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Nguyen Vu SON James Kenn CHAMBERS Makoto NAKATA Yasutsugu MIWA Hiroyuki NAKAYAMA Kazuyuki UCHIDA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2022,84(2):208
This report described the histopathological and immunohistochemical features of cutaneous mast cell tumor (MCT) in six hedgehogs. The hedgehogs presented single cutaneous mass with ulcer and crusting. Histologically, the neoplastic lesions were characterized by the proliferation of well-differentiated mast cells (3 cases), and atypical mast cells (3 cases) with one atypical histiocytic morphology. Immunohistochemically, tumor cells were positive for KIT and mast cell tryptase, and were negative for Iba-1. In well-differentiated MCT, all patients were clinically improved and survived more than 365 days after surgical excision, whereas an atypical histiocytic MCT showed aggressive behavior with re-recurrence, and the animal died 115 days after surgery. These findings suggest that, compatible with other animals, well-differentiated MCT has a better prognosis in hedgehogs. 相似文献
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Kei IMURA James Kenn CHAMBERS Kazuyuki UCHIDA Shunsuke NOMURA Satoshi SUZUKI Hiroyuki NAKAYAMA Yasutsugu MIWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(12):1667-1670
An 8-month-old common marmoset
(Callithrix jacchus) was presented with tic-like symptoms, and a
2-year-old pigmy marmoset (Callithrix pygmaea) was presented with dyspnea
and hypersalivation. Both monkeys died within a few days, and necropsies were performed.
Histopathological examinations revealed ulcerative stomatitis with epithelial cell
swelling and eosinophilic intranuclear inclusion bodies in the oral epithelium of both
cases. In the central and peripheral nervous systems, neuronal cell degeneration with
intranuclear inclusion bodies was observed. Immunohistochemical examination using
anti-herpes simplex virus type 1 antibody revealed virus antigens in both cases. Both
animals had been kept as pets with limited exposure to the ambient environment except via
their owners. Therefore, herpes simplex virus type-1 was probably acquired from close
contact with their owners. 相似文献
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Tews I Findeisen F Sinning I Schultz A Schultz JE Linder JU 《Science (New York, N.Y.)》2005,308(5724):1020-1023
Class III adenylyl cyclases contain catalytic and regulatory domains, yet structural insight into their interactions is missing. We show that the mycobacterial adenylyl cyclase Rv1264 is rendered a pH sensor by its N-terminal domain. In the structure of the inhibited state, catalytic and regulatory domains share a large interface involving catalytic residues. In the structure of the active state, the two catalytic domains rotate by 55 degrees to form two catalytic sites at their interface. Two alpha helices serve as molecular switches. Mutagenesis is consistent with a regulatory role of the structural transition, and we suggest that the transition is regulated by pH. 相似文献
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Hideyuki KANEMOTO Rei MORIKAWA James Kenn CHAMBERS Koichi KASAHARA Yasuko HANAFUSA Kazuyuki UCHIDA Koichi OHNO Hiroyuki NAKAYAMA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(6):715-719
A Pomeranian dog, 1 year- and 8 month-old neutered female, was presented with persistent
respiratory distress and recurrent generalized demodicosis. Physical examination revealed
cyanosis, rough respiratory sounds, multifocal alopecia and dermal erosions on the dorsal
side of the forelimbs, perineal area and skin around the eyes. A severe diffuse
interstitial lung pattern was observed on thoracic radiographs. The blood examination
revealed neutrophilia and hypoglobulinemia. Serum immunoglobulin concentrations of IgG and
IgA were low. Histopathological examination revealed severe diffuse interstitial pneumonia
with Pneumocystis carinii infection. Severe lymphoid depletion was
observed in the spleen and other organs with lymphoid follicles consisted mainly of
CD3-positive T cells and few cells of B-cell lineage. B-cell hypoplasia with subsequent
antibody deficiency was suspected. 相似文献
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Naoki HIROSE Kazuyuki UCHIDA Satoru MATSUNAGA James Kenn CHAMBERS Hiroyuki NAKAYAMA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(2):255-259
Choroid plexus tumor (CPT) is a primary intracranial neoplasm of the choroid plexus epithelium in the central nervous system. In the current World Health Organization classification, CPT is classified into two categories; choroid plexus papilloma (CPP) and carcinoma (CPC). In the present study, we investigated immunohistochemical expressions of N-cadherin, E-cadherin and β-catenin in 5 canine CPT cases (1 disseminated CPC, 2 CPCs and 2 CPPs). One CPP case was positive for N-cadherin and β-catenin, but negative for E-cadherin. The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin. The other cases were positive for the three molecules examined. These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells. 相似文献
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Background
In Southern Africa savannas climate change has been proposed to alter rainfall, the most important environmental driver for woody plants. Woody plants are a major component of savanna vegetation determining rangeland condition and biodiversity. In this study we use a spatially explicit, stochastic computer model to assess the impact of climate change on the population dynamics of Grewia flava, a common, fleshy-fruited shrub species in the southern Kalahari. Understanding the population dynamics of Grewia flava is a crucial task, because it is widely involved in the shrub/bush encroachment process, a major concern for rangeland management due to its adverse effect on livestock carrying capacity and biodiversity.Results
For our study we consider four climate change scenarios that have been proposed for the southern Kalahari for the coming decades: (1) an increase in annual precipitation by 30–40%, (2) a decrease by 5–15%, (3) an increase in variation of extreme rainfall years by 10–20%, (4) and increase in temporal auto-correlation, i.e. increasing length and variation of periodic rainfall oscillations related to El Niño/La Niña phenomena. We evaluate the slope z of the time-shrub density relationship to quantify the population trend. For each climate change scenario we then compared the departure of z from typical stable population dynamics under current climatic conditions. Based on the simulation experiments we observed a positive population trend for scenario (1) and a negative trend for scenario (2). In terms of the projected rates of precipitation change for scenario (3) and (4) population dynamics were found to be relatively stable. However, for a larger increase in inter-annual variation or in temporal auto-correlation of rainfall population trends were negative, because favorable rainfall years had a limited positive impact due to the limited shrub carrying capacity.Conclusions
We conclude that a possible increase in precipitation will strongly facilitate shrub encroachment threatening savanna rangeland conditions and regional biodiversity. Furthermore, the negative effects found for positive auto-correlated rainfall support current ecological theory stating that periodically fluctuating environments can reduce population viability because species suffer disproportionately from poor environmental conditions. 相似文献10.
Rhulani Makhuvele Kenn Foubert Nina Hermans Luc Pieters Luc Verschaeve Esam Elgorashi 《The Onderstepoort journal of veterinary research》2022,89(1)
Aflatoxins are potent hepatotoxic and carcinogenic secondary metabolites produced by toxigenic fungi. The present study investigated the protective effect of methanolic leaf extracts of Monanthotaxis caffra (MLEMC) against aflatoxin B1-induced toxicity in male Sprague-Dawley rats. The rats were randomly divided into 6 groups of 8 animals each. Five groups were administered orally for seven days with three different concentrations of MLEMC (100 mg/kg, 200 mg/kg and 300 mg/kg), curcumin (10 mg/kg) or vehicle (25% propylene glycol). The following day, these groups were administered 1 mg/kg b.w. of aflatoxin B1 (AFB1). The experiment was terminated three days after administration of AFB1. Group 6 represented untreated healthy control. Serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, creatinine and liver histopathology were evaluated. Methanolic leaf extracts of M. caffra decreased the levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase and creatinine in the sera of rats as compared with the AFB1 intoxicated group. Co-administration of MLEMC improved the histological characteristics of the hepatocytes in contrast to the AFB1 treated group, which had mild to severe hepatocellular injuries including bile duct proliferation, bile duct hyperplasia, lymphoplasmacytic infiltrate and fibrosis. Extracts of M. caffra were beneficial in mitigating the hepatotoxic effects of AFB1 in rats by reducing the levels of liver enzymes and preventing hepatic injury. 相似文献