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排序方式: 共有247条查询结果,搜索用时 31 毫秒
1.
Hiraoka H Hisasue M Nagashima N Miyama T Tanimoto T Watanabe M Itamoto K Mizuno T Inokuma H Okuda M 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2007,69(6):665-668
An eleven-year-old female pug was referred to Yamaguchi University Animal Hospital for evaluation of anemia and thrombocytopenia. The cytological examination of the peripheral blood showed some giant monocytic lineage blast cells. A few granulocytes and platelets had dysplastic features. On day 7, in addition to increasing the monocytic lineage cells, the dysplastic features of the blood had also increased compared to the initial examination. We performed bone marrow aspiration upon her death. The bone marrow revealed dysplastic features in all three hematopoietic cell lines, and an increase in the monocytic cell line. Based on the features of the bone marrow and the peripheral blood, this case was confirmed to be myelodysplastic syndrome--Chronic myelomonocytic leukaemia (MDS-CMML). 相似文献
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Kazuhiro Shiozaki Momo Shiozaki Junko Masuda Akiko Yamauchi Shuichi Ohwada Toshiki Nakano Toshiyasu Yamaguchi Tadao Saito Koji Muramoto Minoru Sato 《Fisheries Science》2010,76(5):865-872
Angiotensin-I-converting enzyme (ACE) plays a crucial role in the crisis of hypertension. Some peptides that originate from
protease hydrolysates are known to suppress ACE activity in vitro and in vivo. Here, we investigated whether trypsin hydrolysate
of oyster Crassostrea gigas showed hypotensive activity and ACE inhibition. The hydrolysate significantly suppressed systolic blood pressure and ACE
activity in spontaneously hypertensive rats following a one-shot oral administration and a long-term feeding experiment lasting
9 weeks. Each hydrolysate from oyster tissue showed ACE inhibitory activity, indicating the hypotensive effect was due to
synergism. One potent ACE inhibitory peptide, Asp-Leu-Thr-Asp-Tyr, was identified from the hydrolysate of the striate muscle,
and the peptide exhibited hypotensive activity in vivo. Protease digestion analysis suggested that Asp-Tyr could be the real
effector of this penta-peptide in vivo. 相似文献
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K Yamashita T Fujinaga M Okumura M Takiguchi N Tsunoda S Mizuno 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1991,53(6):1019-1024
The serum concentration of C-reactive protein (CRP) in horses was measured by single radial immunodiffusion (SRID) using rabbit anti-equine CRP serum to evaluate the significance of CRP as an acute-phase reactive protein. In serum samples of clinically normal newborn thoroughbred foals before being given colostrum, serum CRP was not detectable (less than or equal to 1 microgram/ml). The serum CRP concentration was found to increase quickly and reach a peak level of approximately 14.1 micrograms/ml in 12-month-old horses. Then, it decreased gradually to reach a low value of 5.4 micrograms/ml in the 4-year-old. In horses over 5-year-old, serum CRP concentration was stable at values of 7 to 8 micrograms/ml. In mares during the peri-natal period, serum CRP concentration decreased at 2 months before delivery, showed moderate changes just before and after delivery, and then increased to relatively high level by 2 months after delivery. The concentration of serum CRP was found to be increased at 24 hours after experimentally inflammatory stimuli in adult horses, and reached peak values of 3 to 6 times as high as the base line values at 3 to 5 days. Serum CRP concentration returned to base line values by 2 to 3 weeks after treatments. It is clear from these data that CRP is one of the acute-phase reactive proteins in horses. 相似文献
6.
Okabayashi K Kano R Sirouzu K Yanai T Mizuno M Yamamura H Saegusa S Hasegawa A 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2003,65(8):953-955
Two feline cases were diagnosed as systemic cryptococcosis due to Cryptococcus neoformans (teleomorph: Filobasidiella neoformans) by PCR assay with CAP59 gene primers using urine, serum and biopsy samples. The results of molecular analysis were consistent with the mycological findings. 相似文献
7.
Lens formation in the absence of optic cup in rat embryos irradiated with soft X-ray 总被引:1,自引:0,他引:1
In order to investigate the effect of soft X-ray irradiation on ocular development, pregnant rats were exposed to a single 12.5 Gy irradiation on embryonic day 9 (ED 9). The embryos obtained by laparotomy on ED 12 and 21 were examined for ocular abnormalities under a binocular stereo-microscope and a light microscope. The ED 12 embryos were stained with osmium tetroxide to facilitate the observation. The stereo-microscopic examination on ED 12 and 21 revealed various types of ocular abnormalities characterized primarily by aplasia or hypoplasia of the optic cup and invaginated lens placode. The light microscopic examination further confirmed these findings histomorphologically, and the hypoplastic abnormalities were classified into three types: (1) hypoplasia of the optic cup and invaginated lens placode, (2) complete malformation of the optic cup and hypoplasia of the invaginated lens placode, and (3) complete malformation of the optic cup and invaginated lens placode. Because the lens was formed in the complete absence of the retina, the development and differentiation of the retina and lens do not seem to be tightly synchronized. Thus, this sequential analysis on ocular abnormalities during the early stage of development supports the notion that the presence of the retina is not always necessary for the development of the lens. 相似文献
8.
Mizuno AW Ohtaishi N 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2002,64(2):137-144
Cranial features (development, individual variation, and sexual dimorphism) were examined from the 23 metrical characters and 2 nonmetrical characters (the degree of closure of the 9 cranial sutures and the presence of sagittal crest) in the two spotted seal specimen groups at the Nemuro Strait, Hokkaido. One specimen group was incidentally taken in the salmon trap nets between 1982 and 1983 (n = 70), and the other was randomly sampled by damage control kill between 1997 and 1998 (n = 82). The development of morphometrical characters of skulls ceased at 5.6, 10.7, 7.9, and 11.9 yr. old, for 1982-83 male, 1982-83 female, 1997-98 male and 1997-98 female, respectively. The sutures were half ankylosed till approximately 10 yr. old in both sexes. The sagittal crest began from about 5 yr. old in male. Individual variation of skull was large in the feeding, breathing, and facial-expression apparatus. On the other hand, the variation of braincase, and skull concerning to the movement of head/neck tended to be small. Only 1997-98 specimens exhibited a sexual dimorphism in skull characters except for the braincase, whereas the dimorphism was not found in 1982-83 specimens. We could not detect the significant difference between two specimen groups, although there were a few differences in characters related to the rostrum and mandible. 相似文献
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Therapeutic soft contact lenses (TSCL) were applied to a thoroughbred racehorse with corneal ulcer refractory to topical medication. The insertion of the TSCL was conducted on day 36 using a nose twitch under sedation, auriculopalpebral nerve block, and topical anesthesia. The lens was retained, with the duration of wear lasting 114 days. Ocular pain improved immediately and fluorescein tests were negative 17 days after insertion. The horse was able to undergo training and ran in two races while wearing the TSCL. Thus a TSCL was found to be clinically useful for treating corneal ulcers in racehorses. 相似文献