REGIONAL BINDING INDEX OF THE RADIOLABELED SELECTIVE 5-HT2A ANTAGONIST 123I-5-I-R91150 IN THE NORMAL CANINE BRAIN IMAGED WITH SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY

The pattern of the specific 5-HT2A (5-hydroxytryptamine 2A receptor) antagonist 123I-5-I-R91150 was measured in 10 healthy dogs without neurologic and behavior abnormalities. Eight cortical regions (left and right fronto-, temporo-, parieto-, and occipitocortical area), one global subcortical region (including the thalamic system) were compared with a reference region lacking receptors; that is, the cerebellum. The 123I labeled radioligand was injected intravenously 100-200 minutes before acquisition. Both transmission and emission data were obtained with a triple head gamma camera equipped with high-resolution fanbeam collimators. The emission data were corrected for scatter and attenuation. To delineate different cerebral regions more accurately, the regions of interest (ROI) defined in a former study on brain perfusion measured with 99mTc-ethyl cysteinate dimer (ECD) in the same dogs were used. The co-registration of the 99mTc-ECD and the 123I-5-I-R91150, obtained from each dog, was realized with the help of corresponding transmission maps. By normalizing each regional cerebral activity to the activity observed in the cerebellum, the regional radioactivity (binding index) could be relatively quantified. Highest brain uptake was noted in the frontocortical brain areas (right: 1.85, left: 1.89), followed by the temporocortical region (right: 1.58, left: 1.56). Least uptake was noted in the more caudal and middle brain regions [occipito- (right: 1.46, left: 1.41), parietocortical (right: 1.30, left: 1.26), and striatal region (1.19)]. No gender nor age influence was noted in this series. The 123I labeled serotonin-2A receptor ligand seems to have similar cortical binding in the normal canine brain, as shown in humans and other animal species. A frontocortical to occipitocortical (rostrocaudal) binding index gradient was identified within the dog, which has not been seen in imaging studies from humans and other animal species. The significance of these results will need further investigation. This normative data can be used to compare regional brain uptake of the 123I-radioligand to dogs with behavioral disorders related to the serotonergic system, in future studies.     

井群元线自动控制系统的开发与应用

为了降低井灌区的运行管理费用，提高区域水资源的优化配置和井灌区运行的科学管理水平，利用计算机技术、单片机技术和通讯技术，结合地下水位预报模型，开发研制了井灌区井群无线自动控制系统。系统可根据区域水资源状况、机井工程布局及灌溉配水计划，设定系统运行参数，自动对井群系统运行进行控制、监视、计时计费和事故处理。     

层次前缀立方的有效计算

在联机分析处理系统中，基于维层次的上卷、下钻操作十分常见，但前缀立方却不直接支持维层次。文中扩展了前缀立方的组织结构，加入了层次数据立方的概念，即有层次维的数据立方，从而得到了层次前缀立方。它不仅保留了前缀立方在计算和组织结构上的优点，又能直接和充分支持维层次级的聚集查询。     

玉米改良单交技术的研究及应用

概述了我国玉米改良单交技术的原理、应用效果及改良单交种的选育方法、产量预测、生化研究等方面的研究成果，提出了该项技术的发展趋势。     

Superovulationsinduktion bei Merinolandschafen nach einmaliger oder multipler FSH-Applikation

Inhalt: Zyklussynchronisierte Merinolandschafe (n=79) wurden mit FSH-P in einer Gesamtdosis von 25 mg oder 17 mg superovuliert. Während die Versuchsgruppe 1 das Gonadotropin in Form einer mehrfachen Applikation in 12 stündigen Abständen erhielt (Gruppe 1/25 mg und 1/17 mg), wurde die Gesamtdosis bei Versuchsgruppe 2 36 Stunden vor Gestagenentzug (Gruppe 2/25 mg und 2/17 mg) und bei Versuchsgruppe 3 bei Gestagenentzug (Gruppe 3/25 mg und 3/17 mg) verabreicht. Die Embryonengewinnung wurde nach intrauteriner Eksamung der Tiere am 7.-11. Zyklustag durchgefülut.
Die Anzahl der Corpora lutea betrug in den einzelnen Stimulationsgruppen jeweils 11,8 ± 4,6; 9,2 ± 55; 8,4 ± 6,4; 7,2 ± 7,2; 8,8 ± 6,5 und 4,2 ± 2,9 C.l., wobei die Reaktion der Gruppe 3/17 mg signifikant niedriger als die der Gruppe 1/25 mg (p < 0,001), 1/17 mg (p < 0,01), 2/25 mg (p< 0,05) und 3/25 mg (p < 0,05) war. Die anderen Gruppe unterscheiden sich nicht signifikant.
Sowohl die Anzahl der erzielten Ovulationen als auch die Zahl der gewonnenen Eizellen/Embryonen lassen darauf schließen, daß die einmalige FSH-Applikation in höherer Dosierung, insbesondere bei Synchronisationsende, eine sinnvolle Alternative zu den gebräuchlichen Superovulationsmethoden beim Schaf darstellt.     

单缸柴油机进气模拟程序设计

本文建立了单缸柴油机进气管内气体流动的数学模型，并应用特征线数值解法原理设计了进气管内气体流动状况的计算机模拟程序，大大地方便了单缸柴油机的进气性能分析。     

The microflora and concentrations of volatile fatty acids in the rumen of cattle fed on single component rations

The composition of the rumen microflora and the volatile fatty acids were examined in cattle free-grazing on grass or stall-fed on hay, grass pellets, oats or dried beet pulp with molasses. Total and viable counts of anaerobic bacteria were highest on the grass feeding, but viable counts as a percentage of total counts were highest when oats or beet pulp with molasses were fed. Counts of cellulolytic bacteria were lowest on these latter 2 diets, and highest on grass or grass pellet diets. Studies of the anaerobic flora showed that the composition in animals fed on grass pellets resembled more that found in animals free-grazing on grass than in those fed on hay. Counts of aerotolerant bacteria were only a small percentage of the total count, but were highest on the hay diet. On this latter diet and on grass-feeding the streptococci (identified as Streptococcus bovis) were predominant, but contrary to expectation, streptococci were found only in small numbers on the oats diet, where coryneform rods were the major type present. Although a period of 4–6 weeks was allowed for the animals to adapt to the feeds, the 2 periods of feeding on oats and dried beet pulp with molasses markedly affected the composition of the rumen flora in the subsequent periods of feeding grass pellets and hay. Ruinen volatile fatty acid analysis showed a propionogenic effect of oats and the highest percentage of butyric acid when beet pulp with molasses was fed. The expected propionogenic effect of grass pellets was not observed.     

Fipronil modulation of GABAA receptor single-channel currents

Fipronil is the first phenylpyrazole insecticide introduced for pest control. Although fipronil is known to inhibit GABA receptors, the detailed mechanism of action remains to be seen. In order to elucidate the mechanism of fipronil interaction with the mammalian GABAA system, single-channel patch clamp experiments were performed using rat dorsal root ganglion neurons. The amplitude of main conductance state (27pS) current was not significantly altered by co-application of 10 microM fipronil and 10 microM GABA. The histograms of open time distribution were fitted to a sum of three exponential functions. After application of 10 microM fipronil, the proportion of the fastest component increased slightly and that of the slowest component decreased slightly. Thus, the mean open time was decreased from 11.4 ms to 7.8 ms by fipronil. The histograms of closed time distribution were fitted to a sum of four exponential functions. Fipronil 10 microM prolonged the slowest time constant resulting in a prolongation of the mean closed time from 29.7 ms to 52.8 ms. Thus, the frequency of channel openings was reduced. Thus, the fipronil suppression of GABA-induced whole-cell currents is caused in part by decreases in the channel open time and the frequency of channel openings.     

高精度保证下的浙江省森林植被生物量评估

为准确评估浙江省森林植被生物量,以2009年浙江省森林资源连续清查第一手野外调查数据为数据源,以样地为评估基本单元,采用单株生物量模型法(乔木,毛竹Phyllostachys edulis,杂竹,下木和灌木),单位面积生物量模型法(草本)和单位面积生物量法(矮化乔木林、灌木经济林),测算了样地水平的森林植被生物量.在此基础上,运用系统抽样统计方法,将样地水平微观数据转换到全省宏观尺度,评估了全省总体的森林植被生物量,提供了主要评估结果的估计精度和估计区间.结果显示:2009年,浙江省森林植被总生物量为37 010.732×104t.主要森林植被类型中,乔木林群落为29 096.269×104t,竹林群落3 762.964×104t,灌木林群落1 747.953×104t.在P＜0.05的可靠性保证下,森林植被总生物量估计精度为96.64％,估计区间为35 767.171×104～38 254.293×104t;乔木林群落9558％,估计区间为27 810.214×104～30 382324×1 04t;竹林群落89.13％,估计区间为3 353.930×104～4 171.998×104t;灌木林群落90.00％,估计区间为1 573.158×104～1 922.748×104t.可见,采用以上方法测算的浙江省各类森林植被生物量评估结果,均有很高的精度保证和较好可信度.     

菜心细胞质雄性不育系配合力分析

以菜心2个细胞质雄性不育系为母本,7个自交系为父本,配成10个杂交组合,对F1代单薹质量及其他生物学性状进行差异显著测验和品种比较,结果表明,组合间小区各性状存在极显著差异和显著差异。就单薹质量而言,组合269、271最大,其他生物学性状优良,是个极其优良的杂交组合。另外,266、267、268单薹质量也较大,主要生物学性状表现中等,也是较优组合。组合274、273单薹质量最轻,病株率高,其他生物学性状表现不好,应淘汰。