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Yadav Sudhir Mondal Manoranjan K. Shew Aaron Jagadish S. V. Krishna Khan Zahirul Haque Sutradhar Asish Bhandari Humnath Humphreys Elizabeth Bhattacharya Jayanta Parvin Rokhsana Rahman Mahabubur Chandna Parvesh 《Paddy and Water Environment》2020,18(2):331-343
Paddy and Water Environment - Most of the lands of the southern coastal zone of Bangladesh are protected from tidal flooding and storm surges by embankments constructed during the 1960s and 1970s,... 相似文献
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Anand K Ziebuhr J Wadhwani P Mesters JR Hilgenfeld R 《Science (New York, N.Y.)》2003,300(5626):1763-1767
A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (Mpro, also called 3CLpro), which controls the activities of the coronavirus replication complex, is an attractive target for therapy. We determined crystal structures for human coronavirus (strain 229E) Mpro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (TGEV)] Mpro, and we constructed a homology model for SARS coronavirus (SARS-CoV) Mpro. The structures reveal a remarkable degree of conservation of the substrate-binding sites, which is further supported by recombinant SARS-CoV Mpro-mediated cleavage of a TGEV Mpro substrate. Molecular modeling suggests that available rhinovirus 3Cpro inhibitors may be modified to make them useful for treating SARS. 相似文献
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