ZrO_2对Al_2O_3基泡沫陶瓷过滤器的性能影响

以Al2O3为主要成分的料浆中加入ZrO2,采用有机泡沫浸渍法,用1560℃烧结制备Al2O3基泡沫陶瓷过滤器,并测定不同ZrO2含量过滤器样品的抗压强度、热震次数并观察其显微结构,实验结果表明:Al2O3基泡沫陶瓷的抗压强度、抗热震性能随ZrO2加入量的增加先增加,而后略有下降。在ZrO2加入量为20%(重量)时制品的抗压强度及抗热震性能最佳,其最高抗压强度达2.31 MPa,1100℃热震循环次数为16次。     

离心泵叶轮三维造型

离心泵叶轮是离心泵的最主要的部件,它的设计与造型至关重要。通过利用读入数据和、pro/e,对离心泵叶轮进行三维造型,为下一步的分析计算打下基础。     

带分流叶片的离心泵叶轮三维贴体网格生成

采用泊松方程进行带分流叶片的离心泵叶轮内三维贴体网格的自动生成 ,并通过源项控制来满足网格的正交性及调整网格疏密。计算时根据边界处网格线正交的控制角和控制距离的几何约束确定边界条件 ,利用分块粘接技术生成了带分流叶片离心泵叶轮内的三维分块结构化贴体网格 ,从而提高了流场流动分析中前处理环节的效率和精度 ,能使在湍流计算中广泛应用的壁面函数法的条件容易满足 ,并能使普遍采用的压力第二边界条件直接用于计算中 ,还能满足差分要求 ,减小离散误差。     

低比转数离心泵叶轮出口紊流流动结构分析

在叶轮内三维紊流流动数值计算的基础上，从介质能量的观点，分析了不同工况下低比转数离心泵叶轮出口处的紊流流动结构。数值计算采用SIMPLEC算法，在贴体坐标系下求解Navier—Stokes方程，紊流模型采用标准的κ—ε模型。计算结果表明，在叶轮的出口附近靠近吸力面一侧存在一个低能区，而压力面一侧能量相对较高。这与有关文献中所指出的离心风机的“射流—尾流”结构相对应。当偏离设计工况时，该低能区的范围和强度略有增加，相对应的叶轮效率也降低。计算结果与水泵在这些工况下的效率实验结果相一致，说明低能区的存在是影响低比转数离心泵效率的重要因素。     

用转轮内三元流动计算对泵叶轮进行改型设计

在有厚翼栅奇点解法的基础上，利用一种考虑叶片厚度影响的叶片式水力机械转轮内准三元流动新的分析方法、准确计算了泵叶轮叶片表面上的速度与压力变化分布规律，获得了许多水力性能评估参数；通过评价这些参数，对叶片型线进行了修改，获得了比较满意的结果。为叶轮的改型设计提供了一条较有价值的新途径。     

高速柴油机曲轴扭/弯/纵三维振动的试验研究

利用开发的轴系扭 /弯 /纵三维振动测试装置 ,对典型的直列 6缸车用柴油机进行了轴系扭 /弯 /纵三维振动的测试研究。通过对轴系振动的测试结果进行幅频特性分析以及相干函数分析 ,从试验研究的角度分析了轴系扭 /弯 /纵三维振动的相互影响的特点。同时 ,研究了轴系的三维振动与机体裙部振动的关系。     

云龙河拱坝施工过程的三维有限元

采用三维弹塑性非线性有限元法，对云龙河拱坝施工过程的实际浇筑、封拱和水库蓄水过程的坝体应力及变形进行了仿真分析，同时分析了施工过程的坝肩层间错层带的变形。计算结果表明施工过程的坝体变形较小，坝体有限元等效应力满足规范要求，坝肩层间错层带错动变形很小，说明大坝结构设计合理，坝肩无错动危险。计算成果为工程项目的实施提供了技术依据，同时对类似工程分析具有借鉴作用。     

惯性沉降分离室内三维定常气流流动数值计算

为了解气流在4ZTL-1800型割前摘脱稻（麦）联合收获机惯性沉降分离室内的运动规律，从流体力学和湍流理论出发，建立了气体运动微分方程式及k-ε湍流模型，并利用Fluent软件对惯性沉降分离室内三维定常气流进行了数值计算，得到了气体在惯性沉降分离室内的流动特征。根据其特征对分离室结构进行了改进设计，数值计算结果表明改进后惯性沉降分离室内的气流流场得到了改善。     

Mechanism of Fuzilizhong decoction alleviating inflammatory damage of rats with non-alcoholic fatty liver disease

AIM To observe the effect of Fuzilizhong decoction on the inflammatory damage of non-alcoholic fatty liver disease （NAFLD） rats and to explore its mechanism. METHODS SPF male SD rats were randomly divided into 6 groups： control group, model group, high dose （20 mg·kg^-1·d^-1）, middle dose （10 mg·kg^-1·d^-1）, low dose （5 mg·kg^-1·d^-1） Fuzilizhong decoction group and Yishanfu （30 mg·kg^-1·d^-1）group, 8 rats in each group. A NAFLD rat modelwas established by intragastric administration of fat emulsion for 4 weeks. Then the drug was given for 4 weeks in each treatment group. HE staining was performed to observe the histopathological changes of the rat liver.The serum levels of interleukin-2（IL-2）, IL-6 and tumor necrosis factor-α（TNF-α） were measured by ELISA. The expression of toll like receptor 4（TLR4） and NF-κB p65 in liver tissues at mRNA and protein levels was determined by RT-qPCR and Western bolt,respectively. RESULTS Compared with control group, the inflammatory damage of liver tissue was more serious, the serum levels of IL-2, IL-6 and TNF-α, the mRNA expression TLR4 and NF-κB p65 in liver tissues were significantly increased in model group（P<0.05）. However, compared with model group, the liver pathological changes in each treatment group were significantly relieved, the serum levels of IL-2, IL-6 and TNF-α, the mRNA expression of TLR4 and NF-κB p65 in liver tissues were significantly reduced（P<0.05）.In addition, the changes of TLR4 and p-NF-κB p65 protein levels in liver tissue were consistent with the changes of TLR4 and NF-κB p65 mRNA. CONCLUSION Fuzilizhong decoction attenuates the inflammatory damages of NAFLD in rats by inhibiting TLR4/NF-κB p65 signaling pathway.     

p300/p53/Smad3 pathway involved in aging-related atrial fibrosis in human atrial fibroblasts

AIM To investigate the role of p300 in aging-related atrial fibrosis in human atrial fibroblasts （HAFs） and its potential mechanism. METHODS HAFs were obtained from human left atrial tissue, and the senescence model was established by cell passage. Senescence-associated β-galactosidase （SA-β-Gal） staining was used to detect the cell senescence, and Western blot was used to determine the protein levels of p300, p53, Smad3 and other senescence and fibrosis associated proteins in HAFs. RESULTS Compared to passage 3 HAFs, the proportion of senescent cells, and the protein levels of p300, p53, p-Smad3 and other senescence and fibrosis associated proteins were increased in HAFs at passage 7 and 11 （P<0.05）. After treated with curcumin （a p300 inhibitor） or transfection with p300 small-hairpin （sh） RNA plasmid, the protein levels of p300, and the senescence and fibrosis associated proteins were decreased in HAFs at passage 7（P<0.05）. Up-regulation of p300 by transfection with p300 over-expression plasmid increased the protein levels of p53, Smad3 and MMP-2 in HAFs at passage 3 （P<0.05）. CONCLUSION p300/p53/Smad3 signaling pathway plays an important role in aging-related atrial fibrosis in HAFs.