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Henrik Harms Barbora Orlikova Seungwon Ji Damun Nesaei-Mosaferan Gabriele M. K?nig Marc Diederich 《Marine drugs》2015,13(8):4949-4966
The Ascomycota Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. A new gliotoxin derivative, 6-acetylmonodethiogliotoxin (1) was obtained from fungal extracts. Compounds 2 and 3, methylthio-gliotoxin derivatives were formerly only known as semi-synthetic compounds and are here described as natural products. Additionally the polyketide heveadride (4) was isolated. Compounds 1, 2 and 4 dose-dependently down-regulated TNFα-induced NF-κB activity in human chronic myeloid leukemia cells with IC50s of 38.5 ± 1.2 µM, 65.7 ± 2.0 µM and 82.7 ± 11.3 µM, respectively. The molecular mechanism was studied with the most potent compound 1 and results indicate downstream inhibitory effects targeting binding of NF-κB to DNA. Compound 1 thus demonstrates potential of epimonothiodiketopiperazine-derived compounds for the development of NF-κB inhibitors. 相似文献
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The availability of macroscopic quantities of fullerenes has resulted in a vast number of physical and chemical studies of these new materials. However, the mechanisms that lead to the formation of these spherical carbon allotropes are not well understood. Mass spectral evidence has been obtained for the size-selective growth of fullerenes through the coalescence of cyclo[n] carbons, molecular carbon allotropes consisting of monocyclic rings with n carbon atoms. Whereas coalescence of cyclo[30]carbon (cyclo-C(30)) produces predominantly buckminsterfullerene (C(60)), the smaller rings cyclo-C(l8) and cyclo-C(24) preferentially produce fullerene C(70) through distinct intermediates. The present studies not only provide new insights into fullerene formation mechanisms but also raise the possibility of tailoring the size distributions of fullerenes by variation of the appropriate properties of the precursors. 相似文献
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Diederich F Whetten RL Thilgen C Ettl R Chao I Alvarez MM 《Science (New York, N.Y.)》1991,254(5039):1768-1770
Early reports on the formation of the higher fullerenes C(76), C(78), C(84), C(90), and C(94) by resistive heating of graphite stimulated theoretical calculations of possible cage structures for these all-carbon molecules. Among the five fullerene structures with isolated pentagons found for C(78), a closed-shell D3h-isomer was predicted to form preferentially. Two distinct C(78)-isomers were formed in a ratio of approximately 5:1 and could be separated by high-performance liquid chromatography. The carbon-13 nuclear magnetic resonance (NMR) spectrum of the major isomer is uniquely consistent with a C2v-structure. The NMR data also support a chiral D(3)-structure for the minor isomer. The isolation of specifically these two isomers of C(78) provides insight into the stability of higher fullerene structures and into the mechanism for fullerene formation in general. 相似文献
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Diane Lefebvre Eric Depiereux Jean-Marie Giffroy Claire Diederich 《Journal of Veterinary Behavior: Clinical Applications and Research》2010,5(1):2-6
We quantified the behavioral perturbation induced in kenneled dogs using a classical procedure of video equipment installation. Using 14-minute sessions of videorecording, 136 hours of recordings were collected from 14 healthy, individually housed Malinois shepherds. Our results show that dogs trotted, jumped, and ran more during the first 2 minutes of recording. These behaviors suggest an intense but brief agitation following installation of the video equipment. These results lead us to advise researchers, when studying the behavior of kenneled dogs by videotaping, to evaluate the duration of perturbations stemming from their particular experimental procedure and to carefully examine it. 相似文献
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Cline Moriou Damien Lacroix Sylvain Petek Amr El-Demerdash Rozenn Trepos Tinihauarii Mareva Leu Cristina Florean Marc Diederich Claire Hellio Ccile Debitus Ali Al-Mourabit 《Marine drugs》2021,19(3)
Chemical investigation of the South-Pacific marine sponge Suberea clavata led to the isolation of eight new bromotyrosine metabolites named subereins 1–8 (2–9) along with twelve known co-isolated congeners. The detailed configuration determination of the first representative major compound of this family 11-epi-fistularin-3 (11R,17S) (1) is described. Their chemical characterization was achieved by HRMS and integrated 1D and 2D NMR (nuclear magnetic resonance) spectroscopic studies and extensive comparison with literature data. For the first time, a complete assignment of the absolute configurations for stereogenic centers C-11/17 of the known members (11R,17S) 11-epi-fistularin-3 (1) and 17-deoxyfistularin-3 (10) was determined by a combination of chemical modifications, Mosher’s technology, and ECD spectroscopy. Consequently, the absolute configurations of all our new isolated compounds 2–9 were determined by the combination of NMR, Mosher’s method, ECD comparison, and chemical modifications. Interestingly, compounds 2–7 were obtained by chemical transformation of the major compound 11-epi-fistularin-3 (1). Evaluation for acetylcholinesterase inhibition (AChE), DNA methyltransferase 1 (DNMT1) modulating activity and antifouling activities using marine bacterial strains are also presented. 相似文献
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Snyder EJ Anderson MS Tong WM Williams RS Anz SJ Alvarez MM Rubin Y Diederich FN Whetten RL 《Science (New York, N.Y.)》1991,253(5016):171-173
Atomic force microscopy and x-ray diffractometry were used to study 1500 A-thick films of pure C(60) grown by sublimation in ultrahigh vacuum onto a CaF(2) (111) substrate. Topographs of the films did not reveal the expected close-packed structures, but they showed instead large regions that correspond to a face-centered cubic (311) surface and distortions of this surface. The open (311) structure may have a relatively low free energy because the low packing density contributes to a high entropy of the exposed surface. 相似文献
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