地胆头注射液的制备及其体外抑菌效果研究

分别用3种不同浓度的乙醇水溶液进行热回流浸提,制备地胆头原液.然后用醇溶液调pH值法除去鞣质以及乙醚脱脂、活性炭脱色等方法进行除杂脱色,制备地胆头有效部位注射液.对地胆头注射液进行了质量和安全性检查及体外药效试验.结果表明,制备的地胆头注射液对金黄色葡萄球菌、肺炎双球菌、大肠埃希氏杆菌和肠炎沙门氏菌均有明显的抑制作用,其中用65%乙醇提取制备的地胆头注射液效果最好,3种注射液都具有很好的澄明度和安全性.     

Effect of Shenfu injection on hemodynamics of hypovolemic shock and oxygen delivery

AIM: To evaluate the effect of Shenfu injection on hemodynamics of hypovolemic shock patients and oxygen delivery by transesophageal Doppler echocardiography (Hemosonic 100 TM). METHODS: The transesophageal probe was placed in 32 patients with hypovolemic shock. 50 mL Shenfu injection were intravenously administered within 5 min. The parameters, including ABF, SVa, Acc, LVETi and TSVRa, were recorded at interval of 5, 10, 20, 30, 60 and 120 min. Meanwhile, MAP was measured at the same interval. Arterial and venous blood gases were taken at the beginning and 30, 60 and 120 min of the trial. DO2, VO2 and ERO2 were calculated. RESULTS: Acc, SVa, ABF increased while TSVRa decreased at 10 min after administration of Shenfu injection (P<0.01). DO2 and VO2 increased (P<0.01) and ERO2 decreased (P<0.05). CONCLUSION: Shenfu injection has a beneficial effect on hypovolemic shock by increasing cardiac output and improving oxygen delivery.     

喷射系统工作对柴油机动力性的影响

本文从理论角度分析研究了柴油机喷射系统工作时，各种现象对柴油机动力性的影响，为实际使用提供一定的理论依据。     

林可霉素注射液非法添加盐酸左旋咪唑的HPLC检测方法研究

建立了兽用林可霉素注射液中非法添加盐酸左旋咪唑的高效液相色谱检测方法。采用Waters Atlantis? T3 C18(4.6×250mm, 5μm)色谱柱分离,以磷酸二氢钠溶液-甲醇(70:30)作为流动相进行等度洗脱（流速1.00mL/min）,用二极管阵列检测器在230nm波长处进行测定。考察了此色谱条件下方法的专属性、线性、回收率、精密度、检测限和耐用性。结果表明,盐酸左旋咪唑在进样浓度为0.02mg/mL～0.4mg/mL时呈良好的线性关系,R2=0.9999;重复性试验RSD为0.6%;平均回收率为99.7%;检测限为 0.0002mg/mL,定量限为0.0016mg/mL。该法准确、简便、可行,适用于林可霉素注射液中盐酸左旋咪唑的检测。     

汽车内饰件注塑成型工艺参数的分析与优化

以汽车内饰件为研究对象,设计合适的浇注系统和冷却系统,优化模具温度、熔胶温度、注塑时间、注射压力、保压压力、保压时间等工艺参数.利用Moldflow和正交试验法,通过模拟实验得出不同工艺参数组合下的翘曲变形量.通过均值分析和极差分析研究各个工艺参数对翘曲变形量的影响,得到一组较为理想的工艺参数组合,使得翘曲变形量得到优...     

喷油泵回油压力对油耗测试精度的影响及解决方法

为提高发动机的油耗测试精度，对影响油耗测试精度的主要原因及其解决方法进行了分析研究和试验。试验表明：柱塞式喷油泵的回油压力是影响测试精度的主要原因，用软件消除回油压力信号和用消波器消除回油压力波，是消除回油压力影响、提高油耗测试精度最简便可靠的方法。     

Evaluation of adverse reactions in dogs following intravenous mesenchymal stem cell transplantation

Background

Recent studies have assessed the therapeutic potential and drawbacks of mesenchymal stem cells (MSCs). The adverse reactions of intravenous transplantation of bone marrow (BM)-derived MSCs were examined at varying doses and frequencies of administration.Nine healthy beagle dogs were purchased from a commercial laboratory. The dogs were distributed equally (n = 3 per group) and randomly into three groups. All dogs received allogeneic BM-derived MSCs: 2 × 10⁶ once (group A), 2 × 10⁷ once (group B), and 2 × 10⁶ for three consecutive days (group C). Various laboratory examinations, multi-detector computed tomography features and histopathology were evaluated to clarify the clinical and diagnostic features of adverse reactions of MSCs administration, prior to receiving MSCs (pre procedure) and on days 1, 3, and 7 post transplantation.

Results

Only one dog had clinical signs during and after MSCs transplantation. Dogs receiving 2 × 10⁶ MSCs showed increased numbers of lymphocytes but the total white blood cell counts were not elevated (P < 0.01). Multi-detector computed tomography (MDCT) revealed pulmonary parenchymal changes in one dog and histopathologic examination revealed pulmonary parenchymal edema and hemorrhage in four dogs. The presence of pulmonary thromboembolism was not detected in either examination.

Conclusions

We considered the presence of pulmonary edema and hemorrhage as possible adverse reactions after intravenous MSCs transplantation; however these results should be cautiously interpreted.     

秸秆“富集深还”新模式及工程技术

针对长期浅耕造成的土壤亚表层缺乏有机质和过于紧实以及目前秸秆还田成本高或效果差的实际问题,提出了一种简单而有效的快速松土培肥的秸秆还田新模式及相应机具创新和田间工程技术。该技术模式是基于优先快速培肥土壤亚表层的新理念,在条带轮耕深松土壤的同时,将秸秆富集深埋于指定条带的土壤亚表层。将这种秸秆还田新模式称为秸秆富集深埋还田(简称"富集深还"),其主要工程技术是发明研制了秸秆深还筒式犁新机具,通过机械化手段将秸秆富集、粉碎、埋入土壤。具体步骤包括:(1)用指盘式搂草机将玉米秸秆按4∶1~8∶1富集归行;(2)用秸秆还田筒式犁一体机将秸秆粉碎、风力注入指定条带土壤20~40 cm;(3)用免耕播种机在非埋秸秆条带正常免耕播种,实现种还分离,即种植条带(窄行)与埋秸秆条带(宽行)分离。该模式具有秸秆翻压还田与覆盖还田的优点,而克服二者各自的缺点,是秸秆还田与条带少免耕的完美结合,能够实现玉米秸秆连年、机械化全量还田,且不打乱土层顺序、不影响第二年种植。秸秆富集深埋还田,理念新颖,技术可行,对土壤尤其是亚表层有很好的培肥效果。有助于彻底解决秸秆还田成本高或效果差的瓶颈问题,为旱田秸秆田间处理与深厚肥沃耕层构建提供切实可行的机械化工程手段。     

康福多防治杨树天牛成虫试验初报

２０％ 康福多浓可溶剂具有很强的内吸输导作用,采用树干打孔注药法防治杨树天牛成虫,具有高效、长效的特点。施药３个月后用鲜枝叶饲养天牛成虫,死亡率仍达７０～８０％ 。康福多是注射药剂中持效期较长的品种。     

两种新型制剂对人工诱发鸡白痢的疗效观察

为了评价头孢噻呋不同剂型、不同用法对革兰氏阴性菌所致鸡病的临床疗效。采用3日龄雏鸡人工诱发鸡白痢,接种后5小时分别对6组试验鸡给以不同剂量头孢噻呋混悬液(注射)和头孢噻呋钠冻干粉(灌服),每天一次,连用三天,同时对另3组试验鸡用硫酸粘杆菌素、氟苯尼考、氨苄西林混悬注射液作药物治疗对照。用药后15天试验结果表明:头孢噻呋治疗组的平均死亡率为8 3%,对照药物治疗组的死亡率分别为26 6%(氨苄西林混悬注射液)、10 0%(硫酸粘杆菌素)、23 3%(氟苯尼考)。头孢噻呋组的平均治愈率为87 75%,对照药物治疗组的治愈率分别为70%(氨苄西林混悬注射液)、76 6%(硫酸粘杆菌素)、63 3%(氟苯尼考)。头孢噻呋的治疗效果在死亡率、有效率和治愈率的指标比较上,均显著高于对照药物;头孢噻呋混悬液和冻干粉在同剂量水平比较上,疗效无统计学差异;两剂型高、中剂量组的疗效均高于低剂量组。