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排序方式: 共有670条查询结果,搜索用时 15 毫秒
1.
Fortes Maira Salomão Lopes-Mori Fabiana Maria Ruiz Caldart Eloiza Teles Constantino Caroline Evers Fernanda Pagliari Sthefany de Almeida Jonatas Campos Barros Luiz Daniel Freire Roberta Lemos Garcia João Luis Headley Selwyn Arlington Navarro Italmar Teodorico 《Tropical animal health and production》2018,50(2):413-419
Tropical Animal Health and Production - This study investigated the prevalence of caprine toxoplasmosis in goat herds from Southern Brazil by the indirect immunofluorescence assay (IFA), and... 相似文献
2.
Karianne Giller Fleten Astrid Hyldbakk Caroline Einen Sopisa Benjakul Berit Lkensgard Strand Catharina de Lange Davies Ýrr Mrch Kjersti Flatmark 《Marine drugs》2022,20(12)
Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid drug clearance from the peritoneal cavity is a major challenge. Aiming to delay drug absorption and reduce toxic side effects, cabazitaxel (CAB)-loaded poly(alkyl cyanoacrylate) (PACA) nanoparticles were encapsulated in alginate microspheres. The PACAlg alginate microspheres were synthesized by electrostatic droplet generation and the physicochemical properties, stability, drug release kinetics, and mesothelial cytotoxicity were analyzed before biodistribution and therapeutic efficacy were studied in mice. The 450 µm microspheres were stable at in vivo conditions for at least 21 days after intraperitoneal implantation in mice, and distributed evenly throughout the peritoneal cavity without aggregation or adhesion. The nanoparticles were stably retained in the alginate microspheres, and nanoparticle toxicity to mesothelial cells was reduced, while the therapeutic efficacy of free CAB was maintained or improved in vivo. Altogether, this work presents the alginate encapsulation of drug-loaded nanoparticles as a promising novel strategy for the treatment of peritoneal metastasis that can improve the therapeutic ratio between toxicity and therapeutic efficacy. 相似文献
3.
Ilyas Siddique Caroline Gutjahr Gamini Seneviratne Broder Breckling Sudheera W. Ranwala Ian J. Alexander 《Biology and Fertility of Soils》2007,44(1):163-170
Topsoil properties were determined in forest gardens established about 20 years ago on eroded grassland soils (abandoned tea
lands) in the wet zone of the Sri Lankan highlands. They were compared with adjacent, eroded grasslands (abandoned tea lands)
on strongly weathered soils vs soils at earlier stages of pedogenic development in a two-way analysis of variance. Soil pH
in forest gardens was, on average, 6.1, nearly one unit higher than in the adjacent grasslands. In the garden soils, the cation
exchange capacity (CEC measured at pH 4.8) was nearly double, exchangeable calcium concentrations five times and exchangeable
magnesium three times as high as in the grasslands soils. Total soil N content was found to be nearly 40% higher in the gardens.
Topsoil gravel contents in the gardens were less than half as high as in the grasslands. The increases in exchangeable bases
and N in gardens, relative to grasslands, were attributed to increased nutrient retention and acquisition. Higher retention
was partly due to the higher CECpH4.8, and probably to reduced erosion and increased, continuous fine root density in the garden topsoils. Higher field CEC in
gardens was likely to result from generally higher C contents and from the reversal of acidification, presumably caused by
base accumulation and decomposition processes. Our results suggest that forest garden establishment on degraded grasslands
can lead to accumulation of mobile nutrients in the topsoil, probably due to increased nutrient retention, subsoil uptake
and litter input exceeding nutrient uptake by the standing biomass. 相似文献
4.
Brouns F Arrigoni E Langkilde AM Verkooijen I Fässler C Andersson H Kettlitz B van Nieuwenhoven M Philipsson H Amado R 《Journal of agricultural and food chemistry》2007,55(4):1574-1581
There is a growing interest in highly fermentable dietary fibers having the potential to reduce risks of disease through the production of short-chain fatty acids (SCFA). Recently a digestion-resistant retrograded maltodextrin (RRM), classified as type 3 resistant starch was developed. Systematic work to determine its molecular and physiological properties was carried out to determine (1) the fraction resistant to digestion in vitro and in vivo, (2) its postconsumption effect on blood glucose in healthy volunteers, and (3) its in vitro fermentation pattern, at different ages, by use of pooled fresh human fecal inoculum. RESULTS: The digestion resistant fraction obtained in vivo from ileostomy patients (59.4%) is similar to that obtained by the AOAC method for measuring retrograded resistant starch (59.7%). The relative glycemic response after consumption of 50 g of RRM was 58.5% compared to glucose set as 100%. When exposed to colonic microbiota, in vitro obtained indigestible fractions behave similarly to those obtained in vivo in ileostomy patients. Fermentation of RRM and production of butyric acid is negligible during the first months of life but develops subsequently during weaning. In adults, RRM fermentation results in a high yield of SCFA, with butyrate representing 21-31 mol % of total SCFA. The high yield of SCFA during colonic fermentation, observed from weaning age on, as well as the potential to help reduce glycemic load may be of benefit to a number of health-related functions in the host. Further study on clear clinical end points is warranted. 相似文献
5.
Breadmaking is a complex process that involves a series of parameters that must be controlled. Rheological measurements are often used to predict the behavior of wheat dough during processing and the quality of the final product. There are many different dietary fiber sources that can be used to enhance the nutritional quality of bread. However, they will affect processing and final product quality. Response surface methodology (RSM) was employed to study the effects of adding different dietary fiber sources (wheat bran, resistant starch, and locust bean gum) on farinographic parameters of wheat flour. The experiments were conducted according to a 23 central composite rotational design (CCRD). With the experimental results or responses (farinographic parameters), the effect of each variable was calculated and the interactions between them were determined. Models that explain the effects of the different fiber sources on water absorption, arrival time, dough development time, and mixing tolerance index of wheat flour were established. The fiber sources interacted for some of the parameters analyzed, demonstrating that if two or more sources of dietary fiber are present in the mix, they might act different to what would be expected of the sum of them. It was also noticed that for most parameters, wheat bran and locust bean gum had a greater influence on farinographic parameters than resistant starch. The simultaneous presence of the three fibers, within the ranges studied, contributed to an increase in water absorption, arrival time, and mixing tolerance index, and to a reduction in departure time and dough stability. 相似文献
6.
Floriane Boullot Caroline Fabioux Hlne Hgaret Pierre Boudry Philippe Soudant Evelyne Benoit 《Marine drugs》2021,19(7)
Pacific oysters (Crassostrea gigas) may bio-accumulate high levels of paralytic shellfish toxins (PST) during harmful algal blooms of the genus Alexandrium. These blooms regularly occur in coastal waters, affecting oyster health and marketability. The aim of our study was to analyse the PST-sensitivity of nerves of Pacific oysters in relation with toxin bio-accumulation. The results show that C. gigas nerves have micromolar range of saxitoxin (STX) sensitivity, thus providing intermediate STX sensitivity compared to other bivalve species. However, theses nerves were much less sensitive to tetrodotoxin. The STX-sensitivity of compound nerve action potential (CNAP) recorded from oysters experimentally fed with Alexandrium minutum (toxic-alga-exposed oysters), or Tisochrysis lutea, a non-toxic microalga (control oysters), revealed that oysters could be separated into STX-resistant and STX-sensitive categories, regardless of the diet. Moreover, the percentage of toxin-sensitive nerves was lower, and the STX concentration necessary to inhibit 50% of CNAP higher, in recently toxic-alga-exposed oysters than in control bivalves. However, no obvious correlation was observed between nerve sensitivity to STX and the STX content in oyster digestive glands. None of the nerves isolated from wild and farmed oysters was detected to be sensitive to tetrodotoxin. In conclusion, this study highlights the good potential of cerebrovisceral nerves of Pacific oysters for electrophysiological and pharmacological studies. In addition, this study shows, for the first time, that C. gigas nerves have micromolar range of STX sensitivity. The STX sensitivity decreases, at least temporary, upon recent oyster exposure to dinoflagellates producing PST under natural, but not experimental environment. 相似文献
7.
Denise C. Lambkin Kerry H. Gwilliam Caroline Layton Matt G. Canti Trevor G. Piearce Mark E. Hodson 《Pedobiologia》2011
Earthworms secrete granules of calcium carbonate. These are potentially important in soil biogeochemical cycles and are routinely recorded in archaeological studies of Quaternary soils. Production rates of calcium carbonate granules by the earthworm Lumbricus terrestris L. were determined over 27 days in a range of soils with differing chemical properties (pH, organic matter content, water holding capacity, bulk composition, cation exchange capacity and exchangeable cations). Production rate varied between soils, lay in the range (0–4.3 mg) earthworm?1 d?1 with an average rate of (0.8 mg) earthworm?1 d?1 and was significantly correlated (r = 0.68, P ≤ 0.01) with soil pH. In a second experiment lasting 315 days earthworms repeatedly (over periods of 39–57 days) produced comparable masses of granules. Converting individual earthworm granule production rates into fluxes expressed on a per hectare of land per year basis depends heavily on estimates of earthworm numbers. Using values of 10–20 L. terrestris m?2 suggests a rate of . Data obtained from flow-through dissolution experiments suggest that at near neutral pH, granule geometric surface area-normalised dissolution rates are similar to those for other biogenic and inorganic calcites. Fits of the data to the dissolution relationship r = k(1 ? Ω)n where r = dissolution rate, k = a rate constant, Ω = relative saturation and n = the reaction order gave values of k = 1.72 × 10?10 mol cm?2 s?1 and n = 1.8 for the geometric surface area-normalised rates and k = 3.51 × 10?13 mol cm?2 s?1 and n = 1.8 for the BET surface area-normalised rates. In 196 day leaching column experiments trends in granule dissolution rate referenced to soil chemistry corresponded to predictions made by the SLIM model for dissolution of limestone in soil. If soil solution approaches saturation with respect to calcium carbonate, granule dissolution will slow or even stop and granules be preserved indefinitely. Granules have the potential to be a small but significant component of the biogeochemical cycling of C and Ca in soil. 相似文献
8.
9.
Caroline Carvalho de Oliveira Fabiana Villa Alves Roberto Giolo de Almeida Érick Lemes Gamarra Severino Delmar Junqueira Villela Paulo Gustavo Macedo de Almeida Martins 《Agroforestry Systems》2018,92(6):1659-1672
The objective was to evaluate the animal thermal comfort indices from two integrated crop-livestock-forestry (ICLF) systems. For this, temperature–humidity index (THI), black globe temperature and humidity index (BGHI), and the radiant thermal load (RTL) were assessed. Two ICLF (ICLF-1 and ICLF-2) systems and one control system were established. On the ICLF systems, the arboreal component was the eucalyptus tree (Eucalyptus grandis × Eucalyptus urophylla; H13 clone), planted in simple wide-spaced rows. The ICLF-1 system had a tree spacing of 14 × 2 m with 357 trees per hectare, and the ICLF-2 had a tree spacing of 22 × 2 m with 227 trees per hectare. The control system had five scattered native trees per hectare, pertaining to Gochnatia and Dipteryx species. The forage component in all three systems was piatã-grass (Brachiaria brizantha cv. BRS Piatã). The experimental design was a randomized block in a sub-subplot design scheme with four replications. The presence of shade provided by the trees offered better conditions of animal comfort when compared with the condition of full sun. The ICLF-1 system, with higher tree density, provided better indicators for thermal comfort, THI, BGHI, and RTL when compared with the condition of full sun, while ICLF-2 was no different than ICLF-1 for BGHI. 相似文献
10.
Audrey G. Quentin Elizabeth A. Pinkard Christopher L. Beadle Timothy J. Wardlaw Anthony P. O’Grady Stephen Paterson Caroline L. Mohammed 《Annals of Forest Science》2010,67(2):203-203