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排序方式: 共有117条查询结果,搜索用时 15 毫秒
1.
Domain separation in the activation of glycogen phosphorylase a 总被引:3,自引:0,他引:3
E J Goldsmith S R Sprang R Hamlin N H Xuong R J Fletterick 《Science (New York, N.Y.)》1989,245(4917):528-532
The crystal structure of glycogen phosphorylase a complexed with its substrates, orthophosphate and maltopentaose, has been determined and refined at a resolution of 2.8 angstroms. With oligosaccaride bound at the glycogen storage site, the phosphate ion binds at the catalytic site and causes the regulatory and catalytic domains to separate with the loss of stabilizing interactions between them. Homotropic cooperativity between the active sites of the allosteric dimer results from rearrangements in isologous contacts between symmetry-related helices in the subunit interface. The conformational changes in the core of the interface are correlated with those observed on covalent activation by phosphorylation at Ser14 (phosphorylase b----a). 相似文献
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Experimental infection of normal and immunosuppressed pigs with Pseudomonas pseudomallei 总被引:1,自引:0,他引:1
AD THOMAS JC FORBES-FAULKNER TL D''ARCY JH NORTON D HOFFMANN 《Australian veterinary journal》1990,67(2):43-46
A single dose of 5 x 10(8) bacilli of Pseudomonas pseudomallei by intratracheal injection resulted in acute (21 cases) or chronic (19 cases) melioidosis in 40 of 48 pigs. Fifteen (10 acute and 5 chronic) had been immunosuppressed by cyclophosphamide before inoculation. The major clinical signs were initial fever, marked neutrophilia and, in the acute cases, respiratory distress. There were no signs of the nasal and ocular discharge, paresis or diarrhoea seen in acute cases in south-east Asia. The cyclophosphamide treatment caused a significant decrease in the neutrophil count by 7 d after inoculation in all 15 immunosuppressed pigs, and all were culture positive at necropsy. Eight of the 33 non-treated pigs were culture negative at necropsy. Pigs overcoming the initial phase of infection had more abscess-like nodules that were bacteriologically sterile at necropsy than the pigs with acute cases of melioidosis. P. pseudomallei was isolated predominantly from the spleen, lungs and the injection site. Although only one strain was used in this study, it is likely that Australian strains of P. pseudomallei are not as virulent as the south-east Asian isolates. 相似文献
4.
F.B. Goldsmith 《Biological conservation》1974,6(2):79-83
In spite of increasing numbers of tourists each year, Majorca retains a variety of natural and semi-natural vegetation types. These are principally in the limestone sierra and around the coast. Of the fairly numerous species of endemic plants which occur, some are frequent. The Balearic Islands are also an important staging-post for migrant birds, and the wetlands of Majorca are the most valuable habitat from the ornithological standpoint. This paper summarizes the major vegetation types of Majorca and discusses the contribution made to the conservation value of the island by its 21 species of vascular plants that are recognized as endemic to the Balearic Islands and in 13 cases are exclusively Mallorcan. Finally, the conservation threats arising from urbanization, from indirect effects of development, and from changes in agricultural practice, are briefly discussed. 相似文献
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Adenosine monophosphate is required for the activation of glycogen phosphorylase b and for release of the inhibition of phosphorylase a by glucose. Two molecules of adenosine monophosphate (AMP) bind to symmetry related sites at the subunit interface of the phosphorylase dimer. Adenosine triphosphate (ATP) binds to the same site, but does not promote catalytic activity. The structure of glucose-inhibited phosphorylase a bound to AMP and also of the complex formed with glucose and ATP is described. Crystallographic refinement of these complexes reveals that structural changes are associated with AMP but not ATP binding. The origin of these effects can be traced to different effector binding modes exhibited by AMP and ATP, respectively. The conformational changes associated with AMP binding traverse multiple paths in the enzyme and link the effector and catalytic sites. 相似文献
7.
Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate 总被引:12,自引:0,他引:12
S R Sprang S G Withers E J Goldsmith R J Fletterick N B Madsen 《Science (New York, N.Y.)》1991,254(5036):1367-1371
8.
Microspectrophotometry of photoreceptor organelles from eyes of the prawn Palaemonetes 总被引:3,自引:0,他引:3
Microspectrophotometric measurements of individual dark-adapted rhabdoms of the prawn Palaemonetes vulgaris reveal the presence of two light-sensitive pigments. A pigment with maximum absorbancy at 555 nanometers is converted by light to a long-lived intermediate with wavelength of maximum absorbancy at 496 nanometers. A second pigment with wavelength of maximum absorbancy at 496 nanometers bleaches in the light, seemingly without forming detectable products at wavelengths longer than 375 nanometers. Both pigments occur in each layer of microvilli. 相似文献
9.
Carbon monoxide and human health 总被引:10,自引:0,他引:10
10.
Respiratory exposure to lead: epidemiological and experimental dose-response relationships 总被引:2,自引:0,他引:2
Epidemiologic studies of blood lead levels in general and occupational groups show a logarithmic regression on estimated atmospheric exposure. Experimental results at the same and higher levels show a dose-response relationship which fits the same regression. The data imply that long-term increases in atmospheric lead will result in predictably higher blood lead levels in the exposed populations. 相似文献