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81.
João CA. Alves Ana MMP. dos Santos Ângelo DP. Fernandes 《Veterinary anaesthesia and analgesia》2018,45(1):123-128
Objective
To evaluate the feasibility and effectiveness of mesotherapy in dogs compared with a positive control group.Study design
Experimental, randomized, blinded study.Animals
Fifteen working police dogs with chronic back pain.Methods
Animals were divided randomly into control (CG; n = 5) and treatment groups (TG; n = 10). A combination of 140 mg lidocaine, 15 mg dexamethasone and 20 mg thiocolchicoside was administered to group TG along with a 70-day course of a placebo, administered as if it was carprofen. Carprofen was administered to Group CG for 70 days, at a dose adjusted to their weight. On day 0, an intradermal injection of Ringer’s lactate was also administered. Both groups were rested for 3 days and resumed normal activity over a 5-day period. Response to treatment, measured by the Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS), was evaluated before treatment (T0), after 15 days (T1) and 1 (T2), 2 (T3), 3 (T4), 4 (T5) and 5 (T6) months. Results were compared using a Mann–Whitney test or a paired samples t test.Results
When comparing CBPI results, no differences were found between groups TG and CG at T0 through T3 and in T6 and T7. Differences were observed in CBPI sections after the discontinuation of carprofen: at T4 [p = 0.02 for Pain Interference Score (PIS) and p = 0.03 for Pain Severity Score (PSS)] and T5 (p = 0.16 for PIS and p = 0.03 for PSS), with group TG having overall better results. Individual treatment results were considered successful in one dog of group CG (20%), whereas in group TG, success was higher (ranging from 78% at T1 to 22% at T7). No significant differences were registered with the HVAS.Conclusions and clinical relevance
Mesotherapy may be a promising treatment option for canine musculoskeletal-related pain. Further studies are required. 相似文献82.
Sabrina Lomax Evelyn Hall Lauren Oehlers Peter White 《Veterinary anaesthesia and analgesia》2018,45(3):366-373
Objective
To evaluate the efficacy of a vapocoolant spray (VS) to provide local anaesthesia for piglets during ear notching.Study design
Randomized study.Animals
Eleven 10 day old and forty 3–5 day old Large White piglets.Methods
Temperature validation studies using thermocouples and a temperature data logger were conducted on dead and live tissue to determine optimal spray distance and duration to reduce tissue temperature to below 10 °C. A behavioural trial was conducted to assess efficacy for ear notching. Piglets were randomly assigned to one of four treatment groups: positive control (POS; n = 10), VS (n = 10), lignocaine (LIG; n = 10) and negative control (NEG; n = 10). Spray was administered to the margin of each ear, from a distance of 10 cm, and for a duration of 2 seconds immediately prior to ear notching. Behavioural observation was used to assess movement and vocal response, with responses categorized as no response (0) and response (1).Results
Temperature and tissue validation studies indicated that a 2 second spray from 10 cm reduced tissue temperature to below 10 °C, and reduced response to stimulation of the skin with an 18 gauge needle (p < 0.001). There was a significant effect of treatment on response to ear notching (p < 0.001). The probability of a piglet to respond to ear notching was 98.7% for NEG piglets, compared with those treated with VS (5.3%), LIG (1.1%) and sham-notched piglets (0.9%).Conclusions and clinical relevance
This study contributes new data on the pain of ear notching in piglets. The application of a topical VS prior to ear notching reduced the antinociceptive response of piglets to the procedure, similar to that of a local anaesthetic. Cryoanaesthesia presents a simple and effective option for reducing the pain response to this simple husbandry procedure. 相似文献83.
Two-point ultrasound-guided transversus abdominis plane injection in canine cadavers – a pilot study
Emma K. Johnson Sébastien H. Bauquier Jennifer E. Carter Ted Whittem Thierry Beths 《Veterinary anaesthesia and analgesia》2018,45(6):871-875
Objective
This study evaluated the spread of a two-point transversus abdominis plane (TAP) injection in canine cadavers. Compared with previous techniques, the two-point TAP injection was developed to increase the consistency of local anaesthetic spread to the nerve segments T11, T12, L1, L2 and L3.Study design
Prospective experimental trial.Animals
Five fresh canine cadavers.Methods
Two-point TAP injections were performed under ultrasound guidance by a single trained individual in canine cadavers (15.7–43.0 kg). Each hemi-abdomen was infiltrated and evaluated independently for a total of 10 evaluations of the technique. The first injection was performed at the level of the costo-chondral junction of the thirteenth rib, and the second injection was performed cranial to the tuber coxae. Each injection comprised 0.3 mL kg–1 methylene blue solution (0.0015 mg mL–1). Ten minutes after the injections, abdominal wall dissection was performed, and any nerves stained for a minimum of 10 mm along their long axis were identified and recorded.Results
During all injections, separation of the internal oblique and transversus abdominis muscles was observed on ultrasound. On dissection, branches of T12, T13, L1, L2 and L3 were adequately stained in 30%, 100%, 100%, 90% and 90% of injections, respectively. No staining of branches of T11 occurred in any of the cadavers. In one hemi-abdomen, branches of L1 and L3, but not L2, were stained.Conclusions and clinical relevance
This study indicates that the two-point TAP injection delivers consistent dye dispersion to adequately stain branches of T13, L1, L2 and L3, with no coverage of T11 and poor coverage of T12, in fresh canine cadavers. An in vivo study using local anaesthetic should be performed to evaluate the analgesic efficacy of this technique in mid to caudal abdominal surgeries. 相似文献84.
85.
AIM: To investigate the difference between immune-related pain induced by antigen-special complex and inflammatory pain induced by formalin, and to observe the differential expression of p38 mitogen-activated protein kinase in spinal cord. METHODS: Thirty adult health SD rats were randomly divided into control group, formalin group and immune complex group (10 rats in each group). After the baseline tests were finished, 5 rats in each group underwent intrathecal administration of p38 MAPK inhibitor SB203580. The right hindpaw of the rats were injected with PBS, formalin or rat IgG immune complex. The thickness of hindpaw and pain behaviors were observed at time points of 0 min, 30 min, 1 h, 2 h, 4 h, 8 h and 12 h after injection. The expression levels of total and activated p38 MAPK in spinal cord were determined by Western blotting analysis. RESULTS: The rats in formalin group showed significant nociceptive behaviors immediately, such as licking foot, and limping with highly swollen foot which could touch the ground. The pain threshold was decreased rapidly 30 min after injection and alleviated after then. The pain threshold of the rats in immune complex group obviously decreased 4 h after injection without red swollen hindpaw. The expression of activated p-p38 MAPK in spinal cord in formalin group was significantly higher than that in immune complex group and control group (P<0.01). No statistic difference of p-p38 expression between immune complex group and control group, also no significant effects of SB203580 on pain behaviors in immune complex group were observed. CONCLUSION: Activated p38 MAPK contributes to the pathogenesis of inflammatory pain, but not to the pathogenesis of immune-related pain. The mechanism of immune-related pain is different from inflammatory pain induced by formalin. 相似文献
86.
用低功率氦氖激光照射绵羊后三里、耳根、通天、天门四穴,由腹壁、胸壁、下颌三部位测痛,结果表明,氦氖激光穴位照射确有提高痛阈的作用,但经统计学处理后发现痛阈提高的程度则因穴位、部位不同而不同。如照射后三里穴腹壁痛阈提高显著(p<0.05),照射通天穴胸壁痛阈提高显著(p<0.05),照射耳根穴三个测痛部位的痛阈提高皆不显著(p>0.05),照射天门穴痛阈提高的程度呈不规则变化。由此看出,激光穴位镇痛既具有全身普遍性,又具有相对特异性。 相似文献
87.
Impingement of the dorsal spinous processes (DSPs) is a common cause of pain and poor performance in sport horses, but there is limited information regarding regional differences in the prevalence and severity of DSP osseous lesions in the equine thoracolumbar spine. It was hypothesized that lesion severity would increase with horse age and height, and that severe lesions would be more prevalent in the mid-caudal thoracic region. The thoracolumbar spines of 33 horses were removed postmortem, disarticulated, and boiled out. The thoracic and lumbar DSPs were examined for the presence of proliferative or lytic osseous lesions of the DSPs. Age and height of the horses were recorded, and severity of pathologic changes at each vertebral level was scored using an ordinal grading system (grades 0–3) and a continuous visual analog scale (VAS). Osseous lesions of the DSPs were present at every vertebral level from C7–T1 to L6–S1, and 70% of horses had at least one lesion of severity grade 2 or higher. Grade 3 lesions were found in the cranial thoracic (T2–T4), mid-thoracic to cranial lumbar (T11–L1) and mid-lumbar (L4–L5) segments. Analysis of VAS data using analysis of variance indicated that increasing age and height were associated with more severe osseous lesions (P < .001). DSP osseous lesions occur frequently in horses with more severe lesions in the cranial thoracic, mid to caudal thoracic, and mid-lumbar regions. Lesions in the cranial thoracic and lumbar regions present a challenge for diagnostic imaging and may be underdiagnosed clinically. 相似文献
88.
M. Christoffersen DVM H. Lehn-Jensen DVM DVSc I.B. Bgh DVM DVSc 《Journal of Equine Veterinary Science》2007,27(1):32-36
In mares, pneumovagina develops because of perineal malconformation. This condition may aggravate to cause vaginitis, cervicitis, and endometritis. In animal models, visceral pain has been associated with genital infections causing hyperalgesia and allodynia in the affected organs. The pain from genital infections may be referred to dermal areas of the hindquarter.The aim of the current clinical case study was to determine whether performance problems attributable to hypersensitivity in dermal areas of the hindquarter, a classic symptom of nymphomania in the mare, may be caused by visceral pain resulting from irritative processes in the reproductive organs. Vulvoplastic surgery (Caslick operation) is a well-known treatment of mares in which poor perineal conformation is the underlying factor of genital infections. The current study is based on clinical examinations and performance of mares with hypersensitivity in dermal areas of the hindquarters before and after Caslick operation.Fourteen mares exhibiting performance problems such as kicking against the rider's legs, bolting, or refusing to move forward were selected for this study. Performance problems or stereotypic behavior were observed either permanently or intermittently during estrus. In 12 of 14 mares (86%), the performance problems were totally eliminated or diminished within 6 months after Caslick operation.The clinically observed performance improvement in the treated mares supports the hypothesis that problems attributable to hypersensitivity in dermal areas of the hindquarters may be caused by irritative processes in the labia vulvae, vestibulum, and vagina of the mare. 相似文献
89.
90.
Jenifer R. Gold Tamara L. Grubb Sherry Cox Lais Malavasi Nicholas L. Villarino 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2022,36(2):792
BackgroundThe repeated administration of high doses of gabapentin may provide better analgesia in horses than current clinical protocols.Hypothesis and ObjectivesAdministration of gabapentin at 40 and 120 mg/kg PO q 12 h for 14 days will not alter serum biochemistry findings or cause adverse effects. Our objectives were to evaluate the effect of gabapentin on serum biochemistry, physical examination, and plasma pharmacokinetics of gabapentin.AnimalsSix healthy adult mares.MethodsHorses received 40 and 120 mg/kg of gabapentin orally q 12 h for 14 days. Horses were examined and scored for ataxia and sedation daily. Serum biochemistry variables were analyzed before treatment and days 7 and 14 after gabapentin administration. Plasma disposition of gabapentin was evaluated after the first and last drug administration. Pharmacokinetic parameters were estimated using noncompartmental analysis.ResultsNo changes occurred in physiologic or biochemical variables. Median (range) maximal plasma gabapentin concentrations (μg/mL) after the last dose (day 15) were 7.6 (6.2‐11) and 22 (14‐33) for 40 mg/kg and 120 mg/kg doses respectively. Maximal concentration of gabapentin was reached within 1 hour after drug administration. Repeated administration of gabapentin resulted in a median (range) area under the curve (AUC0‐12 hours) last/first dose ratio of 1.5 (1.00‐2.63) and 2.92 (1.4‐3.8) for the 40 and 120 mg/kg regimens, respectively.Conclusion and Clinical ImportanceOur results suggest that horses tolerate gabapentin up to 120 mg/kg PO q 12 h for 14 days. The analgesic effect of the dosage regimens evaluated in our study warrants further research. 相似文献