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Wilson JA Heath AC Stringfellow L Haack NA Clark AG 《New Zealand veterinary journal》1996,44(5):185-187
Four groups of five Romney lambs were treated by plunge dipping with one of four registered organophosphorus flystrike preventatives. Untreated lambs acted as controls. The sheep were challenged at weekly intervals with larval implants of organophosphate-susceptible and -resistant strains of Lucilia cuprina. All four treatments provided 19-21 weeks protection against susceptible larvae but chlorfenvinphos provided the longest protection (16-17 weeks), followed by propetamphos (15-16 weeks), dichlofenthion (10-13 weeks) and diazinon (9-13 weeks), against the resistant strain. 相似文献
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Inbred rodent studies have demonstrated that cutaneous hypersensitivity reactions are exacerbated in stress-susceptible, and attenuated in stress-resistant strains of mice. This physiological response was, in part, mediated by activation of the hypothalamic-pituitary-adrenal axis during the acute restraint stress. A study was conducted to examine whether or not cutaneous hypersensitivity reactions are also associated with variable cortisol responsiveness to inflammatory stress in an outbred ovine population. High (H), medium (M), and low (L) cortisol responsive sheep were identified from a population of 110 females based on their estimated breeding values for cortisol concentration measured 4 h post-systemic challenge with Escherichia coli endotoxin (400 ng kg(-1)). Cutaneous hypersensitivity reactions to phytohaemagglutinin (PHA), 1-chloro-2, 4-dinitrobenzene (DNCB), and Candida albicans cellular antigen (CAA) were measured in these variable cortisol-responding sheep, in addition to serum interleukin (IL)-6, interferon (IFN)-gamma, and ovalbumin (OVA)-specific IgG concentrations. When compared to the M cortisol responders, both H and L cortisol responders had significantly greater cutaneous swelling during the elicitation phase in response to DNCB (P < 0.05) and CAA (P < 0.05); a similar but not significant trend was observed during the PHA challenge. The primary, but not the secondary, IgG response to OVA was significantly lower in the H and L cortisol responders when compared to the M cortisol responders. Differences in serum IL-6 or IFN-gamma concentration were not observed across variable cortisol-responsive groups. Together, these results demonstrate that cutaneous hypersensitivity reactions are enhanced in outbred H and L cortisol-responding sheep, independent of systemic modulation by IL-6 and IFN-gamma. 相似文献
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本试验旨在研究芪草提取物对蛋鸡产蛋性能、蛋品质及胆固醇代谢的影响。试验选用3 360只45周龄的大午金凤蛋鸡,随机分成2个组,每组12个重复,每个重复140只鸡。对照组饲喂基础饲粮,试验组在基础饲粮中添加400 mg/kg的芪草提取物。试验期12周。结果表明:1)试验第8、12周,试验组蛋鸡的产蛋率、料蛋比显著高于对照组(P 0. 05)。2)试验第8、12周,试验组鸡蛋的蛋白高度、哈氏单位均显著高于对照组(P0.05);试验第12周,试验组鸡蛋的蛋壳强度、蛋壳厚度均显著高于对照组(P0.05)。3)试验第12周,试验组蛋鸡的血清总胆固醇含量显著低于对照组(P0.05),试验组蛋鸡的肝脏中3-羟-3-甲基戊二酸单酰辅酶A还原酶(HMGR)和卵巢中极低密度脂蛋白受体(VLDLR)基因表达水平显著低于对照组(P0.05)。4)试验第4~12周,试验组鸡蛋的蛋黄胆固醇含量逐渐降低;试验第12周,试验组鸡蛋的蛋黄胆固醇含量显著低于对照组(P0.05)。由此可见,饲粮中添加芪草提取物能提高蛋鸡的产蛋性能,改善鸡蛋品质,可通过调节血清中脂肪代谢指标和抑制HMGR、VLDLR基因表达降低鸡蛋蛋黄胆固醇含量。 相似文献
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作为一家三级专科医院,郑州艾格眼科医院秉承"专业的才是最好的"及"百年艾格"的办院理念,从发展学术和技术人手,关爱社会,奉献社会,让患者亲身体验了专科医院的服务特色和技术.近日,记者走访了郑州艾格眼科医院董事长刘保松博士. 相似文献
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区域尺度土壤入渗特征参数的变异性研究 总被引:1,自引:0,他引:1
以杨凌地区为例,进行野外双环入渗试验研究,运用2种常用模型(Kostiakov模型和Philip模型)对土壤入渗参数进行模拟。在分析土壤特征参数,寻求适合区域尺度的最优入渗模型同时,对土壤的状态变量进行标定并研究标定系数的空间变异性,研究结果表明:Philip模型可作为区域最优入渗模型,土壤入渗特征参数存在明显的空间变异性,标定系数aA比as对模型参数的标定效果好,且在较大范围内存在一定的趋势性,有较好的预测效果。因此,可根据标定系数随机模拟得到某一具体时刻的土壤入渗量的空间分布,为定量分析土壤水分运动、研究土壤水分入渗的空间分布提供理论基础。 相似文献
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Neurotoxicity complicates the use of several commonly administered chemotherapeutic agents (platinum based alkylating agents, taxanes and vinca alkaloids), with chemotherapy-induced peripheral neuropathy being the most common manifestation. Structural damage to the peripheral nervous system results in positive symptoms, e.g., allodynia, hyperalgesia and pain with unpleasant features as burning and shooting. Patients are unable to complete full or optimal treatment schedules. The pathophysiologic basis of nerve injury in chemotherapy-induced peripheral neuropathy is incompletely understood and appears to be unique for each class of the chemotherapeutic agents. Erythropoeitin (EPO), a well-established hematopoietic factor, is a very effective and widely used treatment for anemia in cancer patients undergoing chemotherapy. It also possesses generalized neuroprotective and neurotrophic properties. Co-treatment of chemotherapy and erythropoietin has been proposed for preventing or reversing the disabling peripheral neuropathy induced by the different chemotherapeutic agents. This study first describes the pathophysiological background of the clinically relevant chemotherapeutic agents-inducing peripheral neuropathy. Secondly, the possible mechanisms that might underlie the neuroprotective effect of erythropoietin in chemotherapy-induced neuropathy. Further clinical trials of EPO in cancer patients receiving chemotherapy and suffering from neurological symptoms seem to be warranted in the future. This might improve the quality of life in cancer patients. 相似文献