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排序方式: 共有413条查询结果,搜索用时 31 毫秒
51.
Kanichi KUSANO Yuhiro ISHIKAWA Kazuhiro SEKI Ryo KUSUNOSE 《Journal of Equine Science》2008,19(2):25-29
Inflammatory airway disease (IAD) is a common cause of poor performance, interruption of
training and premature retirement in racehorses. It is also reported that up to 80% of
horses are affected at some point in the first years of training in UK and Australia.
However, no studies with regard to the information on occurrence of IAD in Japanese
Thoroughbred racehorses have been reported. To investigate the occurrence and the
characteristics of IAD, epidemic research including endoscopic examination of the airway
tract and trachea wash was conducted for Thoroughbred racehorses presenting coughs or poor
performance which airway tract disease was suspected stalled in training facility managed
by Japan Racing Association. Fifty-six out of 76 Thoroughbred racehorses (73.7%)
presenting coughing or poor performance were diagnosed as IAD. Mean incidence rate of IAD
was 0.3% and it has been confirmed that constant number of IAD exists in Japan. Up to
35.7% of IAD horses showed upper airway abnormalities in some extent. There was a trend
for IAD horses to use wood shavings for bedding and fed hay from the ground compared with
the control group. Therefore, improvement of stabling environment may aid in preventing
IAD. This study demonstrated that Japanese Thoroughbred racehorses are affected by IAD
likewise other countries as well as demonstrated the characteristics of IAD which may
contribute to the clarification of the pathogenesis of IAD. 相似文献
52.
Cytology of tracheal aspirates, tracheal endoscopic and blood tests were carried out to
86 Thoroughbred racehorses presenting coughs or poor performance which were suspected to
have lower respiratory tract disease (LRTD) to assess the conditions of the disorders.
Racehorses were classified into coughing (66 horses) and non-coughing (20 horses) groups
based on clinical symptoms. Nine Thoroughbred racehorses without respiratory abnormality
were used as controls. Assessment of grades of airway mucus, cytology of tracheal
aspirates and serum amyloid A (SAA), fibrinogen (Fbg) and pulmonary surfactant protein D
(SP-D) measurements were performed. Relationships between age, gender and racing careers
were also investigated to understand the characteristics of LRTD in racehorses. Mean age
was significantly higher in non-coughing group compared to coughing group. Existence of
racing career and number of starts were significantly greater in non-coughing group
compared to coughing group. On the other hand, grades of airway mucus were significantly
higher in coughing group compared to control group. Percentages of neutrophils in tracheal
aspirates were significantly higher in coughing group compared to non-coughing and control
groups. SAA, Fbg and SP-D were higher in coughing group compared to non-coughing and
control groups indicating that condition of coughing group is in the acute phase. Positive
rate of inflammatory airway disease was significantly higher in coughing and non-coughing
groups compared to control group. It was concluded that carrying out comprehensive
evaluation including investigation on SAA, Fbg and SP-D analysis with airway assessment to
Thoroughbred racehorses which were suspected to have LRTD are useful procedure to
understand the pathological condition which aid to initiate appropriate treatment,
prognosis judgment or to advise trainers to consider altering training regimen. 相似文献
53.
54.
Jiao Song Xin Lei Jingxian Luo Nadia Everaert Guiping Zhao Jie Wen Ye Yang 《Journal of animal physiology and animal nutrition》2019,103(4):1030-1038
This study was to investigate the effects of Epigallocatechin‐3‐gallate (EGCG) on intestinal morphology, antioxidant capacity and anti‐inflammatory response in heat‐stressed broiler. A total of 192 2‐week‐old Arbour Acres broilers chickens were divided into four groups with six replicates per group and eight chickens per replicate: one thermoneutral control group (28°C, group TN), which was fed the basal diet; and three cyclic high‐temperature groups (35°C from 7:00 to 19:00 hr; 28°C from 19:00 hr to 7:00 hr, heat stress group), which were fed the basal diet supplementation with EGCG 0 mg/kg (group HS0), 300 mg/kg (group HS300) and 600 mg/kg (group HS600). The gut morphology and intestinal mucosal oxidative stress indicators, as well as intestinal barrier‐related gene expression, were analysed. The results showed that compared with group TN, heat stress reduced the villus height (VH), activities of glutathione peroxidase (GSH‐Px), superoxide dismutase (SOD)and catalase (CAT), increased the crypt depth (CD) and malondialdehyde (MDA)content at 21, 28 and 35 days (p < 0.05). After the heat‐stressed broilers were supplemented with EGCG, VH, VH/CD (V/C), and the activities of GSH‐Px, SOD and CAT were increased, and CD and MDA content were reduced compared with those in group HS0 without EGCG supplementation at 21, 28 and 35 days (p < 0.05). The EGCG supplementation promoted the gene expression of nuclear factor‐erythroid 2‐related factor 2 (Nrf2), Claudin‐1, Mucin 2 (Muc2) and alleviated the nuclear factor‐kappa B (NF‐κB) and lipopolysaccharide‐induced tumour necrosis factor (LITAF) gene expression compared with group HS0 (p < 0.05). Moreover, intestinal morphology was strongly correlated with antioxidant ability and inflammatory response. In conclusion, EGCG alleviated the gut oxidative injury of heat‐stressed broilers by enhancing antioxidant capacity and inhibiting inflammatory response. 相似文献
55.
56.
探讨黄芩汤预防及治疗感染大肠杆菌K88小鼠的作用与机理。通过观察统计小鼠的死亡率,采用血常规检测小鼠血液中白细胞、红细胞及血小板的变化以及采用显色基质鲎试剂法和ELISA法检测小鼠血清中的IL-1β、IL-6、TNF-α和LPS的变化。结果显示,预防试验中黄芩汤组小鼠死亡率为25%,治疗试验中黄芩汤组死亡率为40%,均极显著地低于对照组(P<0.01);黄芩汤组中小鼠血液中各项白细胞指标均极显著地低于对照组(P<0.01),各项红细胞指标均极显著地高于对照组(P<0.01),LPS及TNF-α、IL-1β、IL-6的含量均极显著地低于对照组(P<0.01)。结果表明:黄芩汤对感染大肠杆菌K88小鼠有极显著的预防与治疗作用。 相似文献
57.
58.
JRS Dandrieux LM Martinez Lopez N Prakash CS Mansfield 《Australian veterinary journal》2019,97(9):301-307
Chronic enteropathy (CE) in dogs is common worldwide, but little data is available from Australia. The aim of this study was to describe treatment response and long‐term outcome in a cohort of dogs with CE. Dogs were prospectively enrolled at Murdoch University and the University of Melbourne. After diagnostic investigation to rule out diseases other than CE, dogs underwent sequential therapeutic trials until achieving a clinical response (diet then antibiotics, and finally immunosuppressants). Success was defined as 75% reduction of clinical severity for a minimum of five weeks. A total of 21 dogs were enrolled, and 19 completed the study. One dog was euthanised for lack of response to treatment and one excluded for lack of owner compliance. Most dogs responded to diet (n = 10), followed by antibiotics (n = 7) and immunosuppressants (n = 2). Long‐term remission (median 21.1 months, [3.0‐44.7]) was achieved in eight out of ten dietary responders without additional treatment. In contrast, only two dogs with antibiotic response remained in long‐term remission, of which one needed on‐going antibiotic treatment. Longer term remission was achieved in the two dogs treated with immunosuppressants with on‐going low dose therapy. This study concludes that most dogs referred for CE in Australia respond to dietary treatment (even after previous dietary interventions), and remission is long‐term compared to dogs treated with an antibiotic. Furthermore, the need for long‐term antibiotics in some dogs to maintain response may lead to antibiotic resistance. This study supports adequate dietary trials for CE in dogs, and a need for alternative second‐line treatments. 相似文献
59.
60.
The effect of intravenous fresh frozen plasma administration on fibrinogen and albumin concentrations in sick neonatal foals 下载免费PDF全文
A. R. Hollis P. A. Wilkins B. Tennent‐Brown J. E. Palmer R. C. Boston 《Equine Veterinary Education》2016,28(3):145-149
This study investigated the immediate (6 h or less) effects of fibrinogen and albumin contained in transfused equine origin fresh frozen plasma on those proteins when measured in sick neonatal foals. Fibrinogen and albumin concentrations were measured in the administered plasma and in 31 sick foals at admission to a referral neonatal intensive care unit. Additional samples were obtained from the foals at 2 and 6 h following transfusion. No changes in albumin concentration were recognised. The main determinant of fibrinogen concentration following transfusion was the concentration of fibrinogen in the foal at admission. Importantly, intravenous transfusion of equine fresh frozen plasma did not result in immediate (6 h or less) increases or decreases in the fibrinogen concentration in the recipient foals. Fibrinogen from the donor contained within transfused plasma will not directly affect fibrinogen concentrations measured at later times. 相似文献