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MARK B. PARCHMAN DVM JAMES A. FLANDERS DVM DipiomatACVs HOLLIS N. ERB DVM PhD ROBERT WALLACE BS FRANCIS A. KALLFELZ DVM PhD 《Veterinary surgery : VS》1990,18(6):454-458
Nuclear medical bone imaging was used in combination with targeted radiography to detect metastatic or multicentric lesions in 23 dogs with skeletal neoplasms. Each dog with a radio-graphically diagnosed skeletal neoplasm was injected with Technetium-99m labeled methylene diphosphonate (99m Tc-MDP) (15.0 mCi intravenously) for whole body imaging. All areas with increased uptake of 99m Tc-MDP were radiographed. In 19 dogs, the amount of bone shaft involvement in primary sites indicated by bone imaging was larger than the amount indicated by radiography. Eighteen dogs had secondary areas of increased 99m Tc-MDP uptake, six of which had secondary areas that were suspected radiographically to be neoplastic. Four dogs had lesions characterized histologically as neoplasia, one as bone infarction and one as normal cortical bone. Positive predictive value for this strategy was 66.7%. Results of this study suggest that nuclear medical bone imaging with targeted radiography is a quick, noninvasive technique with a good positive predictive value for evaluation of the skeleton for metastatic or multicentric sites of neoplasia. 相似文献
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