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Asubiojo O. I. Aina P. O. Oluwole A. F. Arshed W. Akanle O. A. Spyrou N. M. 《Water, air, and soil pollution》1991,(1):819-828
The effects of cement production on the elemental composition of soils in the neighborhood of two cement factories in Nigeria have been investigated using the XRF and PIXE/RBS techniques. The concentration of 21 elements viz:-Mg, Al, Si, P, S, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Sr, Pb, As, Zr, Rb and Br, were determined in about 30 samples. Calcium, P, S, Cr, Ni, Cu and Zn, were found to be relatively enriched in the soils of the cement factory premises. Calcium, a cement marker element, was found to be well correlated with Mg, S, Fe, Ni and Cu in the soils, and inversely proportional to the Si and Ti concentrations. From Ca/Si ratios and enrichment factors of the marker elements, it was found that soil contamination due to cement drops sharply with distance from the factories, and with increasing depth from the surface. 相似文献
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Faqir Muhammad Masood Akhtar M. Irfan Anwar M. Javed Arshed 《Veterinary research communications》2009,33(8):971-977
Ciprofloxacin was administered intravenously @ 5 mg/kg body weight to six healthy dogs. After a washout period of two weeks,
fever was induced by injecting Escherichia (E) coli endotoxin. Ciprofloxacin was administered again. Blood samples were collected at various time intervals and analyzed for
ciprofloxacin with HPLC. The kinetic analysis revealed the volume of distribution in healthy vs. febrile dogs as 2.12 ± 0.32
vs. 1.79 ± 0.43 L/Kg, respectively. The elimination half life was 2.23 ± 0.78 and 2.07 ± 0.74 hours in healthy and febrile
dogs, respectively. Similarly, dogs under healthy and febrile conditions showed comparable total plasma clearance of 0.66 ± 0.06
and 0.60 ± 0.07 L/Kg/h, respectively. All these and other investigated kinetic parameters were statistically non significant.
This study concludes that the pharmacokinetic behavior of ciprofloxacin is similar under healthy and febrile conditions. Thus,
the kinetic studies of fluoroquinolones conducted in normal/healthy animals may be used to depict the pharmacokinetic parameters
in diseased animals. 相似文献
3.
Abubakar M Rajput ZI Arshed MJ Sarwar G Ali Q 《Tropical animal health and production》2011,43(4):745-747
An outbreak resulting in mortality in Sindh Ibex (Capra aegagrus blythi) was investigated. There was a history of about 36 deaths (both young and adult) during the period of 1 month. Disease appeared
in a generalized form, affecting the respiratory and digestive systems. Major lesions were respiratory distress, pustules
on and in the mouth, ocular–nasal discharges, and severe diarrhea. The most significant lesion was the oculonasal discharges
and diarrhea. Deaths were mainly due to blindness, anorexia, diarrhea, and respiratory arrest. Both adult (mortality = 21)
and young (mortality = 15) animals were affected with the disease. Peste des petits ruminants virus (PPRV) antigen was detected
in the spleen, lung, lymph node, and swab samples by immunocapture enzyme-linked immunosorbent assay. Spleen and lung samples
were also tested and found positive for the presence of F-gene of PPRV by polymerase chain reaction. Thirteen of 20 serum
samples from nearby sheep and goats were found positive for antibodies to PPRV. The disease threatened the huge population
of ibex in the wild life park, which was spread over a large area, but vaccination of the domestic population of sheep and
goats in the surrounding villages appeared to control the disease. 相似文献
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Helgadottir A Thorleifsson G Manolescu A Gretarsdottir S Blondal T Jonasdottir A Jonasdottir A Sigurdsson A Baker A Palsson A Masson G Gudbjartsson DF Magnusson KP Andersen K Levey AI Backman VM Matthiasdottir S Jonsdottir T Palsson S Einarsdottir H Gunnarsdottir S Gylfason A Vaccarino V Hooper WC Reilly MP Granger CB Austin H Rader DJ Shah SH Quyyumi AA Gulcher JR Thorgeirsson G Thorsteinsdottir U Kong A Stefansson K 《Science (New York, N.Y.)》2007,316(5830):1491-1493
The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases. 相似文献
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