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排序方式: 共有160条查询结果,搜索用时 31 毫秒
1.
Taesik Yun Yoonhoi Koo Sanggu Kim Wonguk Lee Hakhyun Kim Dongwoo Chang Soochong Kim Mhan-Pyo Yang Byeong-Teck Kang 《The Veterinary quarterly》2021,41(1):163
An 8-year-old neutered male Yorkshire Terrier dog presented with head pressing, vestibular ataxia, neck tenderness, and no oculocephalic reflex. A demarcated lesion in the pons was identified on MRI. The patient was tentatively diagnosed with a glioma and was treated with hydroxyurea plus imatinib and prednisolone. After 30 days of therapeutic treatment, the patient showed a clear improvement in neurological signs, which lasted for 1117 days. On day 569 after the initiation of treatment, 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) was performed with no significant findings on visual analysis. The average and maximal standardized uptake values (SUVs) were 1.92 and 2.29, respectively. The tumor-to-normal-tissue (T/N) ratio was 0.97. The first evidence of clinical deterioration was noticed on day 1147. On day 1155, 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (18F-FDOPA)-PET was performed. High uptake of 18F-FDOPA was observed in the intracranial lesion. The mean and maximal SUVs of the tumor were 1.59 and 2.29, respectively. The T/N ratio was 2.22. The patient was euthanized on day 1155 and histopathologic evaluations confirmed glioma (astrocytoma). This case shows that chemotherapy with hydroxyurea plus imatinib may be considered in the treatment of canine glioma. Furthermore, this is the first case describing the application of 18F-FDG and 18F-FDOPA in a dog with glioma. 相似文献
2.
Pharmacokinetic study of meropenem in healthy beagle dogs receiving intermittent hemodialysis 下载免费PDF全文
S. Y. Byun J. W. Jeong J. H. Choi K. P. Lee H. Y. Youn H. J. Maeng K. H. Song T. S. Koo K. W. Seo 《Journal of veterinary pharmacology and therapeutics》2016,39(6):560-565
Meropenem, a second carbapenem antimicrobial agent with a broad spectrum of activity, is used to treat sepsis and resistant‐bacterial infections in veterinary medicine. The objective of this study was to identify the pharmacokinetics of meropenem in dogs receiving intermittent hemodialysis (IHD) and to determine the proper dosing in renal failure patients receiving IHD. Five healthy beagle dogs were given a single i.v. dose of 24 mg/kg of meropenem and received IHD. The blood flow rate, dialysate flow, and ultrafiltration rate were maintained at 40 mL/min, 300 mL/min, and 40 mL/h, respectively. Blood samples were collected for 24 h from the jugular vein and from the extracorporeal arterial and venous line. Urine samples and dialysate were also collected. The concentrations of meropenem were assayed using HPLC/MS/MS determination. The peak plasma concentration was 116 ± 37 μg/mL at 15 min. The systemic clearance was 347 ± 117 mL/h/kg, and the steady‐state volume of distribution was 223 ± 67 mL/kg. Dialysis clearance was 71.1 ± 34.3 mL/h/kg, and the extraction ratio by hemodialysis was 0.455 ± 0.150. The half‐life (T1/2) in dogs with IHD decreased compared with those without IHD, and the reduction in T1/2 was greater in renal failure patients than in normal patients. Sixty‐nine percent and 21% of the administered drug were recovered by urine and dialysate in the unchanged form, respectively. In conclusion, additional dosing of 24 mg/kg of meropenem after dialysis could be necessary according to the residual renal function of the patient based on the simulated data. 相似文献
3.
Spyra Marcin Kleemann Janina Cetin Nuket Ipek Vázquez Navarrete Cesar Jesús Albert Christian Palacios-Agundez Igone Ametzaga-Arregi Ibone La Rosa Daniele Rozas-Vásquez Daniel Adem Esmail Blal Picchi Paolo Geneletti Davide König Hannes J. Koo HongMi Kopperoinen Leena Fürst Christine 《Landscape Ecology》2019,34(7):1715-1735
Landscape Ecology - Several case studies investigated the role of ecosystem services in participatory planning processes. However, no systematic study exists that cuts across a large number of... 相似文献
4.
N.J. Cave S.T. Koo 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2015,29(3):781-785
Background
Electrochemical approach to the assessment of acid‐base states should provide a better mechanistic explanation of the metabolic component than methods that consider only pH and carbon dioxide.Hypothesis/Objectives
Simplified strong ion equation (SSIE), using published dog‐specific values, would predict the measured serum pH of diseased dogs.Animals
Ten dogs, hospitalized for various reasons.Methods
Prospective study of a convenience sample of a consecutive series of dogs admitted to the Massey University Veterinary Teaching Hospital (MUVTH), from which serum biochemistry and blood gas analyses were performed at the same time. Serum pH was calculated using the SSIE, and published values for the concentration and dissociation constant for the nonvolatile weak acids (Atot and K a), and subsequently was compared with the dog''s actual pH . To determine the source of discordance between and , the calculations were repeated using a series of substituted values for Atot and K a.Results
The did not approximate the for any dog (P = 0.499, r 2 = 0.068), and was consistently more basic. Substituted values Atot and K a did not significantly improve the accuracy (r 2 = 0.169 to <0.001). Substituting the effective SID produced a strong association between and (r 2 = 0.977).Conclusions and clinical importance
Using the simplified strong ion equation and the published values for Atot and K a does not appear to provide a quantitative explanation for the acid‐base status of dogs. Efficacy of substituting the effective SID in the simplified strong ion equation suggests the error lies in calculating the SID. 相似文献5.
Thimothe J Bonsi IA Padilla-Zakour OI Koo H 《Journal of agricultural and food chemistry》2007,55(25):10200-10207
Grapes are rich sources of potentially bioactive polyphenols. However, the phenolic content is variable depending on grape variety, and may be modified during vinification. In this study, we examined the chemical composition and biological activity of phenolic extracts prepared from several red wine grape varieties and their fermented byproduct of winemaking (pomace) on some of the virulence properties of Streptococcus mutans a well-known dental pathogen. Grape phenolic extracts were obtained from Vitis vinifera varieties Cabernet Franc and Pinot Noir and Vitis interspecific hybrid varieties Baco Noir and Noiret. The anthocyanins and flavan-3-ols content were highly variable depending on grape variety and type of extract (whole fruit vs fermented pomace). Nevertheless, all grape phenolic extracts remarkably inhibited glucosyltransferases B and C (70-85% inhibition) at concentrations as low as 62.5 microg/mL (P < 0.01). Furthermore, the glycolytic pH-drop by S. mutans cells was inhibited by the grape extracts without affecting the bacterial viability; an effect that can be attributed to partial inhibition of F-ATPase activity (30-65% inhibition at 125 microg/mL; P < 0.01). The biological activity of fermented pomace was either as effective as or significantly better than whole fruit grape extracts. The results showed that grape phenolic extracts, especially from pomace, are highly effective against specific virulence traits of S. mutans despite major differences in their phenolic content. 相似文献
6.
7.
Ji Hyeon Ahn Joon Ha Park In Hye Kim Jae-Chul Lee Bing Chun Yan Min Sik Yong Choong Hyun Lee Jung Hoon Choi Ki-Yeon Yoo In Koo Hwang Seung Myung Moon Hyung-Cheul Shin Moo-Ho Won 《Journal of veterinary science (Suw?n-si, Korea)》2014,15(3):335-342
Melatonin affects diverse physiological functions through its receptor and plays an important role in the central nervous system. In the present study, we compared immunoreactivity patterns of arylalkylamine N-acetyltransferase (AANAT), an enzyme essential for melatonin synthesis, and melatonin receptor type 1B (MT2) in the spinal cord of young adult (2~3 years) and aged (10~12 years) beagle dogs using immunohistochemistry and Western blotting. AANAT-specific immunoreactivity was observed in the nuclei of spinal neurons, and was significantly increased in aged dog spinal neurons compared to young adult spinal neurons. MT2-specific immunoreactivity was found in the cytoplasm of spinal neurons, and was predominantly increased in the margin of the neuron cytoplasm in aged spinal cord compared to that in the young adult dogs. These increased levels of AANAT and MT2 immunoreactivity in aged spinal cord might be a feature of normal aging and associated with a feedback mechanism that compensates for decreased production of melatonin during aging. 相似文献
8.
Dae Young Yoo Woosuk Kim Dae Won Kim Sung Min Nam Hyo Young Jung Jong Whi Kim Choong Hyun Lee Jung Hoon Choi Moo-Ho Won Yeo Sung Yoon In Koo Hwang 《Journal of veterinary science (Suw?n-si, Korea)》2014,15(1):27-33
In this study, we determined how rosiglitazone (RSG) differentially affected hippocampal neurogenesis in mice fed a low-fat diet (LFD) or high-fat diet (HFD; 60% fat). LFD and HFD were given to the mice for 8 weeks. Four weeks after initiating the LFD and HFD feeding, vehicle or RSG was administered orally once a day to both groups of mice. We measured cell proliferation and neuroblast differentiation in the subgranular zone of the dentate gyrus using Ki67 and doublecortin (DCX), respectively, as markers. In addition, we monitored the effects of RSG on the levels of DCX and brain-derived neurotrophic factor (BDNF) in hippocampal homogenates. At 8 weeks after the LFD feeding, the numbers of Ki67- and DCX-positive cells as well as hippocampal levels of DCX and BDNF were significantly decreased in the RSG-treated group compared to the vehicle-treated animals. In contrast, the numbers of Ki67- and DCX-positive cells along with hippocampal levels of DCX and BDNF in the HFD fed mice were significantly increased in the RSG-treated mice compared to the vehicle-treated group. Our data demonstrate that RSG can modulate the levels of BDNF, which could play a pivotal role in cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus. 相似文献
9.
Jung-Hoon Jee Ja-Geun Koo Yoo-Hwa Keum Joon-Suk Kang Kwan H A Park & Ju-Chan Kang 《Aquaculture Research》2007,38(1):26-35
This study investigated the effects of different types of diet and sediment on the growth parameters of juvenile tiger crab Orithyia sinica under laboratory conditions, focusing on survival, growth and moulting. In the first set of experiments, juvenile tiger crabs were reared with five different types of sediment, i.e., soft sand, coarse sand, soft sand mixed with coarse sand, mud or bare bottom. Soft sand resulted in not only the highest survival rate of 78% but also the best rate of growth and feed intake. Crabs reared with a mud substrate showed the worst results in these parameters. The intermoult period, however, was not affected by sediment types. In the second set of experiments, crabs were fed different types of diet to determine their effects on the same growth parameters. Diets were composed of different combinations with Manila clam (Ruditapes philippinarum), brine shrimp (Artemia nauplii), microencapsulated feeds and marine diatom (Chaetoceros gracilis). Survival and growth in crabs fed Manila clam as a diet component were significantly higher than in those on other diets. The highest survival and growth were achieved with a diet that included all four components. These results provide valuable information on the appropriate bottom substrates and diet types necessary for artificial mass culture of the tiger crab. 相似文献
10.
This study evaluated the potential application of an atmospheric plasma (AP) treatment as a pre-treatment for digital textile printing (DTP) of polyester (PET) fabrics and cotton, in order to determine its viability as an alternative to the usual chemical treatment. The surface properties of the AP-treated fabrics were examined through scanning electron microscopy (SEM) and contact angle, and the physical properties, such as electrostatic voltage and water absorbance, were tested. The properties of cotton and PET with the AP treatment were found to be dependent on number of repetitions and electric voltage. Although no remarkable surface differences were observed by SEM in the fabrics before and after treatment, the static contact angle of the PET after AP treatment was decreased from 85 ° to 24 ° at wave. In addition, the charge decay time decreased as the voltage and number of treatments increased. The absorption height of PET changed after exposure to 7 mm with increasing measurement time. The K/S with and without the AP pre-treated and DTP finished cotton was better than that with the usual chemical modification. In PET, the 0.5 kW and 1 time AP-treated specimen showed the highest K/S values. 相似文献