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用从健康鸡消化道分离的鸡源乳酸杆菌4株,双歧杆菌2株,对引起雏鸡腹泻的鸡白痢沙门氏菌和鸡副伤寒沙门氏菌进行体外生物拮抗试验。试验结果显示:3株乳酸杆菌、2株双歧杆菌、1株芽孢杆菌对致病性沙门氏菌均有明显的生物拮抗作用(P<0.01),而1株乳酸杆菌和1株芽孢杆菌拮抗作用不明显。 相似文献
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Chungyu PAI Shunya NAKAYAMA Yasuyo ITO-FUJISHIRO Kiichi KANAYAMA Yoshiko MUNESUE Tadashi SANKAI Yasuhiro YASUTOMI Hiroshi KOIE Naohide AGEYAMA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(4):716
Nonhuman primates are commonly used as experimental animals due to their biological resemblance to humans. In patients with cardiac disease, the levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) tend to increase in response to cardiac damage, and they are thus used as indicators for the diagnosis of human heart failure. However, no reference values for ANP and BNP have been reported for heart disease in nonhuman primates. In this study, we recorded the age, sex, and body weight of 202 cynomolgus monkeys, and performed evaluations to assess the ANP and BNP levels, electrocardiography and echocardiography, and accordingly divided the monkeys into two groups: healthy monkeys and those with spontaneous cardiac disease. Statistical analysis was performed to determine the relationship of ANP and BNP with the factors of age, sex, and body weight. No significant relationship was found between the levels of ANP and BNP and the factors of age, sex, and body weight. However, both the ANP and BNP levels were significantly different between the healthy monkeys and monkeys with valvular disease. Similar to humans, the ANP and BNP levels tended to increase with the progression of cardiac disease in monkeys. Based on these results, we concluded that ANP and BNP are indicators of cardiac disease in nonhuman primates, and that this nonhuman primate cardiac disease model is applicable for cardiology research in humans. 相似文献
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