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排序方式: 共有1039条查询结果,搜索用时 15 毫秒
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Rebecca Windsor Samuel Stewart Jessica Schmidt Mario Mosqueda Ignazio Piras Stefan M. Keller Briana Steinmetz Dori L. Borjesson Matthew Huentelman Chand Khanna 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2022,36(4):1382
BackgroundNecrotizing meningoencephalitis (NME) in the pug dogs is a fatal neuroinflammatory disease associated with rapid progression and poor response to conventional immunosuppressive therapy. Diagnosis is typically made after severe neurological abnormalities have manifested.Hypothesis/ObjectivePug dogs at genetic risk for NME might manifest neurological abnormalities before developing pathognomonic clinical signs of NME.AnimalsThirty‐six pug dogs less than 4 years of age asymptomatic for NME.MethodsProspective observational cohort study with germline genome‐wide genotyping. Neurological examinations were performed 4 weeks apart to document reproducible findings of central nervous system disease. Magnetic resonance imaging, cerebrospinal fluid analysis, and testing for infectious diseases were performed in all pugs with reproducible abnormalities detected on neurological examination.ResultsThe overall risk allele frequency in this cohort was 40%; 5 (14%) dogs were high risk, 19 (53%) dogs were medium risk, and 12 (33%) dogs were low genetic risk for NME. Reproducible abnormalities detected on neurological examination were identified in 8/24 (33%) genetically at‐risk dogs and 0/12 (0%) low risk dogs. Clinical abnormalities included multifocal spinal pain in 8/8, reduced menace response in 5/8, and lateralizing postural reaction deficits in 5/8 pugs. There was a strong association between genotype risk and the presence of this clinical phenotype (P = .03).Conclusions and Clinical ImportanceOur findings suggest the presence of a novel early clinical phenotype of NME in apparently asymptomatic genetically at‐risk pugs which might be used to plan early diagnostic and therapeutic clinical trials. 相似文献
3.
The dinoflagellate Prorocentrum cordatum, often called P. minimum, is a potentially toxic alga found in algal blooms. Volatile compounds released by the alga might carry important information, e.g., on its physiological state, and may act as chemical messengers. We report here the identification of volatile organic compounds emitted by two strains, xenic P. cordatum CCMP 1529 and axenic P. cordatum CCMP 1329. The volatiles released during culture were identified despite their low production rates, using sensitive methods such as open-system-stripping analysis (OSSA) on Tenax TA desorption tubes, thermodesorption, cryofocusing and GC/MS-analysis. The analyses revealed 16 compounds released from the xenic strain and 52 compounds from the axenic strain. The majority of compounds were apocarotenoids, aromatic compounds and small oxylipins, but new natural products such as 3,7-dimethyl-4-octanolide were also identified and synthesized. The large difference of compound composition between xenic and axenic algae will be discussed. 相似文献
4.
Rates of carbon dioxide production of cocoons, juveniles and matures of Lumbricus rubellus were measured at five constant (2°C, 5°C, 10°C, 15°C, 20°C) and three diurnally fluctuating temperature regimes (0–10°C, 5–15°C, 10–20°C) covering the whole range of temperature conditions experienced by this species in forests in Central Germany. Respiration rates of developmental stages significantly increased with temperature both under constant and fluctuating regimes. Overall, at constant temperature regimes Q10 values for cocoons, juvenile and mature earthworms were 1.6, 2.7 and 2.0, respectively. At fluctuating temperature regimes Q10 values were generally higher with 2.4, 3.6 and 3.5 for cocoons, juvenile and mature earthworms, respectively. At the same mean temperature respiration rates at fluctuating regimes exceeded those at constant regimes in all developmental stages. 相似文献
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Greiner M Müller-Graf C Hiller P Schrader C Gervelmeyer A Ellerbroek L Appel B 《Berliner und Münchener tier?rztliche Wochenschrift》2007,120(3-4):98-107
According to current scientific opinion the risk of human infection with H5N1 via preparation and consumption of poultry meat is negligible.This opinion has not yet been challenged by a formal risk assessment, due to the lack of empirical data. We have developed a scenario pathway model as a conceptual framework for a formal assessment of the H5N1 risk to humans through consumption of poultry meat and parameterise the model using information derived from expert opinions. The aim of this study was to investigate whether the notion of an overall negligible risk via the oral infection route is consistent with ad hoc data and expert opinions on the relevant parameters of the model.The model is mainly based on expert opinion. A stochastic Monte-Carlo simulation was conducted which took into consideration (amongst others) the exposure and infection of chicken (broiler and layer), turkeys, ducks and geese, the probabilities of detection prior to slaughter, virus survival and contamination during slaughter, as well as during the cutting and preparation of meat in commercial plants and in private households, respectively. The empirical consumption pattern for poultry meat in Germany was taken into account in the simulation.The results show that the risk for the individual consumer is practically zero whereas up to 23 cases per year in Germany might occur if the upper (more pessimistic) ranges of the expert opinions apply.The finding of a low but non-negligible risk to the population is discussed in relation to the epidemiological information available from recent outbreaks in South East Asia. 相似文献
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The conversion of anthropogenic into more natural, self-regenerating forests is one of the major objectives of forestry throughout
Europe. In this study, we present investigations on permanent plots with different silvicultural treatment in NE German pine
stands. Management of old-growth pine stands on acidic and nutrient-poor sandy sites differs in fencing, thinning, and planting
of certain tree species. The investigations were carried out on the community, population, and individual level of the pine
forest ecosystems. Thus, vegetation changes, size and height of tree populations, and height increment of tree individuals
were observed over a time span of 6 years. Special attention was paid to short-lived tree species such as, e.g., Frangula alnus and Sorbus aucuparia, as well as to Fagus sylvatica as one of the most typical forest tree species of Central Europe. Vegetation changes are interpreted as a consequence of
natural regeneration of formerly degraded forest sites, involving an increase in nutrient availability. High browsing pressure
can be considered as a key factor for the inhibition of tree seedlings and growth of saplings. Some Sorbus aucuparia individuals, however, succeeded in growing out of the browsing height also in unfenced stands. Few found specimens of Fagus sylvatica proved that this species is able to establish spontaneously on these relatively dry, acidic sites under continental climate
influence. Such natural regeneration processes, also including spontaneous rejuvenation of trees, can be integrated into silviculture
as passive forest conversion management. An active management like thinning of stands, planting of trees, and fencing can
accelerate forest conversion with regard to height growth and species number of trees. 相似文献
9.
Review of ground-based methods to measure the distribution of biomass in forest canopies 总被引:1,自引:0,他引:1
Dominik Seidel Stefan Fleck Christoph Leuschner Tom Hammett 《Annals of Forest Science》2011,68(2):225-244
? Context
Ecological research and an effective forest management need accurate information on the structure of the forest canopy to understand the biochemical, physiological and biogeochemical processes within a forest.? Research question
This paper reviews the currently available instruments for measuring the distribution of biomass within forest canopies. We compare the most well-established approaches and present the different measurable parameters. A special focus lies on the resolution of the obtained data.? Results
It was found that only 3D laser scanners offer data with the resolution required by ecologists, private landholders, the forest industry and the public to detect trends in tree growth patterns and canopy interactions in all three spatial dimensions. But data validation, data analysis and parameter extraction are still under development, and the price of the instrument is quite high.? Conclusion
Research should focus on the parameter extraction from terrestrial laser scanner data as this could allow the calculation of functional attributes for different sections of a canopy on a high spatial resolution. It could also help ecologists characterize the structure of forest stands in a quick and precise way. 相似文献10.
Stefan Fleck Nathalie Cools Bruno De Vos Henning Meesenburg Richard Fischer 《Annals of Forest Science》2016,73(4):945-957