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Konstantinos Axarlis Maria G. Daskalaki Sofia Michailidou Nikolais Androulaki Antiopi Tsoureki Evangelia Mouchtaropoulou Ourania Kolliniati Ioanna Lapi Eirini Dermitzaki Maria Venihaki Katerina Kousoulaki Anagnostis Argiriou Zouhir El Marsni Christos Tsatsanis 《Marine drugs》2021,19(5)
Metabolic syndrome-related diseases affect millions of people worldwide. It is well established that changes in nutritional habits and lifestyle can improve or prevent metabolic-related pathologies such as type-2 diabetes and obesity. Previous reports have shown that nutritional supplements have the capacity to limit glucose intolerance and suppress diabetes development. In this study, we investigated the effect of dietary supplementation with fish-derived extracts on obesity and type 2 diabetes and their impact on gut microbial composition. We showed that nutritional supplements containing Fish Complex (FC), Fish Complex combined with Cod Powder (FC + CP), or Cod Powder combined with Collagen (CP + C) improved glucose intolerance, independent of abdominal fat accumulation, in a mouse model of diet-induced obesity and type 2 diabetes. In addition, collagen-containing supplements distinctly modulate the gut microbiome in high-fat induced obesity in mice. Our results suggest that fish-derived supplements suppress diet-induced type 2 diabetes, which may be partly mediated through changes in the gut microbiome. Thus, fish-derived supplements and particularly the ones containing fish collagen have potential beneficial properties as dietary supplements in managing type 2 diabetes and metabolic syndrome via modulation of the gut microbiome. 相似文献
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Athanasios I. Papadopoulos Aristotelis Anagnostis Despina Lazarou 《Pesticide biochemistry and physiology》2005,82(2):115-124
In the present study, we report on the changes observed in the kinetic properties of pyruvate kinase (PK) from whole body homogenate in the three developmental stages of the insect Tenebrio molitor after insecticide or acetone injection, and after injury and 24 h starvation. The apparent Km value of the enzyme towards phosphoenolpyruvate was higher in the pupae stage than in the rest developmental stages although the same enzyme type appears to be present throughout the life span of the insect as judged by its Vmax and sensitivity towards ATP and Alanine. The highest specific activity, twice as high as that of larvae and pupae, was observed in adults. Starvation resulted to activation of the enzyme by increasing the Km value in the two feeding stages, namely larvae and adult, while injury had the opposite effect. Acetone injection did not have any significant effect at any stage. Insecticide injection had varying effects, depending upon the developmental stage, the dose and the type of the insecticide. In larvae, low doses of methyl paraoxon and methyl parathion activated the enzyme but as the dose increased the Km value returned to normal levels. Low dose of decamethrin activated the enzyme also but at high dose it caused a severe inactivation as judged by a fivefold increase of the observed Km. In pupae, decamethrin had no effect, methyl parathion had similar effects to those observed in larvae, and methyl paraoxon caused activation of the enzyme at any dose given. In the adult stage none of the injected insecticides had any effect on the Km value although Vmax and specific activity were significantly altered. 相似文献
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Georgios Tsiotas Athanassios A. Argiriou 《Journal of Agricultural, Biological & Environmental Statistics》2011,16(3):371-388
A statistically efficient approach is adopted for modeling spatial time-series of large data sets. The estimation of the main
diagnostic tool such as the likelihood function in Gaussian spatiotemporal models is a cumbersome task when using extended
spatial time-series such as air pollution. Here, using the Innovation Algorithm, we manage to compute it for many spatiotemporal
specifications. These specifications refer to the spatial periodic-trend, the spatial autoregressive moving average, the spatial
autoregressive integrated and fractionally integrated moving average Gaussian models. Our method is applied to daily pollutants
over a large metropolitan area like Athens. In the applied part of our paper, we first diagnose temporal and spatial structures
of data using non-likelihood based criteria, such as the empirical autocorrelation and covariance functions. Second, we use
likelihood and non-likelihood based criteria to select a spatiotemporal model among various specifications. Finally, using
kriging we regionalize the resulting parameter estimates of the best-fitted model in space at any unmonitored location in
the Athens region. The results show that a specific autoregressive integrated moving average spatiotemporal model can optimally
perform in within and out of spatial sample estimation. Supplemental materials for this article are available from the journal
website. 相似文献
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Avian β-defensins (AvβDs) are antimicrobial peptides that play significant roles in the innate immune system in chickens. The aim of this study was to identify the types of AvβDs expressed in the chicken ovary, to investigate the effects of sexual maturation in the ovarian mRNA abundance and to determine the changes in their expression levels as a result to Salmonella enteritidis (SE) infection. RNA was extracted from the ovary of healthy prepubertal, sexually mature and aged birds, as well as from sexually mature and aged SE infected birds. Real-time PCR analysis revealed that 11 AvβDs genes were expressed in the chicken ovary. A significant up regulation of AvβD1, 3, 4, 5, 7 and 11 was observed in the ovary of sexually mature and aged birds. Furthermore, a significant up-regulation of AvβD4, 5, 7, 11 and 12 was observed in the ovary of SE infected sexually mature birds. These results suggest that the mRNA expression of at least six AvβDs increase with age in the ovary of laying hens, and that at least five AvβDs show an induction in their expression in response to SE infection, indicating an AvβD-mediated immune response mechanism in the chicken ovary. 相似文献
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I.V Ganopoulos A. Argiriou 《The Journal of Horticultural Science and Biotechnology》2013,88(5):444-448
SummarySweet cherry is self-incompatible due to having a gametophytic self-incompatibility system. S alleles in the style and pollen determine possible crossing relationships. Knowledge of the S allele constitution of cultivars is important for sweet cherry growers and breeders. Recently, molecular methods have been developed to distinguish between S alleles in sweet cherry.The S allele genotypes of 21 sweet cherry cultivars widely grown in Greece, including 19 not previously genotyped, were determined based on their S-RNase gene sequences using PCR analysis. Eight different S alleles in ten combinations were distinguished and two new S-genotypes (S1S13 and S4S30) were documented. Four alleles, S1, S3, S4, and S9 were widespread and together were responsible for 85% of the S-haplotypes. Therefore many of the cultivar combinations were semi-compatible. In Greece, semi-compatibility was shown to correlate with low yields. However, the cultivar ‘Hybrid Tragana Edessis x Unknown’ (S3S13) and the cultivar ‘Kapsiotika’ (S2S5) carry rare S-haplotypes and are therefore fully cross-compatible with most of the cultivars analysed. 相似文献
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