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Sharavdorj Khulan Jang Yeongmi Byambadorj Ser-Oddamba Cho Jin-Woong 《Journal of Crop Science and Biotechnology》2021,24(5):545-554
Journal of Crop Science and Biotechnology - Cool-season forage crops Alfalfa (Medicago sativa L.), Red clover (Trifolium pratense L.), Tall fescue (Festuca arundinacea Schreb.), Timothy grass... 相似文献
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Hoang MH Houng SJ Jun HJ Lee JH Choi JW Kim SH Kim YR Lee SJ 《Journal of agricultural and food chemistry》2011,59(12):6798-6805
To investigate the hypocholesterolemic mechanism of barley in vivo, six-week-old C57BL/6J mice were fed a high-fat diet (HFD) or high-fat diet containing barley (HFD-B) for seven weeks. Total and LDL cholesterol concentrations were significantly reduced in the HFD-B group while fecal cholesterol and bile acid was increased. Real-time PCR and immunoblot analysis revealed the induction of FXR expression, which in turn suppressed the expression of ASBT and NPC1L1 in the HFD-B group compared with the controls. In the liver, the expression of HMG-CoA reductase was significantly reduced while LDL receptor expression was unaltered in the HFD-B group compared with the controls. Our data suggest that the hypocholesterolemic effects of barley are primarily the result of reduced dietary cholesterol uptake and bile acid resorption. Reduced expression of intestinal ASBT and NPC1L1 may play a key role in the regulation of dietary cholesterol and bile acid metabolism in mice consuming a diet containing barley. 相似文献
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