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Pablo Pi?eyro Miranda D. Vieson José A. Ramos-Vara Martha Moon-Larson Geoffrey Saunders 《Journal of veterinary science (Suw?n-si, Korea)》2014,15(3):449-453
This report describes the gross, histological, and immunohistochemical features of medullary thyroid carcinoma (MTC) with pulmonary metastases in a young dog. Sheets of pleomorphic cells supported by fibrous stroma characterized the primary mass, while metastatic nodules had a neuroendocrine pattern. Despite differing histologic features, all masses showed marked immunoreactivity against calcitonin and multiple neuroendocrine markers consistent with MTC. Although MTC is a well-recognized entity, it may be difficult to distinguish this mass from other thyroid neoplasms, necessitating immunohistochemical characterization. 相似文献