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排序方式: 共有563条查询结果,搜索用时 15 毫秒
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Alessandra Bertoli Anthea LoBue Luca Quattrini Stefania Sartini Beatrice Polini Sara Carpi Francesco Paolo Frontini Graziano Di Giuseppe Graziano Guella Paola Nieri Concettina La Motta 《Marine drugs》2022,20(11)
Euplotin C is a sesquiterpene of marine origin endowed with significant anti-microbial and anti-tumor properties. Despite the promising functional profile, its progress as a novel drug candidate has failed so far, due to its scarce solubility and poor stability in aqueous media, such as biological fluids. Therefore, overcoming these limits is an intriguing challenge for the scientific community. In this work, we synthesized β-cyclodextrin-based nanosponges and investigated their use as colloidal carriers for stably complex euplotin C. Results obtained proved the ability of the carrier to include the natural compound, showing remarkable values of both loading efficiency and capacity. Moreover, it also allowed us to preserve the chemical structure of the loaded compound, which was recovered unaltered once extracted from the complex. Therefore, the use of β-cyclodextrin-based nanosponges represents a viable option to vehiculate euplotin C, thus opening up its possible use as pharmacologically active compound. 相似文献
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Relationship between serum cortisol levels and some physiological parameters following reining training session in horse
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Stefania Casella Irene Vazzana Elisabetta Giudice Francesco Fazio Giuseppe Piccione 《Animal Science Journal》2016,87(5):729-735
The changes of cortisol, red blood cells (RBC), hemoglobin (Hb), hematocrit (Hct), heart rate (HR), respiratory rate (RR) and rectal temperature (RT) were evaluated after a reining training session in eight Quarter Horses. All parameters were measured before exercise (T0), immediately after exercise (T1), 1 h after exercise (T2), 2 h after exercise (T3) and 24 h after exercise (T4). One‐way analysis of variance (ANOVA) for repeated measures, followed Bonferroni's post hoc test, showed a significant effect of the reining training session (P < 0.0001) on cortisol, RBC, Hb, Hct, HR, RR and RT. Simple linear regression analysis showed the positive correlation (P < 0.05) between cortisol changes and variations of studied parameters in T1, T3 and T4. Exercise‐induced cortisol concentrations reflect the physiological response of reining training, suggesting that the changes observed are useful to assess the performance in reining horses and their reining training adaptability. 相似文献
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Davide Piacentino Giuseppe Espa Danila Filipponi Diego Giuliani 《Growth and change》2017,48(3):359-389
This article contributes to the literature on firm demography and regional development in at least three different ways. First, consumption, rather than employment, which is the most common variable seen in literature, is used to measure the impact of firm demography on regional development. Second, while the literature is mainly focused on the relationship between new business formation and regional development, we investigate both entry and exit flows of firms. Third, we decompose each of these flows into spatial and sectoral components. The empirical investigation looks at the Italian regions with reference to the period 2004–2009. Results seem to be substantially divergent between the South and the rest of Italy. 相似文献
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Genomic prediction for yields,processing and nutritional quality traits in cultivated potato (Solanum tuberosum L.)
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Current potato breeding approaches are hampered by several factors including costly seed tubers, tetrasomic inheritance and inbreeding depression. Genomic selection (GS) demonstrated interesting results regardless of the ploidy level, and can be harnessed to circumvent these problems. In this work, three GS models were evaluated using 50,107 informative SilicoDArT markers and 11 traits in two values for cultivation and use (VCU) potato trials. Two key breeding problems modelled included predicting the performance of (i) new and unphenotyped clones (cross‐validation) and (ii) a VCU using another as training set (TS). GS models performed comparably. Cross‐validation accuracy was high for D35, D45, DMW and BVAL, in ascending order. Prediction accuracies of the VCUs were highly correlated, but the best prediction was obtained for the smaller VCU using the bigger as TS. Cross‐validation and VCU prediction accuracies were higher when bigger TSs were used. The findings herein indicate that GS can be attractively integrated in potato breeding, particularly in early clonal generations to predict and select for traits with low heritability which would otherwise require more testing years, environments and resources. 相似文献
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The effects of starving and feeding on Dover sole (Solea solea,Soleidae, Linnaeus, 1758) stress response and early larval development
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Chiara Carla Piccinetti Marco Donati Giuseppe Radaelli Giovanni Caporale Gilberto Mosconi Francesco Palermo Lina Cossignani Roberto Salvatori Rocio Penuela Lopez Ike Olivotto 《Aquaculture Research》2015,46(10):2512-2526
In the view of an urgent necessity to improve the quantity and the quality of farmed fish species, there is a strong need to improve our basic knowledge on the effects of first feeding during the developmental stages of fish larvae. High mortality, mainly due to food deprivation or inappropriate food quality, has been observed in many larval fish species, but knowledge about the morphological, biochemical and molecular processes related to this topic is still poorly understood. The understanding of the early larval ontogeny as well as the larval nutritional requirements and the molecular and cellular mechanisms elicited by fish larvae during food deprivation and starvation are thus of primary importance. At this regard, this study investigates, in Dover sole larvae, the effects of starvation and starving/re‐feeding procedures at a morphological, histological, biochemical and molecular level. The results evidenced that starved larvae progressively decrease in growth, lipid content, affected their gastrointestinal tract and muscle development and increased cortisol and heat shock protein 70 levels. On the contrary, starved and re‐fed larvae showed, after the restoration of a favourable feeding condition, a compensatory growth. In conclusion, this is the first study analysing through a multidisciplinary approach the effects of food deprivation on the development of an important economic species, the Dover sole. 相似文献
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Summary The occurrence of layers of wood material beneath the soil of the fossil forest of Dunarobba (Italy) has provided the opportunity to study a differently degraded wood formed in the same environment of the fossil forest. The samples of subsoil have almost completely lost their polyose and cellulose fractions and, moreover, were deprived of most of their low and medium MW terpenes so that some phenolic diterpenes were revealed. The identified ones were ferruginol, podocarpodiol, traces of sugiol and a compound whose mass spectrum shows some similarities with that of sugiol. A family of compounds with ketonic structure was also detected: in particular tridecanone, pentadecanone and heptadecanone.Dr. G. Scarascia Mugnozza and Dr. Francesca Bozzano are thanked for fossils donation and Prof. Pasquale Miraglino for mass spectrometry analyses 相似文献
10.
Summary Some fossil woods, differing in botanical species, age, degree of degradation and chemical composition, were analysed with respect to their acid structure. A comparison was carried out with corresponding modern species which, in the case of softwoods, contain carboxylic groups as well as ester groups in almost equal amounts. Moreover the former are subdivided into protonated (20%) and salified forms (80%). The determination of the acid structures in woods was made by means of cation exchange measurements.In all examined fossils the initially protonated form is changed into the salified one because of the leaching carried out by water containing soluble salts. Despite the loss of polyoses, an increase in the content of carboxylic groups was achieved due to hydrolysis of the ester groups. In more degraded samples the amount of carboxylic groups was larger than in the other fossils even if the former possessed only traces of polyoses due to an attack on lignin assessed by acidity of the trifluoroacetic (TFA) derivatives. Proof of these changes and further information on fossils were obtained by I.R. spectroscopy.The authors wish to thank Prof. D. Fengel for the fossils coming from Wackersdorf (Germany) 相似文献