Antifungal activity evaluation of the constituents of Haliclona baeri and Haliclona cymaeformis, collected from the Gulf of Thailand

A new compound maleimide-5-oxime was isolated, together with 3,4-dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(−) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.     

Morphometric relationship of weight and size of cultured freshwater pearl mussel, Hyriopsis (Limnoscapha) myersiana, under laboratory conditions and earthen pond phases

The freshwater pearl mussel, Hyriopsis (Limnoscapha) myersiana (Lea, 1856), was cultured in the laboratory (0–120 days old), in an earthen pond in acrylic containers (120–270 days old) and in pocket nets with frames (270–360 days old). Measurements were taken of the length–height and the total body weight–size (shell length, shell height and shell width). It was found that the length–height in each period of culture showed a linear relationship and that the shell height increased as the shell length increased, along with the same linear relationship. When statistical analyses were performed, this linear regression line consisted of three distinct lines (P < 0.01). The general morphometric relationships between the length and height of mussels grown in the laboratory, in acrylic containers and in pocket nets were Log H = −0.147 + 0.828Log L, Log H = −0.211 + 0.909Log L and Log H = −0.264 + 0.951Log L, respectively. The relationship between the total body weight–size in different culture phases was a positive allometric equation and the two curved lines were not the same (P < 0.01). The general morphometric relationships between the length and the total body weight of the mussels cultured in acrylic containers and pocket nets were Log W = −3.747 + 2.674Log L and Log W = −4.149 + 2.976Log L, respectively. Such measurements are useful in the management of different culture phases of H. (L.) myersiana.     

Drugs and Cosmetics from the Sea

The marine environment is a rich source of both biological and chemical diversity. This diversity has been the source of unique chemical compounds with the potential for industrial development as pharmaceuticals, cosmetics, nutritional supplements, molecular probes, fine chemicals and agrochemicals. In recent years, a significant number of novel metabolites with potent pharmacological properties has been discovered from the marine organisms. Although there are only a few marine-derived products currently on the market, several robust new compounds derived from marine natural products are now in the clinical pipeline, with more clinical development. While the marine world offers an extremely rich resource for novel compounds, it also represents a great challenge that requires inputs from various scientific areas to bring the marine chemical diversity up to its therapeutic potential.