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AIM: To observe the effects of irbesartan and perindopril on pressure-overload cardiac hypertrophy in rats. METHODS: 40 male adult Sprague Dawley rats were divided into 5 groups. One was sham operation group, other four were aortic banding groups. One week after operation, all rats were gavaged with normal saline, perindopril, irbesartan or combination of perindopril and irbesartan. Morphometric determination, calcineurin (CaN) expression, CaN and sarcoplasmic reticulum (SR) Ca2+-ATPase activity were performed at the end of 6 weeks of drug intervention. RESULTS: Left ventricular mass index (LVMI), transverse diameter of myocardical cell (TDM), CaN activity were remarkably decreased after drug intervention and this decrease was most remarkable in the combination group. SR Ca2+-ATPase activity increased after drug intervention, especially in the combination group. CaN expression in myocardium were remarkably decreased after drug intervention. LVMI was positively correlated with TDM and CaN, negatively correlated with SR Ca2+-ATPase. CONCLUSION: Both irbesartan and perindopril decrease CaN activity, increase SR Ca2+-ATPase activity and combination of them has synergic effects on regressing of ventricular hypertrophy. 相似文献
203.
Taylor PM Steagall PV Dixon MJ Ferreira TH Luna SP 《Research in veterinary science》2007,83(3):369-375
A model of nociceptive threshold determination was developed for evaluation of NSAID analgesia in cats. In a crossover study, eight cats received carprofen (4 mg/kg), buprenorphine (0.01 mg/kg) or saline (0.3 ml) subcutaneously before intradermal kaolin injection on the antebrachium to induce mild inflammation. Pressure thresholds were measured at the injected site using blunt-ended pins advanced by manual inflation of a bladder within a bracelet. Bladder pressure was recorded as threshold (PT) at the behavioural end point. Baseline PT were recorded before kaolin injection (time 0). PT was measured at 2-10 h intervals for 52 h. PT below the lower 95% confidence interval (CI) of baseline values indicated hyperalgesia. After saline, hyperalgesia was detected from 2-6 h, 22-26 h, and at 30 and 36 h. After carprofen, PT remained within the 95% CI. After buprenorphine, PT remained within the 95% CI except at 2h. Carprofen and to some extent buprenorphine, prevented inflammatory hyperalgesia. 相似文献
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Meschan EM Peham C Schobesberger H Licka TF 《Veterinary journal (London, England : 1997)》2007,173(3):578-584
As there is no statistical evidence that saddle fit influences the load exerted on a horse's back, this study was performed to assess the hypothesis that the width of the tree significantly alters the pressure distribution on the back beneath the saddle. Nineteen sound horses were ridden at walk and trot on a treadmill with three saddles differing only in tree width. Kinetic data were recorded by a sensor mat. A minimum of 14 motion cycles were used in each trial. The saddles were classified into four groups depending on fit. For each horse, the saddle with the lowest overall force (LOF) was determined. Saddles were classified as "too-narrow" if they were one size (2 cm) narrower than the LOF saddle, and "too-wide" if they were one size (2 cm) wider than the LOF saddle. Saddles two sizes wider than LOF saddles were classified as "very-wide". In the group of narrow saddles, the pressure in the caudal third (walk 0.63 N/cm(2)+/-0.10; trot 1.08 N/cm(2)+/-0.26) was significantly higher compared to the LOF saddles (walk 0.50 N/cm(2)+/-0.09; trot 0.86 N/cm(2)+/-0.28). In the middle transversal third, the pressure of the wide saddles (walk 0.73 N/cm(2)+/-0.06; trot 1.52 N/cm(2)+/-0.19) and very-wide saddles (walk 0.77 N/cm(2)+/-0.06; trot 1.57 N/cm(2)+/-0.19) was significantly higher compared to LOF saddles (walk 0.65 N/cm(2)+/-0.10/ 0.63 N/cm(2)+/-0.11; trot 1.33 N/cm(2)+/-0.22/1.27 N/cm(2)+/-0.20). This study demonstrates that the load under poorly fitting saddles is distributed over a smaller area than under properly fitting saddles, leading to potentially harmful pressures peaks. 相似文献
205.
Curved laminated veneer lumber (LVL) for use in furniture-making was produced from glue-coated pieces of rotary-cut veneers that were assembled and pressed between molds. Pressure was applied until glue-lines were set and finally held in an assembly of the desired curvature. Pressure was an important factor during pressing of curved LVL. In this study we deduced some equations for designing the shape of molds and calculating the total pressure from the mechanics. The results are summarized as follows: (1) The position angle of every section of curved LVL assembly in molds on the horizontal and the total pressure during pressing can be calculated in relation to the shapes and dimensions of the curved LVL. (2) The pressure distributions in the glue-line measured using pressure-sensitive film were in good agreement with the glue-line unit pressure provided for the experiment and calculation. Therefore, the equations deduced in this study were suitable for calculating the position angle and pressure of curved LVL in molds. (3) The total pressure on curved LVL was greater than the pressure on straight LVL. The total pressure consisted of the pressure on the glue-lines of straight LVL with the same length and width as curved LVL plus the supplementary pressure needed to bend the veneers. (4) The total pressures and position angles of curved LVL in molds were affected by the shape, bent angle, and length of each section of curved LVL.The outline of this study was presented at the 48th annual meeting of the Japan Wood Research Society, Shizuoka, April 3, 1998 相似文献
206.
利用地面加密观测资料、常规探测资料和NCEP 1°×1°再分析资料等,从环流形势入手,通过对水汽通量、假相当位温、24 h变温、地面风场、湿焓和压能场等的诊断分析,研究此次暴雨过程的形成机制。结果表明,此次暴雨是在高层槽前和中低层切变南侧的西南气流中产生的;低空西南急流和低层西南风辐合为暴雨提供了充足的水汽,低层涡旋的辐合提供了垂直上升的动力,低层海上回流的冷空气是暴雨产生最直接的促发机制。高压能舌与等湿焓密集带呈带状,且走向一致,强湿焓平流出现时间比实际出现强降水的时间早。冷空气激发带状θse锋区能量释放,东北—西南向的强湿焓平流促使带状强对流的发生,闽东南部900~700 h Pa水汽通道畅通,但低层水汽不足,故仅在700 h Pa水汽通量高值中心形成暴雨,闽西北水汽匮乏,直接导致其未出现强降水。 相似文献
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210.
现代电控柴油机中共轨内压力的瞬态波动会直接影响到燃油喷射系统的喷油量的均衡。本文采用ASW软件建立了燃油喷射系统模型,设定平均压力波动量、试验商值和瞬态压力波动率3个参数,分析了高压共轨系统共轨管的容积、压力和长径比对共轨内压力波动产生的影响。 相似文献