Effect of anesthetic induction with propofol,alfaxalone or ketamine on intraocular pressure in cats: a randomized masked clinical investigation

ObjectiveTo compare the effect of propofol, alfaxalone and ketamine on intraocular pressure (IOP) in cats.Study designProspective, masked, randomized clinical trial.AnimalsA total of 43 ophthalmologically normal cats scheduled to undergo general anesthesia for various procedures.MethodsFollowing baseline IOP measurements using applanation tonometry, anesthesia was induced with propofol (n = 15), alfaxalone (n = 14) or ketamine (n = 14) administered intravenously to effect. Then, midazolam (0.3 mg kg^?1) was administered intravenously and endotracheal intubation was performed without application of topical anesthesia. The IOP was measured following each intervention. Data was analyzed using one-way anova and repeated-measures mixed design with post hoc analysis. A p-value <0.05 was considered significant.ResultsMean ± standard error IOP at baseline was not different among groups (propofol, 18 ± 0.6; alfaxalone, 18 ± 0.7; ketamine, 17 ± 0.5 mmHg). Following induction of anesthesia, IOP increased significantly compared with baseline in the propofol (20 ± 0.7 mmHg), but not in the alfaxalone (19 ± 0.8 mmHg) or ketamine (16 ± 0.7 mmHg) groups. Midazolam administration resulted in significant decrease from the previous measurement in the alfaxalone group (16 ± 0.7 mmHg), but not in the propofol group (19 ± 0.7 mmHg) or the ketamine (16 ± 0.8 mmHg) group. A further decrease was measured after intubation in the alfaxalone group (15 ± 0.9 mmHg).Conclusions and clinical relevancePropofol should be used with caution in cats predisposed to perforation or glaucoma, as any increase in IOP should be avoided.     

Comparison between mainstream (Capnostat 5) and a low-flow sidestream capnometer (Capnostream) in mechanically ventilated,sevoflurane-anesthetized rabbits using a Bain coaxial delivery system

ObjectiveTo evaluate agreement between end-tidal carbon dioxide (Pe′CO₂) and PaCO₂ with sidestream and mainstream capnometers in mechanically ventilated anesthetized rabbits, with two ventilatory strategies.Study designProspective experimental study.AnimalsA total of 10 New Zealand White rabbits weighing 3.6 ± 0.3 kg (mean ± standard deviation).MethodsRabbits anesthetized with sevoflurane were intubated with an uncuffed endotracheal tube (3.0 mm internal diameter) and adequate seal. For Pe′CO₂, the sidestream capnometer sampling adapter or the mainstream capnometer was placed between the endotracheal tube and Bain breathing system (1.5 L minute^–1 oxygen). PaCO₂ was obtained from arterial blood collected every 5 minutes. A time-cycled ventilator delivered an inspiratory time of 1 second and 12 or 20 breaths minute^–1. Peak inspiratory pressure was initially set to achieve Pe′CO₂ normocapnia of 35–45 mmHg (4.6–6.0 kPa). A total of five paired Pe′CO₂ and PaCO₂ measurements were obtained with each ventilation mode for each capnometer. Anesthetic episodes were separated by 7 days. Agreement was assessed using Bland-Altman analysis and linear mixed models; p < 0.05.ResultsThere were 90 and 83 pairs for the mainstream and sidestream capnometers, respectively. The mainstream capnometer underestimated PaCO₂ by 12.6 ± 2.9 mmHg (proportional bias 0.44 ± 0.06 mmHg per 1 mmHg PaCO₂ increase). With the sidestream capnometer, ventilation mode had a significant effect on Pe′CO₂. At 12 breaths minute^–1, Pe′CO₂ underestimated PaCO₂ by 23.9 ± 8.2 mmHg (proportional bias: 0.81 ± 0.18 mmHg per 1 mmHg PaCO₂ increase). At 20 breaths minute^–1, Pe′CO₂ underestimated PaCO₂ by 38.8 ± 5.0 mmHg (proportional bias 1.13 ± 0.10 mmHg per 1 mmHg PaCO₂ increase).Conclusions and clinical relevanceBoth capnometers underestimated PaCO₂. The sidestream capnometer underestimated PaCO₂ more than the mainstream capnometer, and was affected by ventilation mode.     

AN APPRONTMATE CALCULATING METHOD FOR WALL PLATES OF MAN'' S DRY GAS HOLDERS

The basic equations of wall plates of MAN' S dry gas holders are derived in this paper. According to the law of cylindrical bending given by the finite element results .we derive some approximate formula calculating the deflection and stresses of the wall plates from the basic equations. Compared with the known approximate calculating method.the method car. obviously increase the percision.     

New Method of Founding Profile Equations and Pressure Angle Formula to the Cylindrical Cam Mechanism with Slide Roller-Follower

According to existent problems on design and application of the cylindrical cam mechanism with the slide roller-follower, the one correct concept about profile design and pressure angle is presented. Based on this concept, the theoretical profile,practical profile,meshing surface equations and pressure angle formula of the cam mechanism are built up by using opp.rotation analysis and offset surface principle. This method is very simple and clear, and avoids the abstract analysing process in meshing principle. The mathematic models built by this paper can be used to design,manufacture and check this type of cam mechanism correctly, and also create conditions to make deeply meshing property analysis of this mechanism.     

Study on Mechanism of the Reinforcing Effect of Geogrid in Soil Dam

An experimental study on consolidation and drainage of two gravels with different grading was carried out using high - pressure large - scale tri - axial testing facility. A concept of equivalent surrounding pressure is introduced. An analysis was carried out on the effect and mechanism of reinforcement, experimental surrounding pressure and soil properties. Results show that the reinforcement can improve the strength and failure strain of the material and delay the failure of the soil. The effect of reinforcement of soil - gravel depends on the surrounding pressure and weathering of the gravel.     

Simulation of High Pressure Startu Poil Pum Pof Turbine

Dynamic mathematical model, which is based on the character of the 200 MW tubine lbricating oil system, is established by means of modularization. On the basis of dynamic mathematical models, simulation model of the startu Pprocess of hign pressure startu Poil pum Pis created with the Visual Fortran language. The validity of this model has been verified by the simulation experiments and analysis. The simulation helps to forecast the dynamic characteristic to high pressure startu Poil pum Pand have some directive significance to design method of lubricating oil system.     

地下滴灌灌水器出口正压试验研究

通过试验 ,研究了灌水器类型、流量、工作压力和土壤初始含水量对地下滴灌灌水器出口正压的影响规律。结果表明 :灌水器埋入土壤后 ,其出流由于受土壤等因素的限制 ,在灌水器出口处产生了一定的正压 ,该正压随着灌水历时的延长而增大。影响地埋灌水器出口正压的主要因素是灌水器的额定流量和土壤初始含水量