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Pilot study of the effect of acemannan in cats infected with feline immunodeficiency virus. 总被引:7,自引:0,他引:7
K M Yates L J Rosenberg C K Harris D C Bronstad G K King G A Biehle B Walker C R Ford J E Hall I R Tizard 《Veterinary immunology and immunopathology》1992,35(1-2):177-189
Acemannan, a complex carbohydrate shown to stimulate interleukin-1, tumor necrosis factor alpha and prostaglandin E2 production by macrophages, has also demonstrated antiviral activity in vitro against human immunodeficiency virus, Newcastle disease virus and influenza virus. A pilot study was undertaken to determine acemannan's effect in 49 feline immunodeficiency virus (FIV) infected cats with clinical signs of disease (Stage 3, 4 or 5), 23 of which had severe lymphopenia. Cats received acemannan either by intravenous (Group 1) or subcutaneous (Group 2) injection once weekly for 12 weeks, or by daily oral (Group 3) administration for 12 weeks. Upon entry into the study, cats were randomly assigned to one of the three groups. Laboratory analyses were performed at the beginning of the study and at Weeks 6 and 12. Cats were allowed to continue with a predetermined maintenance regimen of acemannan after completing the 12-week study. Thirteen cats died during the course of treatment. Upon necropsy, the most frequent histopathologic findings were neoplastic, kidney and pancreatic disease. Friedman's two-way ANOVA test showed no significant differences in efficacy among groups administered acemannan by the different routes. Therefore, groups were combined and a signed-ranks test was used to determine changes over time. A significant increase was seen in lymphocyte counts (P < 0.001). Neutrophil counts decreased significantly (P = 0.007), as did incidence of sepsis (P = 0.008). When cats entering with lymphopenia were analyzed separately, a much greater increase in lymphocyte counts was noted (235%) compared with non-lymphopenic cats (42%). A survival rate of 75% was found for all three groups. Thirty-six of 49 animals are alive 5-19 months post-entry. These results suggest that acemannan therapy may be of significant benefit in FIV-infected cats exhibiting clinical signs of disease. 相似文献
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Jon Ratcliff 《饲料广角》2001,(17):23-24
内部的挑战和机遇 生产和均一性 挖掘遗传的潜力,也就是繁殖性能或生长的潜力,对于动物养殖业来说是一个连续的挑战。营养通常不是限制的因素。然而,营养学家和养殖者承担这一挑战。为了最大程度地发挥动物的生产性能的潜力,高精确度的分析技术,包括DNA排列顺序,使我们能够充分了解和分析胃肠 相似文献
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Duration of maternal immunity to peste des petits ruminants 总被引:1,自引:0,他引:1
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Jon Ratcliff 《饲料广角》2001,(18):24-25
(上接第17期)
霉菌毒素的污染
饲料原料和垫草受到霉菌毒素污染的现象在亚太地区是广泛存在的(Leeson等,1995).亚太的大部分地区属于高温湿热的气候,这给霉菌的生长与繁殖以及产生霉菌毒素提供了有利的条件.由于全球极端的气候条件以及饲料原料的进口,通常没有霉菌毒素问题的国家,如澳大利亚,现在也不得不考虑预防霉菌毒素的问题.人们常常误解:"霉菌毒素是一个季节性的问题". 相似文献
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Eric Lim Teik Chung Michael Predith Frisco Nobilly Anjas Asmara Samsudin Faez Firdaus Abdullah Jesse Teck Chwen Loh 《Tropical animal health and production》2018,50(8):1727-1732
Brachiaria decumbens is an extremely productive tropical grass due to its aggressive growth habit and its adaptation to a varied range of soil types and environments. As a result of the vast availability, treated B. decumbens demonstrates as a promising local material that could be utilised as an improved diet for sheep and goats. Despite the fact that the grass significantly increases weight gains in grazing farm animals, there were many reports of general ill-thrift and sporadic outbreaks of photosensitivity in livestock due to the toxic compound of steroidal saponin found in B. decumbens. Ensiling and haymaking were found to be effective in removing toxin and undesirable compounds in the grass. Biological treatments using urea, activated charcoal, polyethylene glycol, and effective microorganisms were found to be useful in anti-nutritional factor deactivation and improving the nutritive values of feedstuffs. Besides, oral administration of phenobarbitone showed some degree of protection in sheep that fed on B. decumbens pasture. In this review, we aim to determine the effect of B. decumbens toxicity and possible treatment methods on the grass to be used as an improved diet for small ruminant. 相似文献