AIM: To assess the benefit of inducing emesis in dogs that have ingested rodenticide bait containing brodifacoum (BDF), by determining the amount of BDF in bait recovered from the vomitus relative to the estimated amount consumed.
METHODS: Between 2014 and 2015 samples of vomitus from seven dogs that ingested rodenticide baits containing BDF were submitted by veterinarians in New Zealand. All seven dogs had been given apomorphine by the veterinarian and vomited within 1 hour of ingesting the bait. Some or all of the bait particles were retrieved from each sample and were analysed for concentrations of BDF using HPLC. Based on estimations of the mass of bait consumed, the concentration of BDF stated on the product label, and the estimated mass of bait in the vomitus of each dog, the amount of BDF in the vomited bait was calculated as a percentage of the amount ingested.
RESULTS: For five dogs an estimation of the mass of bait ingested was provided by the submitting veterinarian. For these dogs the estimated percentage of BDF in the bait retrieved from the vomitus was between 10–77%. All dogs were well after discharge but only one dog returned for further testing. This dog had a normal prothrombin time 3 days after ingestion.
CONCLUSIONS AND CLINICAL RELEVANCE: The induction of emesis within 1 hour of ingestion can be a useful tool in reducing the exposure of dogs to a toxic dose of BDF. The BDF was not fully absorbed within 1 hour of ingestion suggesting that the early induction of emesis can remove bait containing BDF before it can be fully absorbed. 相似文献
A series of abortions occurred in mares in New South Wales during 2004 that involved similar and unusual findings on post mortem examination of aborted fetuses and fetal membranes. The term Equine Amnionitis and Fetal Loss (EAFL) was developed to describe the condition. This form of abortion had not been previously recognised in Australia. The pathology alone is not specific for EAFL and diagnosis requires demonstration of a combination of certain pathological and bacteriological features. The purpose of this paper is to describe patterns considered consistent with EAFL cases as a working case definition for use by veterinarians and veterinary pathologists in identifying future cases of EAFL. More detailed papers are in preparation to fully describe the epidemiological, histopathological, and microbiological aspects of EAFL. 相似文献
Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial deformation of the active site that prevents nicotinamide adenine dinucleotide (NAD) binding. An ABAD peptide specifically inhibits ABAD-Abeta interaction and suppresses Abeta-induced apoptosis and free-radical generation in neurons. Transgenic mice overexpressing ABAD in an Abeta-rich environment manifest exaggerated neuronal oxidative stress and impaired memory. These data suggest that the ABAD-Abeta interaction may be a therapeutic target in AD. 相似文献
Elevated phosphate concentrations at Safaga and Quseir, Red Sea, Egyptian coast, wererelated to some ecological and nutritional aspects of the macro-alga Cystoseira myrica during1985. The results obtained were compared with those recorded for a non-polluted control site atGhardaqa. Chemical analysis of surface seawater samples revealed that the concentrations of dissolvedphosphate at Safaga and Quseir were 3 and 20 times as much as that at Ghardaqa, respectively.The standing crop of C. myrica showed two peaks in spring and autumn. Maximum biomass yield(491 g m-2) and number of individuals (127 m-2) of C. myrica were recorded in the spring at theGhardaqa site. Quseir C. myrica samples contained significantly higher protein-N, total-N andtotal-P values but lower carbohydrate values than the Safaga and Ghardaqa samples (LSD at 1%level). Tissue N:P molar ratios for C. myrica, Laurencia papillosa and Ulva lactuca collected fromGhardaqa ranged from 68-98, compared to 30-59 for the same species collected at thephosphorus polluted sites at Safaga and Quseir. The carbon levels and the C:N ratios of C. myricaexhibited no significant variations in the three studied sites. However, the C:P ratios of Ghardaqaplants were significantly higher than those of Safaga and Quseir. 相似文献