Lesions in the Larynx of Wistar RccHan: WIST Rats

Specific regions in the rat larynx exhibit cellular changes in response to inhaled xenobiotics. These regions include the base of the epiglottis, ventral pouch, and medial surfaces of the vocal processes of the arytenoid cartilages. 1 , 2 In order to collect information on the usefulness of trimming techniques, the influence of different vehicles, the impact of different application routes in toxicity studies, and differences between induced vs. spontaneous lesions, the data obtained from a large number of inhalation and non-inhalation studies performed in Wistar RCCHan(TM): Wist rats at Harlan Laboratories Ltd Switzerland, all evaluated or reviewed by the same pathologist, were compiled for a detailed review. The value of different trimming techniques was deemed to be greatest for transverse and sagittolongitudinal section techniques, as compared to horizontolongitudinally section techniques. The comparison of lesions encountered in control rats of inhalation studies treated with different vehicles did not reveal differences in the type, distribution pattern, incidence and/or severity of spontaneous lesions. The types of lesions were also independent of different application routes in non-inhalation studies compared to inhalation studies. The pattern of spontaneous lesions in the rodent larynx was determined by degenerative and inflammatory lesions starting most often in the submucosal glands by desiccated secretion followed by mineralization and local inflammation or were induced by impacted foreign bodies. Squamous metaplasia was recorded in the respiratory epithelium overlaying the ventral gland as a spontaneous lesion in male Wistar rats from inhalation studies with a maxim of 20.0% in an inhalation oncogenicity study. Induced metaplastic changes recorded in the larynx were reversible. Other induced lesions in inhalation studies consisted of submucosal edema, necrosis, inflammation and/or granuloma. Induced lesions in non-inhalation studies were found to be exclusively related to reflux laryngitis or food impaction. It is concluded, that in rodents induced lesions of the larynx differ in type, distribution pattern, severity and incidence from spontaneous lesions.     

诱致性节育：农村计生新政策

计划生育是我国的基本国策,是实现人口与经济资源可持续发展的必然保证。通过历史回顾和对比分析,我们认为,以高压政策为主的强制性节育,虽然达到了控制农村人口过快增长的目的,但严重地损害党群干群关系;而自发性节育政策,是以农民生育观念改善和较高的社会经济发展水平为前提,在当前中国一时难以产生预想效果,反而引起农民的误解,招致新一轮生育小高峰;所以本文提倡“奖励为主,惩罚为辅”的诱致性节育政策,通过构建具有实际益处的社会保障机制可以更好地逐步引导农民自觉节育,实现人口与经济社会协调发展。     

Identification of the spontaneous 7BS/7RL intergenomic translocation in one F1 multigeneric hybrid from the Triticeae tribe

The F1 AABBRH^ch hybrids studied here were produced by crosses between the Portuguese triticale cultivar 'Douro' (AABBRR) and the tritordeum line HT9 (AABBH^chH^ch). Fluorescent in situ hybridization performed with genomic DNA probes genomic in situ hybridization (GISH) from rye and Hordeum chilense allowed the unequivocal parental genomes discrimination in all hybrids. Among 55 plants, one presented a spontaneous wheat–rye translocation which was successfully detected after GISH. Recombinant chromosomes identification was made after reprobe with pTa71 and pSc119.2. Nine rDNA loci were detected by pTa71 and pSc119.2 identified the chromosome arms involved in the translocation, after comparing the observed hybridization patterns with those described by several authors. We identified the spontaneous wheat–rye translocation as being the 7BS/7RL. Many wheat–rye translocations have been found (e.g. 1BL.1RS and 1AL.1RS), but as far as we know, this is the first time that this translocation is reported. We considered it helpful for wheat breeding programmes as it could provide the transference of interesting agronomic characteristics from rye (e.g. leaf rust resistance) to wheat.     

弹簧垫圈断裂原因分析

通过宏观检验观察、化学成分分析、硬度测试、金相检验和断口分析等方法对弹簧垫圈的断裂原因进行分析。结果表明:该弹簧垫圈热处理时产生淬火裂纹,镀锌时氢原子在裂纹尖端偏聚,这两种因素的共同作用导致弹簧垫圈在装配预紧过程中发生脆性断裂。     

普洱茶提取物对自发性高血压大鼠降压研究

采用自发高血压大鼠（SHR）进行普洱茶提取物降压功效的研究。给予普洱茶提取物0.25、0.5、1.0、2.0g/kg灌胃4周,观察动物的血压、心率、体重变化。结果显示,以普洱茶提取物1.0g/kg和2.0g/kg灌胃4周,对动物的平均动脉压、收缩压和舒张压均有降低作用,与模型组间存在显著差异（P<0.01）。普洱茶提取物0.25g/kg和0.5g/kg组动物血压较模型组没有显著性改变。普洱茶提取物2.0g/kg可提高动物的心率,有抑制其体重增长的趋势;其他剂量组动物的心率及体重增长均无显著变化。研究表明,普洱茶提取物对自发高血压大鼠具有降压作用,且具有剂量依赖性。     

锁定钢板掌侧固定治疗桡骨远端不稳定骨折36例分析

目的 探讨桡骨远端不稳定骨折采用掌侧入路锁定钢板内固定的治疗效果.方法 2006-05-2010-10月我院收治36例桡骨远端不稳定骨折病人,AO分型为B及C型,应用桡骨远端斜T形锁定钢板,采取掌 侧入路对骨折行切开复位钢板内固定治疗并观察其临床应用效果.结果 36例患者均得到随访,随访12～18个月,平均15个月,根...     

PKP术治疗老年骨质疏松性胸腰椎 压缩性骨折的临床观察

〔摘要〕目的观察经皮椎体后凸成形术(percutaneous kyphoplasty , PKP)治疗老年骨质疏松性压缩性骨折的临 床疗效、方法对收治的符合纳入标准的38例老年骨质疏松性胸腰椎压缩性骨折患者应用PKP治疗并进行临床 疗效和影像学分析〔术后随访2个月、结果术后腰背部疼痛消失35例,疼痛明显减轻3例,无骨水泥渗漏〔术后 行影像学检查未见椎管内占位,后凸畸形明显改善、术后伤椎前柱平均高度明显提高(P<0.05 ) , Cobb角恢复至正 常水平,与术前比较差异有统计学意义(P<0.05 )、结论PKP术创伤小、安全、临床疗效好,能迅速缓解疼痛,有效恢 复伤椎高度,是治疗老年骨质疏松性胸腰椎压缩性骨折的理想治疗方法、     

Effect of intrafragmentary bupivacaine (haematoma block) on analgesic requirements in dogs undergoing fracture repair

Objective

To test the efficacy of intraoperative intrafragmentary administration of bupivacaine (haematoma block) in controlling postoperative pain in dogs undergoing osteosynthesis of long-bone isolated diaphyseal fractures.

Fixation of a complete scapular neck fracture in a foal using two 3.5 mm locking compression plates

This report describes the successful surgical repair of a transverse, displaced scapula fracture in a foal. A 3.5 mm locking compression plate (LCP) was used on either side of the spine of the scapula. The suprascapular nerve was apparent upon dissection as it passed directly over the fracture line and care was taken to leave it intact, although the fracture line itself caused some irritation. The foal recovered without long‐term nerve damage and is sound at 1.5 years post surgery.