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1.
In the domestic pig, a circadian rhythm of plasma cortisol occurs, with greatest concentrations in the morning and lowest concentrations in the afternoon. However, photic entrainment of the rhythms of ACTH and melatonin in pigs have not been defined clearly. This experiment was designed to evaluate free-running rhythms of ACTH, cortisol and melatonin in pigs housed in constant light (LL) and constant darkness (DD). Twelve crossbred barrows, maintained under ambient photoperiod, were catheterized and tethered individually in two environmentally controlled rooms, one with LL and the other with DD. For animals in LL, fluorescent lights provided 202 +/- 15 (mean +/- standard deviation) lux of light at 65 cm above the floors. Incandescent nightlights equipped with 7 watt red bulbs provided 7 +/- 2 lux and were illuminated continuously in both rooms. Pigs were given at least 14 d exposure to LL and DD, then samples of plasma and serum were obtained at hourly intervals for 48 hr. Plasma was assayed for ACTH, and serum for cortisol and melatonin. Periodograms were constructed to analyze the data. For this type of analysis, a statistic, Qp, is calculated, and circadian periodicity is suggested if maximum Qp (Qp max) occurs at or near 24 hr. The period of the free-running rhythms (tau) at Qp max for ACTH, cortisol and melatonin for pigs in LL (23.80 +/- .01, 23.78 +/- .01, and 23.21 +/- .02 hr, respectively) did not differ significantly from those for pigs in DD (23.39 +/- .01, 23.20 +/- .01, and 22.55 +/- .02 hr, respectively).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
2.
Questionnaire‐based Analysis of Owner‐reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari‐like Malformation and Syringomyelia
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C.R. Sparks S. Cerda‐Gonzalez E.H. Griffith B.D.X. Lascelles N.J. Olby 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(1):331-339
Background
Chiari‐like malformation (CM) and syringomyelia (SM) cause a pain syndrome in Cavalier King Charles spaniels (CKCS). Clinical signs are not consistently apparent on neurologic examination, and owner reporting of signs provides vital clinical history. However, owner questionnaires for this disease are not well developed.Objectives
To develop a tool to capture owner‐reported clinical signs for use in clinical trials and to compare owner‐reported signs with the presence of pain on neurologic examination and SM on magnetic resonance imaging (MRI).Animals
Fifty client‐owned CKCS.Methods
Owners completed a questionnaire and pain/scratch map. Each dog underwent a neurologic examination and craniocervical magnetic resonance imaging (MRI). Questionnaire responses were developed into scores, area of shading for pain/scratch maps was measured, and consistency of responses between these tools was assessed. Owner‐reported findings were compared with neurologic examination findings and presence and severity of SM on MRI.Results
Thirty‐three dogs were symptomatic and 17 asymptomatic; 30 had SM. The most common sign of pain was crying out when lifted (n = 11). Extent of shaded areas on maps positively correlated with questionnaire scores for pain (r2 = 0.213, P = 0.006) and scratch (r2 = 0.104, P = 0.089). Owner‐reported findings were not significantly associated with presence or severity of SM or neurologic examination findings. Owner‐reported lateralization of signs was significantly associated with SM lateralization (P < 0.0001).Conclusions
The questionnaire and maps may be useful for clinical trials. Lack of association of owner‐reported signs with SM highlights our lack of understanding of the pathophysiology of pain in this disease. 相似文献3.
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S. T. Elazab D. E. Schrunk R. W. Griffith S. M. Ensley G. Dell'Anna K. Mullin M. G. Elsayed M. S. Amer S. M. El‐Nabtity W. H. Hsu 《Journal of veterinary pharmacology and therapeutics》2018,41(3):374-377
The pharmacokinetics of cefquinome were studied in healthy and Pasteurella multocida‐infected rabbits after a single intramuscular (IM) injection at 2 mg/kg of its sulfate salt. Twelve female New Zealand white rabbits (2.0–2.5 kg) were used; six of them served as controls, and the other six had been infected with P. multocida; the experiments were conducted 1–2 days after nasal inoculation of P. multocida when rabbits showed the signs of respiratory infection. Plasma concentrations of cefquinome were determined using high‐performance liquid chromatography. The values of elimination half‐life, area under the curve, area under the first moment curve, and mean residence time were significantly lower in infected rabbits (0.48 hr, 4.54 hr*μg/ml, 3.63 hr* hr*μg/ml and 0.8 hr, respectively) than healthy rabbits (0.72 hr, 9.11 hr*μg/ml, 9.85 hr* hr*μg/ml and 1.1 hr, respectively), whereas total body clearance was significantly higher in infected than healthy rabbits. Therefore, P. multocida infection caused significant changes in some of the pharmacokinetic parameters of cefquinome in rabbits. These pharmacokinetic changes may affect dose regimen when used in P. multocida‐infected rabbits. 相似文献
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Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations
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9.
试验结果表明 ,温室后墙悬挂反光膜进行补光后 ,对温室内测定点处最大光照度值无影响 ,但平均提高测定点处水平光照度值 15 4 8% ;温室内凌晨时气温、地温、墙温和被反光膜遮掩处墙温分别比对照温室低 1 1℃、1 5℃、0 9℃和 1 8℃ ,但正午时分别比对照温室高 1 6℃、1 4℃、0 3℃和低 11 4℃。温室经济产量增加 7 4 % ,当期经济效益增加 2 1元 /m2 。 相似文献
10.
不同栽培模式及施氮量对半旱地冬小麦氮素累积及分配的影响 总被引:6,自引:0,他引:6
【目的】研究不同栽培模式和施氮量对半旱地栽培条件下冬小麦-夏玉米轮作体系中冬小麦地上部氮素累积、分配及利用效率的影响。【方法】在陕西关中地区进行了田间试验,以常规栽培为对照,比较了补灌、覆草和垄沟等栽培模式及0,120,240 kg/hm2施氮水平,对冬小麦连续2年(2004和2005年)不同生长期各部位氮素累积量的影响。【结果】在补灌模式下,2004和2005年成熟期冬小麦叶片和茎秆的氮素累积量较其他模式低,氮素分配率也较低,而籽粒的氮素分配率较高;施用氮肥显著增加了各生长时期冬小麦叶片、茎秆、颖壳和穗轴以及籽粒的氮素累积量,当氮肥施用量由120增加到240 kg/hm2时,除籽粒外,成熟期冬小麦叶片、茎秆、颖壳和穗轴的氮素残留量均随之明显增加。与不同栽培模式相比,施用氮肥对冬小麦不同器官中氮素分配的影响较小。随着氮肥施用量的增加,氮肥利用效率、氮肥农学效率和氮肥生理效率均呈降低趋势。在不同栽培模式中,连续2年补灌栽培模式下冬小麦的氮肥利用效率、氮肥农学效率以及氮肥生理效率均较高,而其他栽培模式下这3个指标年际间的变化较大。【结论】施用氮肥可显著增加冬小麦各生长时期不同器官的氮素累积量,但对氮素在不同器官中分配比例的影响较小;与施用氮肥相比,不同栽培模式对冬小麦氮素的累积、分布无明显影响;冬季补灌有利于提高冬小麦的氮素效率。 相似文献