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Gingerich PD 《Science (New York, N.Y.)》1984,226(4677):994-996
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Diagnosis of myeloid leukosis induced by a recombinant avian leukosis virus in commercial white leghorn egg laying flocks 总被引:4,自引:0,他引:4
Commercial white leghorn egg layer flocks being used to produce fertile eggs for human vaccine production exhibited dramatically low peaks in egg production, two to four times higher than normal weekly mortality, and high numbers of cull, nonlaying birds after the onset of sexual maturity. These lower production characteristics could not be associated with management-related problems. Gross lesions of cull and fresh dead birds necropsied showed approximately 60% lacked ovarian activity and had lesions of a bacterial bursitis or synovitis, whereas the other 40% had tumors of the viscera but not of the bursa of Fabricius. Histologic examination of tumor-containing tissues showed lesions typical of myelocytomatosis. The diagnosis of myeloid leukosis was confirmed by the isolation of a recombinant avian leukosis virus (ALV) containing the LTR of subgroup J and the envelope of subgroup B ALV. A positive polymerase chain reaction with primers specific for the 3' untranslated region LTR confirmed the presence of LTR of ALV-J. The source of infection with this recombinant ALV was not determined; however, it is likely that commingling of the day-old egg-type chicks with ALV-J-infected meat-type chicks in a common hatchery had contributed to this outbreak. 相似文献
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G F Hoffsis D A Gingerich D M Sherman R R Bruner 《Journal of the American Veterinary Medical Association》1977,171(1):67-70
Total intravenous feeding was accomplished for 5 clinically normal calves and for 1 calf with atresia coli. During the trials, which lasted 8 to 14 days (mean of 12 days), calves were not permitted to ingest any food or water. Body weight and state of hydration remained essentially constant. Plasma protein content decreased, but there were only minor changes in other physiologic measures. Calves were clinically normal at the conclusion of the trials. 相似文献
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Gingerich PD 《Science (New York, N.Y.)》1983,222(4620):159-161
Rates of morphological evolution documented in laboratory selection experiments, historical colonization events, and the fossil record are inversely related to the interval of time over which they are measured. This inverse relationship is an artifact of comparing a narrow range of morphological variation over a wide range of time intervals, and it is also a product of time averaging. Rates measured over different intervals of time must be scaled against interval length before they can be compared. 相似文献
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Brown PG Hildebrand AR Zolensky ME Grady M Clayton RN Mayeda TK Tagliaferri E Spalding R MacRae ND Hoffman EL Mittlefehldt DW Wacker JF Bird JA Campbell MD Carpenter R Gingerich H Glatiotis M Greiner E Mazur MJ McCausland PJ Plotkin H Rubak Mazur T 《Science (New York, N.Y.)》2000,290(5490):320-325
The preatmospheric mass of the Tagish Lake meteoroid was about 200,000 kilograms. Its calculated orbit indicates affinity to the Apollo asteroids with a semimajor axis in the middle of the asteroid belt, consistent with a linkage to low-albedo C, D, and P type asteroids. The mineralogy, oxygen isotope, and bulk chemical composition of recovered samples of the Tagish Lake meteorite are intermediate between CM and CI meteorites. These data suggest that the Tagish Lake meteorite may be one of the most primitive solar system materials yet studied. 相似文献
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A preliminary evaluation of efficacy and minimum toxic concentration of AQUI-STM, a fish anaesthetic/sedative, was determined in two size classes of six species of fish important to US public aquaculture (bluegill, channel catfish, lake trout, rainbow trout, walleye and yellow perch). In addition, efficacy and minimum toxic concentration were determined in juvenile–young adult (fish aged 1 year or older) rainbow trout acclimated to water at 7°C, 12°C and 17°C. Testing concentrations were based on determinations made with range-finding studies for both efficacy and minimum toxic concentration. Most of the tested juvenile–young adult fish species were induced in 3 min or less at a nominal AQUI-STM concentration of 20 mg L–1. In juvenile–young adult fish, the minimum toxic concentration was at least 2.5 times the selected efficacious concentration. Three out of five species of fry–fingerlings (1.25–12.5 cm in length and < 1 year old) were induced in ≤ 4.1 min at a nominal concentration of 20 mg L–1 AQUI-STM, with the other two species requiring nominal concentrations of 25 and 35 mg L–1 for similar times of induction. Recovery times were ≤ 7.3 min for all species in the two size classes. In fry–fingerlings, the minimum toxic concentration was at least 1.4 times the selected efficacious concentration. There appeared to be little relationship between size of fish and concentrations or times to induction, recovery times and minimum toxic concentration. The times required for induction and for recovery were increased in rainbow trout as the acclimation temperature was reduced. 相似文献
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