苦参注射液治疗乙型肝炎性肝硬化疗效及其作用机制研究

目的：观察苦参注射液对慢性乙型肝炎性肝硬化的临床效果及其作用机制.方法将58例慢性乙型肝炎性肝硬化患者随机分为观察组和对照组,在一般支持治疗的基础上,观察组加用苦参注射液,治疗8周后,比较两组肝功能、肝纤维化指标.结果观察组肝功能改善显著,肝纤维化减轻,与对照组比较差异均有统计学意义（P〈0.05）.结论在正常治疗基础上加用苦参注射液,有助于肝炎性肝硬化患者的肝功能恢复,有较好的临床效果.其作用机制可能是通过影响外周单核细胞IL-10表达、调节机体促炎抗炎平衡而实现的.     

土霉素固体脂质纳米粒在家兔体内的药代动力学研究

【目的】研究土霉素固体脂质纳米粒在家兔体内的药代动力学特征,以评价其应用效果。【方法】将10只家兔随机分为2组,分别按土霉素剂量20mg/kg腹腔注射土霉素固体脂质纳米粒和土霉素注射液,于设定的时间点采血,用HPLC法测定血浆药物质量浓度,并用DAS3.1.0药动学程序计算药代动力学参数。【结果】土霉素注射液与固体脂质纳米粒的达峰质量浓度(Cmax)分别为(3.676±0.376)和(3.699±0.562)mg/L;吸收平衰期(T1/2Ka)分别为(18.570±0.851)和(27.871±1.767)h;0-∞时段药时曲线下的面积(AUC(0-∞))分别为(83.955±3.720)和(170.150±10.403)mg/(L·h);0-∞时段的平均滞留时间(MRT(0-∞))分别为(36.848±0.268)和(44.672±0.392)h。【结论】土霉素制备成固体脂质纳米粒后,具有明显的缓释作用,血药质量浓度达峰值的时间推迟,同时药物在兔体内平均滞留时间明显长于土霉素注射液,生物利用度得以显著提高。     

褐点石斑鱼的核型研究

采用胸腔活体注射PHA和秋水仙素溶液,取头肾细胞,低渗处理,空气干燥法制片,对染色体进行G iem sa染色来研究褐点石斑鱼的核型。试验结果表明,禢点石斑鱼的核型为2n=48,2 sm 46 t,NF=50;其核型特点符合典型的高位类群鱼类核型特征。     

井窖式烟草移栽机设计与试验

针对井窖式烟草移栽人工栽植劳动强度较大、现有机械化装备作业效率和可靠性不高等问题,结合"井窖式烟草移栽技术"提出的农艺要求,设计一种用于井窖式烟草移栽的专用移栽机.在确定整机的结构和工作原理的基础上,对成穴移栽注水机构和栽植器进行设计,建立成穴移栽注水机构的运动学模型,以此建立其人机交互辅助界面,通过人机交互的方式获取...     

Content Determination of Ivermectin in the Ivermectin Microemulsion Injection

In order to establish the determination method of ivermectin (IVM) in the ivermectin microemulsion injection by high performance liquid chromatography (HPLC), Hypersil ODS2 colunm (5 μm,4.6 mm×250 mm) was used in this study. The mobile phase composed of methanol, acetonitrile and water (35:60:5,V/V/V) at a flow rate of 1 mL/min. The detection wave length was set at 244 nm and the column temperature was 30 ℃. The results showed that the HPLC system suitability of IVM was good. A good linear correlation of IVM was observed within the concentration range 80 to 320 μg/mL, and the average recovery rate was 101.90%±2.94% with RSD was 2.88%, the regression equation was Y=22 700X+2 510 (R²=0.9998). The RSD of IVM content in ivermectin microemulsion injection was 1.86%. The method was accurate and reliable,reproducible,easy to operate, which could be used in new type of ivermectin microemulsion injection. The method could be used as the basis of quality control and establishing a quality standard, and to provide basis for quality evaluation, also can provide reliable reference for safe veterinary clinical application in the future.     

Clinical Therapeutic Effect of Praziquantel Injection on Buffalo Schistosomiasis

To observe the clinical therapeutic effect of 30% praziquantel injection on buffalo schistosomiasis, the sick buffalos naturally infected with Schistosoma japonicum were selected by miracidium hatching method. In experimental clinical trials, sick buffalos were randomly divided into five groups, high-dose (20 mg/kg), middle-dose (10 mg/kg) and low-dose (5 mg/kg) praziquantel injection groups, praziquantel tablet group (30 mg/kg) and positive control group. After the treatment of 30 d, the negative conversion rate of miracidium were 100.0%, 100.0%, 77.8% and 85.7%, respectively, in praziquantel injection groups with the high, middle and low dose and oral medication group. In expanded clinical trials, the sick buffalos were randomly divided into two groups, praziquantel injection group (10 mg/kg, i.m.) and praziquantel tablet group (30 mg/kg). The results showed that, the negative conversion rate of miracidium were all 100% in the former 52 patients and the latter 6 patients after 30 d. The research confirmed that praziquantel injection was significantly effective in the treatment of buffalo schistosomiasis and convenient for administration. It was concluded that 30% praziquantel injection could replace the traditional oral praziquantel tablet for the treatment of buffalo schistosomiasis, and the recommended dose was 10 mg/kg.     

柴油发动机喷油泵喷油量自动检测装置实用化

原始的实验箱采用长方体结构,对燃气混合是不利的,因此首先考虑设计成型喷雾室,底部有突起,以规范气流的运动。实验台和喷油泵采用了安装定位工具将其固定。基于实际情况考虑选用了实用化设置图像采集卡,可以考虑其他几中系列产品。摄像机可以采用多种型号的CCD摄像头,像素要求35万。     

凌源市猪附红细胞体病诊断与防治研究

凌源市2002年3月首次发生以高热、贫血、黄疸、消瘦、流产为主要特征的猪附红细胞体病。血浆中、红细胞表面附有0.2-1.5μm多形态的生物体，姬姆萨染色呈淡紫红色。人工接种该生物体可使猪、兔发病，并能检出相同病原体。病猪是主要传染源，吸血昆虫、受污染的饲料、胎盘也传播。三氮咪为首选治疗药，配合性性血素疗效更好。     

二甲硝咪唑注射液的稳定性研究

从合成得到的水溶性二甲硝咪唑盐配方制备二甲硝咪唑注射液 ,对其进行光加速和热加速稳定性研究。证实本品对光不稳定、对热稳定 ,预测室温 (2 5℃ )避光保存有效期为 3.4 6年     

COMPUTER AIDED DESIGN OF THE CORE AND CAVITY OF PLASTIC INJECTION MOULD

This paper discusses the designing of the injection mould for producing the plastic case of TV set carried out in the type IBM PC/XT (or Great Wall 0520)micro-eomputer. The procedure consists of inputting the 2-D drawings of the TV set case with the aid of sub-drawing, coding and menu specifying; setting up the mathematic model according to the relationship between the plastic part and the mould; designing the core and caving of the mould and finally displaying and plotting the drawing of the mould. The connection between the Auto CAD software and the advanced language for orogramming and the data convertion is also discussed.