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Qi Li Makoto Osada Masaru Kashihara Ken Hirohashi and Akihiro Kijima 《Fisheries Science》2000,66(4):701-707
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Anna Kakehashi Akihiro Hagiwara Norio Imai Min Wei Shoji Fukushima Hideki Wanibuchi 《Journal of toxicologic pathology》2015,28(1):27-32
In the present study, in continuation of our previous experiment in order to investigate the mode of action (MOA) of ethyl tertiary-butyl ether (ETBE) hepatotumorigenicity in rats, we aimed to examine alterations in cell proliferation, that are induced by short-term administration of ETBE. F344 rats were administered ETBE at doses of 0, and 1,000 mg/kg body weight twice a day by gavage for 3, 10, 17 and 28 days. It was found that the previously observed significant increase of P450 total content and hydroxyl radical levels after 7 days of ETBE administration, and 8-OHdG formation at day 14, accompanied by accumulation of CYP2B1/2B2, CYP3A1/3A2, CYP2C6, CYP2E1 and CYP1A1 and downregulation of DNA oxoguanine glycosylase 1, was preceded by induction of cell proliferation at day 3. Furthermore, we observed an increase in regenerative cell proliferation as a result of ETBE treatment at day 28, followed by induction of cell cycle arrest and apoptosis by day 14. These results indicated that short-term administration of ETBE led to a significant early increase in cell proliferation activity associated with induction of oxidative stress, and to a regenerative cell proliferation as an adaptive response, which could contribute to the hepatotumorigenicity of ETBE in rats. 相似文献
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Takumi KOMIYA Akihiro MORI Naohito NISHII Hitomi ODA Eri ONOZAWA Seri SEKI Toshinori SAKO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(4):661
A 5-year-old castrated male domestic shorthair cat was diagnosed with diabetic ketoacidosis and severe insulin resistance. Although the conventional treatment for diabetic ketoacidosis was provided, the cat required frequent hospitalization because of severe dehydration and repeated diabetic ketoacidosis. We detected anti-insulin antibodies for human in this cat. Serum insulin-binding IgG levels were markedly elevated compared with those in healthy cats and other diabetic cats. We initiated prednisolone to suppress the effects of anti-insulin antibodies. After initiation of prednisolone, the cat was gradually recovered with increasing activity and appetite. Furthermore, satisfactory glycemic control was achieved with combined subcutaneous injection of insulin detemir and insulin degludec. 相似文献
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Suppressive effect of liquid potassium silicate on powdery mildew of strawberry in soil 总被引:3,自引:0,他引:3
Takeshi Kanto Akihiro Miyoshi Takuya Ogawa Kazumasa Maekawa Masataka Aino 《Journal of General Plant Pathology》2006,72(3):137-142
A soil drench of soluble silicon (liquid potassium silicate) was tested for the control of powdery mildew of strawberry in
soil for 2 years in a vinyl house under growers' conditions on two cultivars: very susceptible Toyonoka and slightly susceptible
Sachinoka. Soluble silicon suppressed the disease more effectively as a preventive control than as a control to reduce initial
incidence. The suppressive effect against this disease was more effective for Toyonoka than for Sachinoka. The control value
of soluble potassium silicate was 85.6% for Toyonoka in the first year and 60.2% in the second year, while for Sachinoka it
was 58% in the first year and 40.6% in the second year. Strawberry leaf hardness was measured for the control and silicate-treated
leaves. Although silicate-treated leaves seemed to be harder than control leaves, leaf hardness did not vary significantly
between controls and silicate-treated leaves in either of the 2 years, and the mode of preventive action of liquid potassium
silicate remains unknown. A factor other than a physical action may be involved. 相似文献
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Akihiro Okamura Hideo P. Oka Noriyuki Horie Tomoko Utoh Yoshiaki Yamada Naomi Mikawa Satoru Tanaka Katsumi Tsukamoto 《Aquaculture International》2009,17(1):91-99
For efficient production of Japanese eel Anguilla japonica eggs, knowledge of the status of the sexual maturity of potential broodstock females is important because this status directly
influences the time required to produce mature eggs by successive hormone doses. Here we apply an eye index (relative eye
size) to evaluate the gonadal status of feminized A. japonica, which were induced by administration of estradiol-17β. Examination of gonad somatic and eye indexes of 267 feminized eels,
cultivated for 12–56 months, revealed a significant correlation between these two indexes. Artificial maturation of 35 feminized
eels showed that the number of hormone injections administered before ovulation was significantly lower as the eye index score
increased, indicating availability of this noninvasive method of predicting sexual maturity of feminized eel. There was no
correlation between eye index and fertilization rate, hatching rate, or larval survival rate, suggesting that sexual maturity
before hormonal treatment does not affect egg quality. 相似文献