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Hellal F Hurtado A Ruschel J Flynn KC Laskowski CJ Umlauf M Kapitein LC Strikis D Lemmon V Bixby J Hoogenraad CC Bradke F 《Science (New York, N.Y.)》2011,331(6019):928-931
Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-β signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow. 相似文献
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Thouin Hugues Le Guédard Marina Hellal Jennifer Joulian Catherine Charron Mickael Devau Nicolas Battaglia-Brunet Fabienne 《Journal of Soils and Sediments》2022,22(9):2422-2434
Journal of Soils and Sediments - Arsenic (As) is one of the most widespread toxic elements, affecting human health through consumption of contaminated water or food. This work studied the effects... 相似文献
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