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Gaviraghi A. Deriu F. Soggiu A. Galli A. Bonacina C. Bonizzi L. Roncada P. 《Veterinary research communications》2010,34(1):33-42
Bovine mastitis remains the largest hazard in the global dairy industry and has facilitated the development of various therapeutic
strategies. Silver is a well-known disinfectant that is widely used in the treatment of clinical disease. In this study, we
separated bovine mammary gland epithelial cells (BMEC) using an enzyme probe. We also examined safe concentrations for the
application of silver ions in bovine mastitis, particularly in cases induced by Staphylococcus aureus. S. aureus-derived α-toxins induced cell damage through DNA fragmentation, reactive oxygen species (ROS) generation, and the dissipation
of mitochondrial transmembrane potential (MTP) in BMEC. Silver ion treatment doses of lower than 2 ppm did not induce BMEC
damage, but silver ion concentrations greater than 4 ppm was accompanied by DNA fragmentation. Furthermore, silver ions doses
below 2 ppm inhibited α-toxin-induced cell damage through the reduction of ROS generation. Recognizing this, it demonstrate
that low doses of silver ions inhibit α-toxin-induced BMEC damage and suggest that silver ions may be a potentially beneficial
treatment against bovine mastitis, particularly in cases induced by S. aureus. 相似文献
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