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AIM:To explore the relationship between change of serum melatonin (MT) and pathogenesis of hepatic encephalopathy (HE). METHODS: Changes of MT level in sera of cirrhosic patients with HE and without HE were determined by ELISA, normal serum served as control. The change of serum MT level in exacerbation and remission in HE was also determined.RESULTS:MT level in patients with HE was higher than that withour HE (P<0.01). MT levels of both groups were higher than that of normal group (P<0.01). They were (308.53±59.07) ng/L, (139.85±34.59)ng/L,(77.73±28.41)ng/L, respectively. Serum MT level in exacerbation was higher than that in remission (P<0.01), they were (301.52±66.42)ng/L and (147.81±23.31) ng/L, respectively. CONCLUSION: The elevation of MT content in sera may be closely related to the onset of hepatic coma. 相似文献
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There are two type of cardiac calcium channel current, both are inward current: (1) L-type Ca2+channel current (Ica-L), plays a major role in determining myocyte action potential plateau characteristics as well as initiating the myocyte excitation-contraction coupling; (2) T-type Ca2+ channel current (Ica-T), probably plays an important role in pacemaker activity. The alterations of L-type calcium channel abundance and function in cardiac hypertrophy and heart failure are determined by the the species difference, especially by the stage of the disease process and the degree of the disease. Both abundance and function of L-type calcium channel decrease in severe hypertrophy and heart failure. 相似文献
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针对岩质边坡的稳定性评价问题,应用粗糙集理论对既有岩质边坡的失稳实例进行分析,采用遗传算法进行约简,抽取评价知识,建立了规则库。采用不精确推理和默认推理方法开发了岩质边坡稳定性评价专家系统,提出了待评对象与规则不完全匹配情况下的近似推理方法,结合工程实例对该系统进行了测试和验证,并与模糊回归方法进行的比较。 相似文献
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ZHANG Fei-fei Zhao Shi-xia HAO Qing-qing Li Rong LI Ying-xiao Dang yi QI Xiao-yong 《园艺学报》2020,36(3):547-551
AIM: To investigate the effects of cardiac contractility modulation (CCM) on ventricular electrical remodeling in a rabbit model of chronic heart failure. METHODS: The rabbits were divided into sham group, heart failure(HF) group and HF+ CCM group. The rabbit model of chronic heart failure was established by ligating the ascending aortic root. Then electrical stimulations during the absolute refractory period were delivered lasting 6 h everyday for 4 weeks in rabbits of HF+ CCM group. The QTc and ventricular effective refrective period (VERP) were recorded. The protein and mRNA levels of Kv1.4, Kv4.3 and connexin 43 (Cx43) were determined by Western blot and RT-qPCR. RESULTS: Compared with sham group, QTc were significantly prolonged in HF rabbits at week 12 (P <0.05). CCM therapy shortened QTc of rabbits with heart failure at week 16 (P <0.05). Compared with sham group, VERP significantly increased in HF group and HF+ CCM group, while CCM therapy shortened VERP of rabbits with heart failure at week 16 (P <0.05). Compared with sham group, the mRNA and protein levels of Kv1.4, Kv4.3 and Cx43 were decreased in HF group and HF+ CCM group (P <0.05). However, CCM therapy restored the mRNA and protein levels of Kv1.4, Kv4.3 and Cx43 of rabbits with heart failure (P <0.05). CONCLUSION: CCM suppresses ventricular electrical remodeling in heart failure and the underlying mechanism may be associated with increasing Kv1.4, Kv4.3 and Cx43 expression. 相似文献
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目的 总结“阳黄-阴阳黄-阴黄”辨证模式治疗肝瘟病用药规律。方法 基于“中医临床科研信息一体化技术平台”,制定纳入和排除标准,规则化处理后建立肝瘟病用药数据库,采用频数分析、复杂网络分析、点式互信息等分析方法进行数据挖掘。结果 肝瘟病总体用药频次依次为:茵陈(1 368),赤芍(1 309),丹参(1 250),甘草(1 086),白术(1 038)等;其中阳黄证以茵陈(1 062),赤芍(1 016),丹参(970),甘草(823),石菖蒲(796),白术(760)等为主;阴阳黄证以茵陈(285),赤芍(272),白术(268),丹参(260),薏苡仁(245)等为主。核心用药中阳黄证为茵陈、赤芍、丹参;阴阳黄证为白术、茵陈、薏苡仁、附子、丹参、赤芍。阳黄、阴阳黄阶段即开始配伍白术、附子等温阳药物。结论 肝瘟病用药总以清热利湿解毒、凉血活血化瘀、益气健脾为主。阳黄证以清热利湿解毒、凉血化瘀为主,阴阳黄证以温阳健脾、活血退黄为主,早期应用温法干预治疗可延缓阴黄化进程。 相似文献
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目的 探讨不同剂量大黄附子细辛汤对慢性肾衰竭脾肾阳虚证患者炎症因子及临床疗效的观察。方法 120例确诊的慢性肾功能衰竭脾肾阳虚证患者随机分为治疗组和对照组各60例,两组在常规治疗基础之上,对照组给予小剂量大黄附子细辛汤,治疗组给予大剂量大黄附子细辛汤,观察两组患者治疗前后尿素氮(BUN)、血肌酐(Scr)、血清胱抑素C(CysC)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-a (TNF-a)水平、药物不良反应及临床疗效。结果 两组患者血清BUN、Scr、CysC、IL-6、TNF-a较治疗前均明显降低,治疗组下降幅度更为显著(P<0.05),治疗组治疗后中医证候积分及综合疗效均优于对照组(P<0.05),治疗后2组安全性比较无显著差异(P>0.05)。结论 大剂量大黄附子细辛汤对慢性肾功能衰竭脾肾阳虚证患者中有助于改善肾功能,降低炎症因子水平,可能与降低血清炎性因子IL-6、TNF-a值,发挥抗炎及促进肾代谢作用有关。 相似文献