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K W Jericho 《The Canadian veterinary journal. La revue veterinaire canadienne》1979,20(11):333-335
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Electrophoretic and Chemical Studies on Sera of Swine Following the Feeding of Toxic Groundnut Meal 总被引:1,自引:1,他引:0 下载免费PDF全文
E. Annau A. H. Corner S. E. Magwood K. Jericho 《Canadian journal of veterinary research》1964,28(11):264-268,269
The consumption of toxic groundnut meal by swine leads to marked alterations in their electrophoretic serum patterns. Experiments carried out by chemical assays and by the moving boundary electrophoretic method of Tiselius and Smithies' starch gel electrophoresis showed a relative decrease in the albumin, alpha1-, alpha2-, and beta globulins, while gamma globulin appeared to be considerably increased. 相似文献
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The onset of protection offered by intranasal vaccination with attenuated bovine herpesvirus-1 (BHV-1) was studied in 18 calves given a virulent BHV-1 aerosol challenge inoculum and an aerosol challenge exposure to Pasteurella haemolytica. Calves challenge exposed with virus 3, 7, 11, 15, or 19 days after vaccination and challenge exposed 4 days later with Pasteurella haemolytica did not develop viral-bacterial pneumonia, whereas 2 of 3 control calves died of fibrinous bronchopneumonia 40 and 60 hours after the bacterial aerosol and the 3rd control calf had similar lesions. All vaccinated and control calves had detectable amounts of interferon at the time of viral challenge exposure. Protection was observed before detection of neutralizing antibodies to BHV-1 in nasal secretions or in serum. Protection was therefore present from day 3 through day 19 after vaccination, but the mechanism could not be explained completely by neutralizing antibody or interferon. 相似文献
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Effect of viral dose on experimental pneumonia caused by aerosol exposure of calves to bovine herpesvirus 1 and Pasteurella haemolytica. 总被引:1,自引:1,他引:0 下载免费PDF全文
The effect of various aerosol doses of bovine herpesvirus 1, followed four days later by aerosol exposure to a constant level of Pasteurella haemolytica, was studied in 16 crossbred Hereford range calves. A Collision nebulizer was used to generate aerosols from virus suspensions with concentrations of 10(8.2) (high), 10(5.2) (moderate) or 10(2.2) (low) TCID50/mL. The bacterial suspension contained 10(7) colony forming units/mL. Control calves exposed only to P. haemolytica developed no pulmonary lesions. Calves in the low, moderate and high virus exposure groups developed lobular areas of atelectasis; in addition, one calf in the moderate and all four in the high virus exposure group developed fibrinous pneumonia. One of the latter calves died. The 50% effective dose for fibrinous pneumonia under these experimental conditions was 10(6.0) TCID50 bovine herpesvirus 1/mL of suspension in the nebulizer reservoir, and approximately 10(4.0) infectious units inhaled per calf. 相似文献
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Failure of a Subunit Bovine Herpesvirus 1 Vaccine to Protect Against Experimental Respiratory Disease in Calves 总被引:1,自引:1,他引:0 下载免费PDF全文
In two experiments in which 31 calves were used, a bovine herpesvirus 1 subunit vaccine previously shown to elicit a strong immunological response in adult cattle failed to do so in younger animals and failed to protect against pneumonia caused by sequential exposure to virulent bovine herpesvirus 1 and Pasteurella haemolytica aerosols. One of the experimental groups had been previously inoculated with a live commercial vaccine but even this failed to elicit a strong immunological response. These results indicate that the calves were in a refractory state when immunized and may explain why similar vaccine failures occur in the field. 相似文献