators. With a small number of collaborators, the estimates of reproducibility are not reliable and decisions regarding acceptability of a method will be heavily based on the method's repeatability rather than the property of most interest, namely, the reproducibility of the method. 相似文献
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KK Adamama-Moraitou D Pardali NN Prassinos LG Papazoglou D Makris KI Gourgoulianis N Papaioannou TS Rallis 《Australian veterinary journal》2010,88(9):351-356
Objectives To investigate whether there are any changes in the tidal breathing flow volume loop (TBFVL) in calm, non-dyspnoeic dogs with intratracheal masses. Methods We compared 4 dogs with intratracheal masses (group 1) with 10 healthy dogs (group 2). Routine clinical and laboratory examinations of the dogs were unremarkable, except for episodic upper respiratory obstructive signs in the dogs in group 1. Lateral radiography of the neck and thorax showed that group 1 dogs had masses that appeared to protrude into the tracheal lumen. Tracheoscopy and surgery or necropsy was performed to confirm the presence of the mass. Arterial blood gas and TBFVL analysis was carried out in all dogs to assess respiratory status. Results The shape of the TBFVL for dogs in group 1 was narrower and ovoid compared with that for the group 2 dogs. Tidal volume and expiratory and inspiratory times were significantly reduced, whereas the respiratory rate was increased for dogs in group 1 compared with dogs in group 2. Arterial blood gas analysis was unremarkable for all dogs. Conclusions TBFVL is a non-invasive technique that is easy to perform and well tolerated by dogs. In the absence of abnormalities detected by routine diagnostic evaluations and arterial blood gas analysis in dogs with intratracheal masses, the TBFVL contributes to the definition of the physiologic status of the airways at the time of testing, and results suggests that these dogs breathe quite normally when they are calm and non-dyspnoeic. 相似文献
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LG PAPAZOGLOU GD BRELLOU PL PAPADOPOULOU AK DESSIRIS 《Australian veterinary journal》2005,83(1-2):37-37