The thermal antinociceptive effects of a high-concentration formulation of buprenorphine alone or followed by hydromorphone in conscious cats

ObjectiveTo evaluate the thermal antinociceptive effects of a high-concentration formulation of buprenorphine alone or followed by hydromorphone in conscious cats.Study designRandomized, blinded, placebo-controlled crossover study design.AnimalsA total of six purpose-bred, adult female ovariohysterectomized Domestic Short Hair cats.MethodsCats were allocated into three treatments each consisting of two injections, subcutaneous then intravenous (IV) administration, 2 hours apart: treatment SS, two injections of 0.9% saline; treatment BS, buprenorphine (0.24 mg kg^–1, 1.8 mg mL^–1) and saline; and treatment BH, buprenorphine (0.24 mg kg^–1) and hydromorphone (0.1 mg kg^–1). Skin temperature (ST) and thermal threshold (TT) were recorded before (baseline) and for 24 hours following first injection. TT data were analyzed using mixed linear models and a Benjamini–Hochberg sequential adjustment procedure (p < 0.05).ResultsThere were no significant differences among treatments for baseline ST and TT values, treatment SS over time and between treatments BS and BH. Compared with baseline, TT was significantly increased at all time points in treatments BH and BS except at 2 hours in treatment BS. TT was significantly higher than SS at 3–18 hours and 4–12 hours for treatments BS and BH, respectively. Maximal increases in TT were 47.5 °C at 2 hours, 53.9 °C at 3 hours and 52.4 °C at 6 hours in treatments SS, BS and BH, respectively.Conclusions and clinical relevanceAdministration of IV hydromorphone following high-concentration buprenorphine provided no additional antinociception and decreased the duration of effect when compared with high-concentration buprenorphine alone. Alternative analgesics should be considered if additional analgesia is required after administration of high-concentration buprenorphine.     

Computation of Three-Dimensional Temperature Distribution and Thermal Analysis to Integrated Circuit Substrates

The exact three di me nsional temperatu re distribution and thermal analysiS to inte-grated circuit substrates have been presen ted by means of numerical method of a fin ite difference.Thismethed.which will overcome the di fficuItv of mathematical deduction mav be consltieredas an analytical way aided by com puters for thermal design of electron ic compon ents.     

Influence of Indoor Thermal Environment on Thermal Comfort of Human Body

Analyses the thermal environment parameters from physiological aspect and from psychological aspect respectively. Introduces the conception of thermal comfort of human body from heat balance aspect. Presents some measures to improve indoor thermal environment and advance thermal comfort of human body. Analyses the influence of indoor thermal environment on thermal comfort of human body and some questions on the aspect of this research, also puts forward some advices.     

A STUDY ON HEAT AND MOISTURE STATE OF HULL LAYER FOR THERMAL INSTULATION OF A COLD STORAGE

This paper analyses the thermal moist characteristics of the hull layer beside an air layer at lower temperature in an envelope for a cold storage and presents a new method of waterproof by air layer. With test data from engineering practice, the theory on the barrier of self moisture proof at the surface sublayer of the hull layer in an attic on a cold storage is proven. The dried zone about three phase point is confirmed. It is a new knowledge for thermophysics on thermal design of a cold storage with an optimum thermal performance.     

潮州三百门电厂冷却水排放的数值模拟研究

海湾及潮汐河口的冷却水工程研究近年来受到人们的重视，由于受到潮汐的影响，其冷却水布置及热污染特性比河道及水库型更为复杂。采用数值模拟的方法，首先对电厂附近的潮流特性及冷却水输移扩散进行模拟计算，研究了电厂近海水域的水动力结构及其对冷却水排放的影响，给出电厂取水温升及热污染范围，为电厂取水设计工作提供依据。     

煤与生物质恒温热解比较研究

在实验室自制固定床热解反应器中,选择了两种煤(神华煤和灵武煤)和3种生物质(花生壳、核桃壳和木屑)作为实验材料,定量化分析比较了恒温热解和同温热解停留时间对煤与生物质热解产氢及热解油、热解焦产率的影响.研究认为:实验用煤与生物质催化热解表现出基本相同的热解趋势,即提高热解温度和延长热解时间(对生物质添加合适催化剂)都有利于产氢;对煤而言,提高热解温度和延长热解时间还利于热解油生成,但对生物质而言,效果不很明显.