Advances in apoptosis induced by natural drugs

Apoptosis, a form of cell death, has generated considerable interest in recent years. Much progress has been made on the apoptosis induced by natural drgus, including component or mixture of plant, animal, mineral or marine materials. This review discusses some of the natural drugs that induce apoptosis and the possible mechanisms.     

Effect of Siduqing decoction,a Chinese medicine,on survival rate and multiple organ dysfunction in mice challenged with LPS

AIM: To investigate the effect of siduqing decoction, a Chinese medicine, on survival rate and multiple organ dysfunction in mice challenged with LPS. METHODS: Mice were administered intragastrically with Siduqing decoction or distilled water (0.2 ml/10 g) twice a day for 3 days, two hours after Chinese herbal medicine treatment on day 3, LPS or normal saline was injected intraperitoneally, and survival rates in each group were recorded at 12-h intervals. In another experiment, mice were sacrificed at 12 h after LPS, lung, liver, kidney and small intestine were collected and processed for the H & E staining. In addition, Blood was collected at 10 h after LPS injection for determining alanine aminotransferase (ALT) activity, blood urea nitrogen (BUN) and creatinine (Cr) contents. RESULTS: At 96 h after LPS injection, the survival rate (27%, n=34) was lower in LPS group than Siduqing treatment group (65%, n=31, P<0.05). ALT activity, BUN and Cr contents in serum were higher in LPS group than control group, Siduqing treatment significantly attenuated a increase in ALT activity, BUN and Cr content in serum induced by LPS. Histological examination showed inflammatory injury in the lung and intestine, hemorrhage in the lung and kidney, degeneration, necrosis in the liver and kidney, while Siduqing treatment attenuated pathological changes induced by LPS. CONCLUSION: These data indicate that Siduqing has a protective effect against LPS-induced multiple organ injury and increases survival rate in mice challenged with LPS.     

Promising candidates in clinical trials against multidrug-resistant tuberculosis (MDR-TB) based on natural products

In the twenty first century the interest in new anti-tuberculosis drugs based on natural products, specially against MDR (multidrug-resistant) and XDR (extensively drug resistant) tuberculosis (TB) is growing, as indicated by the increasing number of publications in this field. Some natural products, semisynthetic or synthetic compounds based on nature are in clinical studies and are the subject of this article.     

猪用复合抗应激制剂配方的筛选试验

采用对比试验方法,研究不同组方抗应激制剂对断奶仔猪平均日增重、料肉比和仔猪下痢的影响。结果,B组平均日增重最高(367.00g),比A、C组高51.00g、33.50g,差异均极显著(P<0.01);D组料肉比最低(1.64);D组抑制仔猪下痢效果最好。表明,由免疫增强剂左旋咪唑为主药,结合中药黄芪、补骨脂、淫羊藿等,再添加电解质之配方药物抗应激作用最好。