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Kanako Muta Takako Miyabe‐Nishiwaki Kenichi Masui Isao Yajima Tomoya Iizuka Akihisa Kaneko Ryohei Nishimura 《Journal of veterinary pharmacology and therapeutics》2021,44(1):18-27
The objectives of this study were (a) to establish a population pharmacokinetic model and (b) to investigate the clinical and physiological effects of a single bolus dose of propofol in common marmosets. In Study 1, pharmacokinetic analysis was performed in six marmosets under sevoflurane anaesthesia. 8 mg/kg of propofol was administrated at a rate of 4 mg kg?1 min?1. Blood samples were collected 2, 5, 15, 30, 60, 90, 120 or 180 min after starting propofol administration. Plasma concentration was measured, and population pharmacokinetic modelling was performed. A two‐compartment model was selected as the final model. The population pharmacokinetic parameters were as follows: V1 = 1.14 L, V2 = 77.6 L, CL1 = 0.00182 L/min, CL2 = 0.0461 L/min. In Study 2, clinical and physiological parameters were assessed and recorded every 2 min after 12 mg/kg of propofol was administrated at a rate of 4 mg kg?1 min?1. Immobilization was sustained for 5 min following propofol administration without apparent bradycardia. While combination of propofol and sevoflurane caused apnoea in Study 1, apnoea was not observed following single administration of propofol in Study 2. These data provide bases for further investigation on intravenous anaesthesia using propofol in common marmosets. 相似文献
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Eiji Hayashi Kazuya Iizuka Shin-ichi Sukeno Kohzo Kohno 《Journal of Forest Research》1998,3(2):119-122
We determined the survival rate of tree families produced by the intra- and interspecific crossing of larch species damaged
by browsing of vole (Clethrionomys rufocanus bedfordiae Thomas) and the contents of ether extracts (EE) in their bark. The average survival ofLarix gmelini var.japonica Pilg. (L. gmelini)×L. gmelini (G×G) was highest, followed by the hybridL. gmelini×L. leptolepis Gordon (G×L). The families of the hybrid G×L, which is considered suitable for silviculture in Hokkaido, Japan, showed significant
differences in survival rates, suggesting that it is possible to produce improved varieties of the hybrid which are more resistant
to vole browsing. The EE contents of the bark were under strong hereditary control, and the rank of the EE content among the
various families hardly fluctuated between the location of the test fields. The correlation coefficient between the survival
rates and the EE contents was highly significant (r=0.89,n=24,p<0.01), indicating that the EE content in the bark may be used as a possible index of resistance or susceptibility to vole
browsing in larch plantations.
A part of this report was presented at the 106th Annual Meeting of the Japanese Forestry Society, at Sapporo, April, 1995. 相似文献
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Kazuya Iizuka Narumi Toya Jyunichi Ohshima Futoshi Ishiguri Naoko Miyamoto Mineaki Aizawa Tatsuhiro Ohkubo Chisato Takenaka Shinso Yokota 《Journal of Wood Science》2018,64(1):59-64
To utilize forest resources in areas affected by fallout from the Fukushima Daiichi Nuclear Power Plant accident, it is important to understand the mechanisms of 137Cs movement through the stem wood of contaminated trees. Understanding the mechanism of absorption and migration of 137Cs to stem wood is necessary for clues to the future prediction of the transition of 137Cs to xylem. In the present study, radial variations in 137Cs concentration were investigated in Japanese cedar (Cryptomeria japonica D. Don) trees collected 1 year and 10 months after the accident. Additionally, the relationship between 137Cs concentration and potassium (K) content was established. Trees with a higher moisture content and lower lightness value in heartwood tended to have a higher 137Cs concentration in the heartwood. In these trees, 137Cs concentration peaked at the heartwood–sapwood boundary and gradually decreased toward the pith. By contrast, K content within the heartwood remained nearly constant along the radial direction. The heartwood-to-sapwood ratio of 137Cs concentration was significantly positively correlated with that of K content. Based on these results, we suggest that 137Cs movement from sapwood to heartwood might be related to the K content ratio of heartwood and sapwood. 相似文献
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Denny Irawati Yuya Takashima Chisato Ueda J. P. Gentur Sutapa Sri Nugroho Marsoem Futoshi Ishiguri Kazuya Iizuka Nobuo Yoshizawa Shinso Yokota 《Journal of Wood Science》2013,59(6):522-527
We examined the enzymatic saccharification and ethanol fermentation of the spent media (SMs) from Auricularia polytricha cultivation using wood meals of Falcataria moluccana, Shorea sp., and Tectona grandis. Although the hydrolysis weight decrease and reducing sugar yield were higher in SM of F. moluccana, the ethanol yield was higher in SM of Shorea sp. Ozone treatment of SM further increased the hydrolysis weight decrease, reducing sugar, and ethanol yields in Shorea sp. These results indicate that SM of A. polytricha is a suitable biomass material to produce fermentable sugars for ethanol production, and that ozone treatment is a suitable method for increasing the ethanol yield. 相似文献
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T Yamaguchi T Nagatsu T Sugimoto S Matsuura T Kondo R Iizuka H Narabayashi 《Science (New York, N.Y.)》1983,219(4580):75-77
After administration of tyrosine, total concentration of biopterin, the cofactor for tyrosine hydroxylase, was increased in the striatum, adrenal glands, and serum of rats, and in the serum of humans. Serum biopterin is lower in patients with Parkinson's disease than in normal controls. After oral administration of tyrosine, the increase in serum biopterin concentration was smaller in patients with Parkinson's disease (less than twofold) than in healthy controls (three-to sevenfold). These results suggest that tyrosine may have a regulatory role in biopterin biosynthesis and that patients with Parkinson's disease may have some abnormality in the regulation of biopterin biosynthesis. 相似文献
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Jun Tanabe Akira Tamura Jyunichi Ohshima Kazuya Iizuka Shinso Yokota 《Scandinavian Journal of Forest Research》2017,32(1):39-44
With emphasis on tree breeding for wood quality in Picea jezoensis, we aimed to evaluate radial and between-family variations in the microfibril angle (MFA) of the S2 layer in the latewood tracheids in 10 open-pollinated families of 43-year-old P. jezoensis trees. In addition, the relationships between MFA/wood density with the modulus of elasticity (MOE) or modulus of rupture (MOR) were investigated. Significant differences in MFA between families were found from the pith toward the bark. MFA showed higher values around the pith area, although some families showed relatively lower values than others around this area. In addition, due to a larger coefficient of variations of MFA near the pith, the potential for juvenile wood MFA improvement may be greater compared with mature wood. MOE was correlated with MFA in juvenile wood and with wood density in mature wood, whereas MOR was mainly correlated with wood density at radial positions in both woods. Therefore, to improve the MOE and MOR of P. jezoensis wood, both MFA and wood density would be factors to consider in both juvenile and mature woods. On the other hand, there are indications that, only wood density would be an important criterion for improving mature wood properties. 相似文献
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Fuminori Tanihara Maki Hirata Satoru Iizuka Shinya Sairiki Masahiro Nii Nhien Thi Nguyen Quynh Anh Le Takayuki Hirano Takeshige Otoi 《Animal Science Journal》2019,90(6):712-718
The aim of this study was to investigate the ovarian follicular development, developmental competence of oocytes, and plasma anti‐Müllerian hormone (AMH) levels of Japanese wild boar crossbred (wild hybrid) gilts, whose litter size is inferior to that of European breeds. Ovary and plasma samples were collected from two different breeds of gilts (wild hybrid and Large White breeds). The ovaries from the wild hybrid gilts had a lower average numbers of secondary follicles and vesicular follicles in ovarian cross‐sections and of good quality oocytes collected from ovarian follicles as compared with those from Large White gilts (p < 0.05). The development rate to the blastocyst stage of good quality oocytes after in vitro maturation, fertilization and culture was also lower (p < 0.05) in wild hybrid gilts than in Large White gilts. Plasma AMH levels with >0.16 ng/ml were detected in 8.3% of the examined wild hybrid gilts and 33% of the Large White gilts. These results indicate that the low reproductive performance of wild hybrid breed may result in part from low numbers of vesicular follicles and good quality oocytes, and low developmental competence of oocytes. Moreover, plasma AMH levels may support low number of vesicular follicles in ovaries of wild hybrid gilts. 相似文献
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Tomomi Kaku Kei’ichi Baba Toru Taniguchi Manabu Kurita Ken-ichi Konagaya Katsuaki Ishii Teiji Kondo Satoshi Serada Haruka Iizuka Rumi Kaida Teruaki Taji Yoichi Sakata Takahisa Hayashi 《Journal of Wood Science》2012,58(4):281-289
The transgenic expression of Aspergillus xyloglucanase cDNA (AaXEG2) with 35S promoter in the leaves of open field-grown poplars was studied. The level of xyloglucan in the transgenic poplars was decreased to 15–16% in the non-fertile soil (forest-field soil) and to 21–22% in the fertile soil (farming-field soil) compared with that of the wild-type poplars. The leaves exhibited a smaller surface area with more rounded teeth than those of the wild-type plants, similar to the sun leaf variety that was grown in the incubation room and subsequently greenhoused. The majority of total veins with water-conducting vascular bundles were shorter in the leaves of the transgenic poplars than those of the wild type. This decrease in vein length may result from a decrease in xyloglucan during leaf development, from which large numbers of proteins were markedly downregulated in the leaves of the transgenic plants via proteomic analysis. It seems likely that the leaves of the transgenic poplars came to relax the edges of their tooth rather than extend their veins as a result of the loosening of the xyloglucan cellulose networks in the leaves. 相似文献