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1.
In humans, the empty sella is defined as herniation of the subarachnoidal space into the sella turcica with invisible (total empty sella) or reduced (partial empty sella) hypophyseal size. An empty sella can be associated with endocrine disturbances. The purpose of this study was to determine if the empty sella exists in dogs or cats and whether it is associated with endocrinopathy or hydrocephalus. Archived magnetic resonance images of the head of 370 dogs and 77 cats were re-evaluated specifically for the presence or absence of the pituitary gland. Hypophyseal tissue filling more than 50% of the sella was considered normal, between 30% and 50% was defined as partial empty sella and less than 30% was defined as total empty sella. In patients with an empty sella, and in all other imaged dogs of the affected breeds, the ventricle to brain ratio was measured. In patients with an empty sella, the medical record was searched for evidence of endocrinopathy. No cat had an empty sella but 11 dogs (3%) had a small or missing hypophysis. Seven of these dogs had a ventricle to brain ratio greater than 15%. Only small dogs (mean weight of 6.7 kg) were affected. One dog with an empty sella had signs of central hyperadrenocorticism while the other 10 had no sign of endocrinopathy. We conclude that the empty sella exists in dogs but is not generally associated with endocrinopathy. 相似文献
2.
PETER BÖTTCHER Dr med vet Diplomate ECVS MARKUS ZEISSLER DVM JOHANN MAIERL PhD Dr med vet VERA GREVEL Prof. Dr med vet Diplomate ECVS GERHARD OECHTERING Prof. Dr med vet Diplomate ECVAA 《Veterinary surgery : VS》2009,38(6):696-704
Objective— To characterize donor and recipient sites for autologous osteochondral transplantation in the canine stifle joint with respect to split-line pattern and cartilage thickness.
Study Design— In vitro study.
Sample Population— Stifle joints (n=30) of dogs >20 kg.
Methods— Collagen network orientation of the hyaline cartilage coverage of the distal femur was assessed using split-line technique (n=10). Cartilage thickness was measured radiographically on osteochondral plugs harvested at the abaxial and axial surfaces of the femoropatellar joint (n=15), the most proximal abaxial aspect of the medial condyle (CO; n=5) and at both femoral condyles (n=15).
Results— Cartilage within the femoropatellar joint and both femoral condyles had mostly transversely orientated pattern of split-lines. Abaxial to the femoropatellar joint split-lines were absent. All donor sites had significantly thinner cartilage than the medial condyle (CM). Only the distal trochlea had cartilage thickness comparable to the lateral condyle (CL). The thinnest cartilage was found abaxial to the femoropatellar joint followed by CO, which was ∼2–3 times thinner than the cartilage at both condyles.
Conclusions— None of the investigated donor sites provided transplants of comparable cartilage thickness to CM. Transplants from within the femoropatellar joint should be harvested in priority as they reach cartilage morphology comparable to CL.
Clinical Relevance— Adjusting for cartilage thickness and split-line pattern may improve long-term outcome after autologous osteochondral transplantation. But surface curvature and donor-site morbidity have to be considered as well when choosing the most suitable donor site. 相似文献
Study Design— In vitro study.
Sample Population— Stifle joints (n=30) of dogs >20 kg.
Methods— Collagen network orientation of the hyaline cartilage coverage of the distal femur was assessed using split-line technique (n=10). Cartilage thickness was measured radiographically on osteochondral plugs harvested at the abaxial and axial surfaces of the femoropatellar joint (n=15), the most proximal abaxial aspect of the medial condyle (CO; n=5) and at both femoral condyles (n=15).
Results— Cartilage within the femoropatellar joint and both femoral condyles had mostly transversely orientated pattern of split-lines. Abaxial to the femoropatellar joint split-lines were absent. All donor sites had significantly thinner cartilage than the medial condyle (CM). Only the distal trochlea had cartilage thickness comparable to the lateral condyle (CL). The thinnest cartilage was found abaxial to the femoropatellar joint followed by CO, which was ∼2–3 times thinner than the cartilage at both condyles.
Conclusions— None of the investigated donor sites provided transplants of comparable cartilage thickness to CM. Transplants from within the femoropatellar joint should be harvested in priority as they reach cartilage morphology comparable to CL.
Clinical Relevance— Adjusting for cartilage thickness and split-line pattern may improve long-term outcome after autologous osteochondral transplantation. But surface curvature and donor-site morbidity have to be considered as well when choosing the most suitable donor site. 相似文献
3.
DANIELA GORGAS PATRIC LUDER JOHANN LANG MARCUS G. DOHERR GOTTLIEB UELTSCHI PATRICK KIRCHER 《Veterinary radiology & ultrasound》2009,50(2):208-214
Nuclear bone scintigraphy is commonly used in the diagnosis of sacroiliac disease in horses. The aim of the present retrospective study was to determine if there was an association between radiopharmaceutical uptake pattern and radiographic appearance of the sacroiliac region in horses. Seventy-nine horses undergoing bone scintigraphy with Tc-99 m-HDP and radiography of the pelvis because of lameness or poor performance were studied. Subjective and semiquantitative methods were used to characterize and compare radiopharmaceutical uptake between horses. Ventrodorsal radiographs of the region were obtained and were evaluated. Subjectively, 70 horses (88.6%) had an abnormal uptake pattern. In nine horses, the sacroiliac region was normal (11.4%). There was no association between subjective evaluation of the scintigraphic images and semiquantitative methods. There was a significant association between radiopharmaceutical uptake and conformation (T- or Y-like form) and shape (butterfly-, wing-, leaf-, or horn-like) of the sacrum. The radiopharmaceutical uptake of the tubera sacralia was significantly higher in males (left side P =0.002, right side P =0.003). In conclusion, the conformation of the sacrum may play an important role in the scintigraphic appearance and may be the cause of increased radiopharmaceutical uptake. 相似文献
4.
SANDRA MARTIG MARTIN KONAR HUGO G. SCHMÖKEL UELI RYTZ DAVID SPRENG JÜRG SCHEIDEGGER BIRGIT HÖHL PATRICK R. KIRCHER JULIE BOISCLAIR JOHANN LANG 《Veterinary radiology & ultrasound》2006,47(6):515-522
Little is known about the magnetic resonance imaging (MRI) appearance of canine meniscal lesions. The aim of this study is to describe the MR appearance of meniscal lesions in dogs with experimentally induced cranial cruciate ligament (CCL) deficiency. The pilot study revealed dogs weighing approximately 10 kg to be too small for meniscal evaluation on low-field MRI. In the main study, dogs weighing approximately 35 kg were used. The left CCL was transected and low-field MRI was performed regularly until 13 months post-surgery. Normal menisci were defined as grade 0. Intrameniscal lesions not reaching any surface corresponded to grade 1 if focal and to grade 2 if linear or diffuse. Grade 3 lesions consisted in linear tears penetrating a meniscal surface. Grade 4 lesions included complex signal changes or meniscal distortion. Between 2 and 13 months post-surgery, all dogs developed grade 4 lesions in the medial meniscus. Most of them corresponded to longitudinal or bucket handle tears on arthroscopy and necropsy. Two dogs showed grade 3 lesions reaching the tibial surface of the lateral meniscus on MRI but not in arthroscopy. Such tears are difficult to evaluate arthroscopically; MRI provides more accurate information about the tibial meniscal surface. Grades 1 and 2 lesions could not be differentiated from presumably normal menisci with our imaging technique. An MRI grading system better adapted to canine lesions has yet to be developed. MRI is a helpful tool for the diagnosis of complete tears in the canine meniscus, especially in larger dogs. 相似文献
5.
INO CURIK JOHANN SÖLKNER & NIKOLA STIPIC 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2002,119(2):101-115
Considering the effects of selection, dominance, epistasis and linkage, a stochastic computer simulation was performed to study how well inbreeding coefficients calculated from pedigree (fped ) and genotypic frequencies (fhet ) correspond to the inbreeding coefficient that is defined as the proportion of autozygous loci in the modelled genome (i.e. the level of autozygosity, faut ). Although in random mating populations all three inbreeding coefficients show almost (with slight deviations in models with two loci) the same expectation, they represent three separate variables. First, faut , fped and fhet responded differently to selection, dominance, epistasis and linkage. Second, they did not have the same standard deviations, which means that the effects of random drift, especially in models under selection, were not affecting all three coefficients in the same way. Finally, they were not always defined in the same domain. With selection as the most important factor responsible for the observed discrepancies, the bias (discrepancy) was present in both directions, thus leading to overestimation or underestimation of the observed level of autozygosity depending on the genetic model, linkage and initial gene frequency. Variation of the autozygosity level (between replicates) was increased notably in models with additive inheritance under selection and was an additional potential source of bias. Thus, when the trait is, to a large extent, controlled by a finite number of loci and when selection is present, the bias in the estimation of the autozygosity is likely to occur and caution is necessary whenever conclusions are based on inbreeding coefficients estimated from the pedigree or decrease in heterozygosity. 相似文献
6.
BARBARA B. BOCKSTAHLER DVM ROLAND GESKY DVM MARION MUELLER DVM JOHANN G. THALHAMMER DVM PhD CHRISTIAN PEHAM DME I. PODBREGAR MSc 《Veterinary surgery : VS》2009,38(6):754-761
Objective— To describe the activity pattern of the vastus lateralis muscle in dogs at walk measured by surface electromyography (EMG) in relation to kinematics and kinetics of the pelvic limb.
Study Design— Experimental.
Animals— Malinois dogs (n=11).
Methods— Dogs (mean ± SD age, 5.5 ± 2.9 years; weight, 27.3 ± 3.8 kg; shoulder height, 62.7 ± 3.3 cm) walked on a treadmill system with integrated force plates, which allowed simultaneous analysis of kinematics, kinetics, and EMG data from all limbs. The maxima, minima, and their time of occurrence in the motion cycle of the EMG and the pelvic limb kinematics and kinetics were calculated; correlations between joint movement patterns, ground reaction forces (GRF), and activity pattern of the muscle group were investigated.
Results— The vastus lateralis muscle had an activity pattern with 2 peaks and a close positive correlation with GRF. The 1st peak occurred in early stance, followed by a decrease in activity during mid-stance. The 2nd peak occurred directly before the quick activity decrease in late stance phase, reaching its minimum early in swing phase.
Conclusions— These results suggest that the vastus lateralis muscle supports the vertical position and elevation of the pelvis during stance and push-off. During early stance, the muscle acts as a coantagonist to the hamstring muscle group and the gastrocnemius muscle, and restrains flexion during the late stance.
Clinical Relevance— Results of this study could enhance diagnosis of locomotor system disorders and facilitate monitoring effects of treatments (e.g., therapeutic exercises) on gait ability and muscle function. 相似文献
Study Design— Experimental.
Animals— Malinois dogs (n=11).
Methods— Dogs (mean ± SD age, 5.5 ± 2.9 years; weight, 27.3 ± 3.8 kg; shoulder height, 62.7 ± 3.3 cm) walked on a treadmill system with integrated force plates, which allowed simultaneous analysis of kinematics, kinetics, and EMG data from all limbs. The maxima, minima, and their time of occurrence in the motion cycle of the EMG and the pelvic limb kinematics and kinetics were calculated; correlations between joint movement patterns, ground reaction forces (GRF), and activity pattern of the muscle group were investigated.
Results— The vastus lateralis muscle had an activity pattern with 2 peaks and a close positive correlation with GRF. The 1st peak occurred in early stance, followed by a decrease in activity during mid-stance. The 2nd peak occurred directly before the quick activity decrease in late stance phase, reaching its minimum early in swing phase.
Conclusions— These results suggest that the vastus lateralis muscle supports the vertical position and elevation of the pelvis during stance and push-off. During early stance, the muscle acts as a coantagonist to the hamstring muscle group and the gastrocnemius muscle, and restrains flexion during the late stance.
Clinical Relevance— Results of this study could enhance diagnosis of locomotor system disorders and facilitate monitoring effects of treatments (e.g., therapeutic exercises) on gait ability and muscle function. 相似文献
7.
JEANNINE BRUNNER SINGH ANNA OEVERMANN JOHANN LANG MARC VANDEVELDE MARCUS DOHERR DIANA HENKE DANIELA GORGAS 《Veterinary radiology & ultrasound》2011,52(6):619-626
Certain magnetic resonance (MR) enhancement patterns are often considered to be associated with a specific diagnosis but experience shows that this association is not always consistent. Therefore, it is not clear how reliably contrast enhancement patterns correlate with specific tissue changes. We investigated the detailed histomorphologic findings of intracranial lesions in relation to Gadodiamide contrast enhancement in 55 lesions from 55 patients, nine cats, and 46 dogs. Lesions were divided into areas according to their contrast enhancement; therefore 81 areas resulted from the 55 lesions which were directly compared with histopathology. In 40 of 55 lesions (73%), the histomorphologic features explained the contrast enhancement pattern. In particular, vascular proliferation and dilated vessels occurred significantly more often in areas with enhancement than in areas without enhancement (P=0.044). In 15 lesions, there was no association between MR images and histologic findings. In particular, contrast enhancement was found within necrotic areas (10 areas) and ring enhancement was seen in lesions without central necrosis (five lesions). These findings imply that necrosis cannot be differentiated reliably from viable tissue based on postcontrast images. Diffusion of contrast medium within lesions and time delays after contrast medium administration probably play important roles in the presence and patterns of contrast enhancement. Thus, histologic features of lesions cannot be predicted solely by contrast enhancement patterns. 相似文献
8.
FRANCK FORTERRE DVM Diplomate ECVS DANIELA GORGAS DVM Diplomate ECVDI MARK DICKOMEIT DVM ANDRE JAGGY DVM Diplomate ECVN JOHANN LANG DVM Diplomate ECVDI DAVID SPRENG DVM Diplomate ECVS & ACVECC 《Veterinary surgery : VS》2010,39(2):165-172
Objective— To investigate causes of the lack of clinical improvement after thoracolumbar disc surgery. Study Design— Case–control magnetic resonance imaging (MRI) study. Animals— Chondrodystrophic dogs with acute thoracolumbar disc disease treated by hemilaminectomy: 10 that had no short‐term clinical improvement and 12 with “normal” clinical improvement. Methods— Dogs that had surgery for treatment of intervertebral disc extrusion (2003–2008) where thoracolumbar disc disease was confirmed by MRI were evaluated to identify dogs that had lack of clinical improvement after surgery. Ten dogs with delayed recovery or clinical deterioration were reexamined with MRI and compared with 12 dogs with normal recovery and MRI reexamination after 6 weeks (control group). Results— Of 173 dogs, 10 (5.8%) had clinical deterioration within 1–10 days after surgery. In 8 dogs, residual spinal cord compression was identified on MRI. Bleeding was present in 1 dog. In 3 dogs, the cause was an incorrect approach and insufficient disc material removal. In 3 dogs, recurrence occurred at the surgical site. In 1 dog, the centrally located extruded material was shifted to the contralateral side during surgery. These 8 dogs had repeat surgery and recovery was uneventful. In 2 dogs, deterioration could not be associated with a compressive disc lesion. Hemorrhagic myelomalacia was confirmed by pathologic examination in 1 dog. The other dog recovered after 6 months of conservative management. Conclusion— Delayed postsurgical recovery or deterioration is commonly associated with newly developed and/or remaining compressive disc lesion. Clinical Relevance— We recommend early MRI reexamination to assess the postsurgical spinal canal and cord, and to plan further therapeutic measures in chondrodystrophic dogs with delayed recovery after decompressive hemilaminectomy for thoracolumbar disc disease. 相似文献
9.
MARTA PEKARKOVA PATRICK R. KIRCHER MARTIN KONAR JOHANN LANG CAROLINE TESSIER 《Veterinary radiology & ultrasound》2009,50(4):392-397
The purpose of the present study was to describe normal magnetic resonance (MR) imaging anatomy of the equine larynx and pharynx and to present the optimal protocol, sequences, and possible limitations of this examination technique. Using a 0.3 T unit, the laryngeal and pharyngeal regions was imaged in two horses. The protocol consisted of sagittal and transverse T2-weighted (T2w) fast spin echo, transverse T1-weighted (T1w) spin echo, and dorsal high-resolution T1w gradient echo (both pre- and postcontrast enhancement) sequences. Euthanasia was performed at the end of the imaging procedure. Macroscopic anatomy of the cadaver sections were compared with the MR images in transverse, midsagittal, and parasagittal planes. There was good differentiation of anatomic structures, including soft tissues. The laryngeal cartilages, hyoid apparatus, and upper airway muscle groups with their attachments could be clearly identified. However, it was not always possible to delineate individual muscles in each plane. Most useful were both T2w and T1w transverse sequences. Intravenous application of contrast medium was helpful to identify blood vessels. The MR images corresponded with the macroscopic anatomy of cadaver sections. 相似文献
10.
KATHARINA U. HEDIGER DVM STEPHEN J. FERGUSON DVM PhD PHILIPPE GEDET Dipl. Ing. RE BUSATO DVM MSc PD FRANCK FORTERRE DVM Diplomate ECVS SAMUEL ISLER DVM RETO BARMETTLER DVM JOHANN LANG DVM Diplomate ECVDI 《Veterinary surgery : VS》2009,38(7):874-880
Objective— To determine stiffness and load–displacement curves as a biomechanical response to applied torsion and shear forces in cadaveric canine lumbar and lumbosacral specimens.
Study Design— Biomechanical study.
Animals— Caudal lumbar and lumbosacral functional spine units (FSU) of nonchondrodystrophic large-breed dogs (n=31) with radiographically normal spines.
Methods— FSU from dogs without musculoskeletal disease were tested in torsion in a custom-built spine loading simulator with 6 degrees of freedom, which uses orthogonally mounted electric motors to apply pure axial rotation. For shear tests, specimens were mounted to a custom-made shear-testing device, driven by a servo hydraulic testing machine. Load–displacement curves were recorded for torsion and shear.
Results— Left and right torsion stiffness was not different within each FSU level; however, torsional stiffness of L7-S1 was significantly smaller compared with lumbar FSU (L4-5–L6-7).
Ventral/dorsal stiffness was significantly different from lateral stiffness within an individual FSU level for L5-6, L6-7, and L7-S1 but not for L4-5. When the data from 4 tested shear directions from the same specimen were pooled, level L5-6 was significantly stiffer than L7-S1.
Conclusions— Increased range of motion of the lumbosacral joint is reflected by an overall decreased shear and rotational stiffness at the lumbosacral FSU.
Clinical Relevance— Data from dogs with disc degeneration have to be collected, analyzed, and compared with results from our chondrodystrophic large-breed dogs with radiographically normal spines. 相似文献
Study Design— Biomechanical study.
Animals— Caudal lumbar and lumbosacral functional spine units (FSU) of nonchondrodystrophic large-breed dogs (n=31) with radiographically normal spines.
Methods— FSU from dogs without musculoskeletal disease were tested in torsion in a custom-built spine loading simulator with 6 degrees of freedom, which uses orthogonally mounted electric motors to apply pure axial rotation. For shear tests, specimens were mounted to a custom-made shear-testing device, driven by a servo hydraulic testing machine. Load–displacement curves were recorded for torsion and shear.
Results— Left and right torsion stiffness was not different within each FSU level; however, torsional stiffness of L7-S1 was significantly smaller compared with lumbar FSU (L4-5–L6-7).
Ventral/dorsal stiffness was significantly different from lateral stiffness within an individual FSU level for L5-6, L6-7, and L7-S1 but not for L4-5. When the data from 4 tested shear directions from the same specimen were pooled, level L5-6 was significantly stiffer than L7-S1.
Conclusions— Increased range of motion of the lumbosacral joint is reflected by an overall decreased shear and rotational stiffness at the lumbosacral FSU.
Clinical Relevance— Data from dogs with disc degeneration have to be collected, analyzed, and compared with results from our chondrodystrophic large-breed dogs with radiographically normal spines. 相似文献