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Einbond LS Soffritti M Esposti DD Wu HA Tibaldi E Lauriola M He K Park T Su T Huggins L Wang X Roller M Brennan R 《Fitoterapia》2012,83(3):461-468
Background
Studies indicate that extracts and purified components from black cohosh inhibit the growth of human breast cancer cells, but the molecular targets and signaling pathways have not yet been defined.Purpose
This study examines the pharmacological mechanisms and toxicological effects in the short term of the herb black cohosh on female Sprague–Dawley rats.Materials and methods
To assess effects on gene activity and lipid content, we treated female Sprague–Dawley rats with an extract of black cohosh enriched in triterpene glycosides (27%) at 35.7 or 0 mg/kg. Four animals for each group were sacrificed at 1, 6 and 24 h after treatment; liver tissue and serum samples were obtained for gene expression and lipid analysis.Results
Microarray analysis of rat liver tissue indicated that black cohosh markedly downregulated mitochondrial oxidative phosphorylation genes. Phospholipid biosynthesis and remodeling, PI3-Kinase and sphingosine signaling were upregulated, driven largely by an upregulation of several isoforms of phospholipase C. Hierarchical clustering indicated that black cohosh clustered with antiproliferative compounds, specifically tubulin binding vinca alkaloids and DNA alkylators. In support of this, black cohosh repressed the expression of cyclin D1 and ID3, and inhibited the proliferation of HepG2, p53 positive, liver cancer cells. Black cohosh reduced the level of free fatty acids at 6 and 24 h and triglycerides at 6 h in the serum, but increased the free fatty acid and triglyceride content of the treated livers at 24 h.Conclusion
Our results suggest that black cohosh warrants further study for breast cancer prevention and therapy. 相似文献2.
Stagnati Lorenzo Busconi Matteo Soffritti Giovanna Martino Michelangelo Lanubile Alessandra Marocco Adriano 《Genetic Resources and Crop Evolution》2021,68(7):2931-2942
Genetic Resources and Crop Evolution - Sorghum [Sorghum bicolor (L.) Moench] is a subsistence crop and the main food for populations in arid or semiarid regions and it is appreciated for the... 相似文献
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Stagnati L. Martino M. Soffritti G. Lanubile A. Ravasio A. Marocco A. Rossi G. Busconi M. 《Genetic Resources and Crop Evolution》2021,68(7):3025-3038
Genetic Resources and Crop Evolution - Beaked corn represents one of the most characteristics and neglected group of Italian maize landraces. These genotypes, classified in the... 相似文献
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