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Utiyama M. Fukuyama T. Yamagata S. Ohta S. Izumi K. Harimaya T. Fujiyoshi Y. Yamada T. Inage M. 《Water, air, and soil pollution》2001,130(1-4):325-330
Water, Air, &; Soil Pollution - Removal of sulfur dioxide through the absorption into cloud droplets is the initial stage of acid rain formation. We studied this process by forming an artificial... 相似文献
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Receptor assay-guided isolation of anti-GABAergic insecticidal alkaloids from a fungal culture 总被引:2,自引:0,他引:2
Kuriyama T Kakemoto E Takahashi N Imamura K Oyama K Suzuki E Harimaya K Yaguchi T Ozoe Y 《Journal of agricultural and food chemistry》2004,52(12):3884-3887
The gamma-aminobutyric acid (GABA) receptor bears sites of action for insecticides. To discover GABA receptor-directed insecticides in natural products, fungal culture extracts were screened for their ability to inhibit specific binding of the radiolabeled noncompetitive antagonist [3H]1-(4-ethynylphenyl)-4-n-propyl-2,6,7-trioxabicyclo[2.2.2]octane to housefly head membranes. The screening efforts led to the isolation of two alkaloids from Aspergillus terreus: PF1198A (alantrypinone) and PF1198B (serantrypinone), which had IC50 values of 0.34 and 2.1 microM, respectively, in this assay. These compounds were ca. 47-61-fold selective for housefly vs rat GABA receptors. Both compounds showed insecticidal activity against Myzus persicae in the range of 100-500 ppm. Binding assay-guided screening should provide significant opportunities for the identification of novel and selective insecticides. 相似文献
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