Assessment of biomarkers influencing treatment success on small intestinal lymphoma in dogs

This study aimed to determine a reliable therapeutic biomarker for localized small intestinal lymphoma (SIL) in dogs based on clinical and histopathological features. We retrospectively investigated 84 dogs with localized SIL, including 36 dogs receiving surgery and 48 dogs receiving chemotherapy. The dogs receiving surgery were divided into two subgroups: 18 dogs (group 1) with overall survival (OS) <120 days (median OS) and 18 dogs (group 2) with OS ≥120 days. Correspondingly, the dogs receiving chemotherapy were divided into 24 dogs (group 3) with OS <98 days (median OS) and 24 dogs (group 4) with OS ≥98 days. Clinical, haematological, histopathological and immunohistochemical analyses were comparatively evaluated among the four subgroups. There was no significant difference in OS between the surgery and chemotherapy groups. In dogs receiving surgery, the rate of Ki67‐positive cells was significantly increased in group 1 compared to group 2 and showed no significant difference between groups 3 and 4. In dogs receiving chemotherapy, the rate of O6‐methylguanine‐DNA methyltransferase (MGMT) was significantly higher in group 3 than in group 4 and showed no significant difference between groups 1 and 2. Additionally, our data showed that OS in dogs with higher Ki67 expression might be significantly increased by chemotherapy than by surgery, that of those with higher MGMT expression might be significantly increased by surgery than by chemotherapy, and Ki67 and MGMT were independent of each other. Indices of Ki67 and MGMT are suggested therapeutic biomarkers to determine the optimal first‐line treatment for localized SIL in dogs.     

多拉菌素对猪寄生虫病的驱虫效果观察

比较不同来源的多拉菌素对猪消化道线虫和体表寄生虫的驱杀效果,为临床应用该药提供科学依据。将自然感染寄生虫的猪,随机分为高、中、低3个剂量的药物试验组和不给药物治疗对照组,健康无寄生虫感染的猪作为对照,根据试验前和试验后7、14、28、35 d猪寄生虫数量和临床变化判定疗效。结果显示,海正多拉与辉瑞通灭对猪的体表寄生虫及消化道线虫均有极好的驱杀作用,临床推荐剂量以中剂量组300μg/kg·BW肌肉注射为宜。     

结肠途径治疗机治疗慢性肾功能不全40例的疗效及护理

目的探讨结肠途径治疗机治疗慢性肾功能不全的临床疗效及护理。方法对慢性肾功能不全患者40例分成两组,分别进行结肠透析治疗和传统灌肠治疗及系统化护理,观察疗效。结果两组患者治疗后常见临床症状明显减轻或消失,治疗组明显优于对照组(P<0.05)。两组患者治疗后血尿素氮(BUN)、血肌酐(Scr)较治疗前明显降低,但治疗组比对照组改善明显,两组相比差异显著(P<0.05)。结论结肠途径治疗机治疗慢性肾功能不全,克服了传统灌肠方式只能达直肠段的缺点,能更充分彻底地清除体内的有毒物质,并促进肠黏膜吸收药物,达到治疗目的,其治疗效果优于传统的灌肠法;护理上应加强病情观察、心理护理及专科护理。     

Holothurian Fucosylated Chondroitin Sulfate

Fucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within disaccharide repeating units as regularly found in mammalian chondroitin sulfates. However, FucCS has also sulfated fucosyl branching units 3-O-linked to the acid residues. The sulfation patterns of these branches vary accordingly with holothurian species and account for different biological actions and responses. FucCSs may exhibit anticoagulant, antithrombotic, anti-inflammatory, anticancer, antiviral, and pro-angiogenic activities, besides its beneficial effects in hemodialysis, cellular growth modulation, fibrosis and hyperglycemia. Through an historical overview, this document covers most of the science regarding the holothurian FucCS. Both structural and medical properties of this unique GAG, investigated during the last 25 years, are systematically discussed herein.     

“微格教学法”运用于《基于疾病的中西诊疗思维综合训练》课程的实践与体会

目的 观察和探讨微格教学法在《基于疾病的中西诊疗思维综合训练》（以下简称《思训》）课程中的教学效果。方法 以全校自愿选修《思训》课程的208名学生为研究对象,采取问卷调查的方式,统计分析微格教学法的教学效果。结果 微格教学法在《思训》课程中得到了良好的应用,教学效果好,学生满意度高。结论 微格教学法将分散的知识集中化,让不同学科的知识更具连贯性,促进了学生主动思考和学习,提高了教学质量。